UniProt:Q92731 ESR2

chain
  • chain:1-530
checksum 8CAE34215992418A
comment
  • FUNCTION Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).SUBUNIT Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with UBE1C. Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1 promoter. Interacts with DNAAF4 (By similarity). Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with RBM39, in the presence of estradiol (E2) (By similarity).DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.PTM Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.SIMILARITY Belongs to the nuclear hormone receptor family. NR3 subfamily.CAUTION Had previously been shown to interact with PELP1. However this paper was retracted as cell-based data was viewed as unreliable.
crossReference
databaseName UniProt
dbId 54472
description
  • recommendedName: Estrogen receptor beta shortName:ER-beta alternativeName: Nuclear receptor subfamily 3 group A member 2
displayName UniProt:Q92731 ESR2
geneName
  • ESR2
  • ESTRB
  • NR3A2
identifier Q92731
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • Disease variant
  • DNA-binding
  • Lipid-binding
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Steroid-binding
  • Transcription
  • Transcription regulation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • ESR2
otherIdentifier
  • 0003870452
  • 11741669_a_at
  • 11741670_x_at
  • 11741983_a_at
  • 11747111_x_at
  • 11750908_a_at
  • 11762037_x_at
  • 11762046_at
  • 1442_at
  • 16793759
  • 2100
  • 210780_3p_at
  • 210780_at
  • 211117_x_at
  • 211118_x_at
  • 211120_x_at
  • 240777_at
  • 31436_s_at
  • 31437_r_at
  • 34431_at
  • 3568199
  • 3568200
  • 3568201
  • 3568202
  • 3568203
  • 3568204
  • 3568205
  • 3568206
  • 3568207
  • 3568208
  • 3568216
  • 3568218
  • 3568219
  • 3568221
  • 3568222
  • 3568223
  • 3568225
  • 3568226
  • 3568227
  • 3568228
  • 3568229
  • 3568232
  • 3568233
  • 3568234
  • 3568235
  • 3568238
  • 3568239
  • 3568240
  • 3568241
  • 3568244
  • 3568248
  • 3568250
  • 3568251
  • 3568252
  • 46979_at
  • 7979583
  • A_23_P54100
  • A_33_P3347911
  • GE54563
  • GO:0000122
  • GO:0000785
  • GO:0000978
  • GO:0000981
  • GO:0003674
  • GO:0003677
  • GO:0003700
  • GO:0003707
  • GO:0004879
  • GO:0005496
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0005737
  • GO:0005739
  • GO:0006355
  • GO:0006357
  • GO:0006367
  • GO:0007165
  • GO:0007267
  • GO:0008150
  • GO:0008270
  • GO:0008289
  • GO:0009058
  • GO:0019899
  • GO:0030284
  • GO:0030308
  • GO:0030518
  • GO:0030520
  • GO:0034056
  • GO:0034641
  • GO:0040007
  • GO:0043167
  • GO:0043226
  • GO:0043565
  • GO:0045893
  • GO:0045944
  • GO:0046872
  • GO:0048019
  • GO:0051091
  • GO:0071392
  • GO:2000272
  • HMNXSV003049641
  • Hs.194486.0.A1_3p_at
  • ILMN_1740045
  • ILMN_2390457
  • PH_hs_0025883
  • PH_hs_0036203
  • X99101_at
  • g2911151_3p_at
  • g2961558_3p_s_at
  • g3345671_3p_at
  • g4894662_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ESR2_HUMAN
  • A8K8K5
  • G3V5M5
  • O60608
  • O60685
  • O60702
  • O60703
  • O75583
  • O75584
  • Q0MWT5
  • Q0MWT6
  • Q86Z31
  • Q9UEV6
  • Q9UHD3
  • Q9UQK9
sequenceLength 530
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q92731

Referrals

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