Protein acetylation, which can occur during or after polypep...

created [InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
dbId 5691503
displayName Protein acetylation, which can occur during or after polypep...
modified [InstanceEdit:6783376] Jassal, Bijay, 2015-06-12
schemaClass Summation
text Protein acetylation, which can occur during or after polypeptide chain biosynthesis, helps protect the intracellular proteins from proteolysis. Acylamino-acid-releasing enzyme (APEH) is a cytosolic enzyme able to catalyse the preferential hydrolysis of terminal acetylated amino acids from small acetylated peptides. APEH prefers substrates with acetylated methionine, alanine and serine residues. Hydrolysis produces an acetylated amino acid and a N-terminus protein (Jones et al. 1991). APEH expression is reduced in renal cell carcinoma therefore may represent a tumor suppressor gene, whose loss contributes to the development of renal cell carcinoma (Erlandsson et al. 1991). The hydrolysis of an acetylated serine residue (NAc-Ser-protein) is shown here.
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