UniProt:P21709 EPHA1

chain
  • signal peptide:1-25
  • chain:26-976
checksum 91EFCA69FFE17826
comment
  • FUNCTION Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.CATALYTIC ACTIVITY ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]SUBUNIT Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.SUBCELLULAR LOCATION Overexpressed in several carcinomas.PTM Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.PTM Ubiquitinated.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
crossReference
databaseName UniProt
dbId 54362
description
  • recommendedName: Ephrin type-A receptor 1 shortName: hEpha1 ecNumber: 2.7.10.1 alternativeName: EPH tyrosine kinase alternativeName: EPH tyrosine kinase 1 alternativeName: Erythropoietin-producing hepatoma receptor alternativeName: Tyrosine-protein kinase receptor EPH
displayName UniProt:P21709 EPHA1
geneName
  • EPHA1
  • EPH
  • EPHT
  • EPHT1
identifier P21709
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Angiogenesis
  • ATP-binding
  • Cell adhesion
  • Cell membrane
  • Glycoprotein
  • Kinase
  • Membrane
  • Nucleotide-binding
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transferase
  • Transmembrane
  • Transmembrane helix
  • Tyrosine-protein kinase
  • Ubl conjugation
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • EPHA1
otherIdentifier
  • 1108_s_at
  • 11723373_a_at
  • 11751296_a_at
  • 17063948
  • 2041
  • 205977_PM_s_at
  • 205977_s_at
  • 3077323
  • 3077324
  • 3077325
  • 3077326
  • 3077328
  • 3077329
  • 3077330
  • 3077331
  • 3077333
  • 3077334
  • 3077337
  • 3077340
  • 3077343
  • 3077344
  • 3077345
  • 3077346
  • 3077347
  • 3077348
  • 3077349
  • 3077350
  • 3077351
  • 3077355
  • 3077357
  • 3077360
  • 3077361
  • 8143575
  • A_23_P157333
  • GE62812
  • GO:0000166
  • GO:0001525
  • GO:0001954
  • GO:0001968
  • GO:0003824
  • GO:0004672
  • GO:0004713
  • GO:0004714
  • GO:0005003
  • GO:0005005
  • GO:0005515
  • GO:0005524
  • GO:0005886
  • GO:0006468
  • GO:0006469
  • GO:0007010
  • GO:0007155
  • GO:0007166
  • GO:0007169
  • GO:0008284
  • GO:0016020
  • GO:0016301
  • GO:0016310
  • GO:0016740
  • GO:0018108
  • GO:0019901
  • GO:0023052
  • GO:0030335
  • GO:0030336
  • GO:0034446
  • GO:0036211
  • GO:0043087
  • GO:0043235
  • GO:0045766
  • GO:0046777
  • GO:0048013
  • GO:0048856
  • GO:0048870
  • GO:0051496
  • GO:0060089
  • GO:0090630
  • GO:0140096
  • HMNXSV003006546
  • ILMN_1664265
  • M18391_s_at
  • PH_hs_0005023
  • TC07001971.hg
  • g4885208_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EPHA1_HUMAN
  • A1L3V3
  • B5A966
  • B5A967
  • Q15405
sequenceLength 976
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P21709
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