UniProt:O14879 IFIT3

chain
  • chain:1-490
checksum B9F042D4DF7151D2
comment
  • FUNCTION IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.SUBUNIT Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3 (PubMed:21642987). Interacts with IFIT1 and IFIT2 (PubMed:21190939, PubMed:21642987). Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and RIGI (PubMed:21813773). Interacts with COPS5 (PubMed:17050680).INTERACTION Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.INDUCTION By type I interferons, dsRNAs and viruses.SIMILARITY Belongs to the IFIT family.
crossReference
databaseName UniProt
dbId 57172
description
  • recommendedName: Interferon-induced protein with tetratricopeptide repeats 3 shortName: IFIT-3 alternativeName: CIG49 alternativeName: ISG-60 alternativeName: Interferon-induced 60 kDa protein shortName: IFI-60K alternativeName: Interferon-induced protein with tetratricopeptide repeats 4 shortName: IFIT-4 alternativeName: Retinoic acid-induced gene G protein shortName: P60 shortName: RIG-G
displayName UniProt:O14879 IFIT3
geneName
  • IFIT3
  • CIG-49
  • IFI60
  • IFIT4
  • ISG60
identifier O14879
isSequenceChanged false
keyword
  • 3D-structure
  • Antiviral defense
  • Cytoplasm
  • Immunity
  • Innate immunity
  • Mitochondrion
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • TPR repeat
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • IFIT3
otherIdentifier
  • 11731407_x_at
  • 16707184
  • 204747_PM_at
  • 204747_at
  • 229450_PM_at
  • 229450_at
  • 3257208
  • 3257209
  • 3257210
  • 3257213
  • 3257214
  • 3257215
  • 3257217
  • 3437
  • 38584_at
  • 62330_at
  • 7929052
  • A_23_P35412
  • A_33_P3283611
  • GO:0002376
  • GO:0003674
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0008285
  • GO:0009615
  • GO:0012501
  • GO:0042802
  • GO:0043066
  • GO:0043226
  • GO:0045087
  • GO:0051607
  • GO:0098542
  • GO:0140374
  • HMNXSV003008517
  • Hs.296083.0.A1_3p_at
  • ILMN_1664543
  • ILMN_1701789
  • ILMN_2239754
  • PH_hs_0010750
  • TC10000637.hg
  • U52513_at
  • g4504586_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IFIT3_HUMAN
  • Q99634
  • Q9BSK7
sequenceLength 490
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O14879
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