UniProt:P00451 F8

chain
  • signal peptide:1-19
  • chain:20-2351
  • chain:20-1332
  • chain:20-759
  • chain:760-1332
  • chain:1668-2351
checksum 75FB6A2955C74CB0
comment
  • FUNCTION Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.SUBUNIT Interacts with VWF/vWF. vWF binding is essential for the stabilization of F8 in circulation.DOMAIN Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity.PTM Sulfation on Tyr-1699 is essential for binding vWF.PHARMACEUTICAL Available under the names Kogenate (Bayer) and Recombinate (Baxter and American Home Products). Used to treat hemophilia A.SIMILARITY Belongs to the multicopper oxidase family.
crossReference
databaseName UniProt
dbId 54602
description
  • recommendedName: Coagulation factor VIII alternativeName: Antihemophilic factor shortName:AHF alternativeName: Procoagulant component component recommendedName: Factor VIIIa heavy chain, 200 kDa isoform /component component recommendedName: Factor VIIIa heavy chain, 92 kDa isoform /component component recommendedName: Factor VIII B chain /component component recommendedName: Factor VIIIa light chain /component
displayName UniProt:P00451 F8
geneName
  • F8
  • F8C
identifier P00451
isSequenceChanged false
keyword
  • 3D-structure
  • Acute phase
  • Alternative splicing
  • Blood coagulation
  • Calcium
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Hemophilia
  • Hemostasis
  • Metal-binding
  • Pharmaceutical
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Sulfation
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • F8
otherIdentifier
  • 0002690746
  • 0003140338
  • 0004200086
  • 11722979_a_at
  • 11722980_a_at
  • 11752341_a_at
  • 17115729
  • 205756_s_at
  • 2157
  • 37550_at
  • 4027640
  • 4027641
  • 4027642
  • 4027643
  • 4027644
  • 4027645
  • 4027646
  • 4027648
  • 4027649
  • 4027650
  • 4027651
  • 4027652
  • 4027659
  • 4027660
  • 4027661
  • 4027662
  • 4027663
  • 4027664
  • 4027665
  • 4027666
  • 4027667
  • 4027668
  • 4027669
  • 4027670
  • 4027672
  • 4027674
  • 4027675
  • 4027676
  • 4027677
  • 4027678
  • 4027680
  • 4027681
  • 4027682
  • 4027683
  • 4027686
  • 4027689
  • 4027690
  • 4027691
  • 8176193
  • A_23_P217643
  • A_24_P314451
  • GE57825
  • GO:0002576
  • GO:0003674
  • GO:0005507
  • GO:0005515
  • GO:0005575
  • GO:0005576
  • GO:0005615
  • GO:0005622
  • GO:0005737
  • GO:0005783
  • GO:0005788
  • GO:0005794
  • GO:0005796
  • GO:0005886
  • GO:0006810
  • GO:0006888
  • GO:0006950
  • GO:0006953
  • GO:0007596
  • GO:0007597
  • GO:0007599
  • GO:0008150
  • GO:0016192
  • GO:0016491
  • GO:0022607
  • GO:0030134
  • GO:0031093
  • GO:0031410
  • GO:0033116
  • GO:0043167
  • GO:0043226
  • GO:0046872
  • GO:0048208
  • GO:0055114
  • GO:0061024
  • GO:0065003
  • GO:2000267
  • HMNXSV003018712
  • ILMN_1670229
  • ILMN_1675083
  • ILMN_1691584
  • ILMN_2370622
  • ILMN_3233263
  • M14113_at
  • PH_hs_0024930
  • TC0X001547.hg
  • g10518504_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FA8_HUMAN
  • Q14286
  • Q5HY69
sequenceLength 2351
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P00451

Referrals

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