UniProt:P80217 IFI35

chain
  • initiator methionine:
  • chain:2-286
checksum 3FCAB26E97317508
comment
  • FUNCTION Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465).SUBUNIT Homodimer (PubMed:8288566, PubMed:10950963). Also interacts with BATF (PubMed:8954125). Interacts with TRIM21 (PubMed:26342464). Interacts with NMI; the interaction is direct and is facilitated by TRIM21 (PubMed:10779520, PubMed:10950963, PubMed:26342464).INTERACTION Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN-alpha (PubMed:8288566, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465).ALTERNATIVE PRODUCTS Expressed in a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.INDUCTION Up-regulated by interferons IFN-alpha and IFN-gamma.DOMAIN The NID domain 1 is involved in the negative regulation of p65/RELA transcription and the negative regulation of NF-kappa-B pathway activation.PTM Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI.MISCELLANEOUS Due to a polymorphism at the 3'-splice acceptor site of intron 4.SIMILARITY Belongs to the NMI family.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.
crossReference
databaseName UniProt
dbId 57353
description
  • recommendedName: fullName evidence="15"Interferon-induced 35 kDa protein shortName evidence="13 15"IFP 35 shortName evidence="12 14"Ifi-35
displayName UniProt:P80217 IFI35
geneName
  • IFI35
  • IFP35
identifier P80217
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Immunity
  • Innate immunity
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Secreted
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • IFI35
otherIdentifier
  • 11719491_a_at
  • 11719492_s_at
  • 16834545
  • 209417_PM_s_at
  • 209417_s_at
  • 3430
  • 3722339
  • 3722343
  • 3722345
  • 3722346
  • 3722347
  • 3722349
  • 3722350
  • 3722351
  • 3722352
  • 464_s_at
  • 626_s_at
  • 74908_at
  • 8007446
  • A_23_P152782
  • GE59382
  • GO:0002281
  • GO:0002376
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0005737
  • GO:0005829
  • GO:0006954
  • GO:0008285
  • GO:0016020
  • GO:0023052
  • GO:0034145
  • GO:0042802
  • GO:0043226
  • GO:0045087
  • GO:0045089
  • GO:0050729
  • GO:0098542
  • GO:1901223
  • GO:1901224
  • HMNXSV003022781
  • ILMN_1745374
  • L78833_cds4_at
  • TC17000545.hg
  • U72882_s_at
  • g12655016_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IN35_HUMAN
  • C9JGX1
  • Q92984
  • Q99537
  • Q9BV98
sequenceLength 286
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P80217
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