UniProt:P11161 EGR2

chain
  • chain:1-476
checksum 7810D1B1B418DF1F
comment
  • FUNCTION Sequence-specific DNA-binding transcription factor (PubMed:17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).FUNCTION E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.PATHWAY Protein modification; protein sumoylation.SUBUNIT Interacts with HCFC1 (PubMed:14532282). Interacts with WWP2 (PubMed:19651900). Interacts with UBC9 (PubMed:21836637). Interacts with CITED1 (By similarity). Interacts (via phosphorylated form) with SFN (By similarity).SUBCELLULAR LOCATION Ubiquitinated by WWP2 leading to proteasomal degradation.PTM Acetylated at Lys-247. May be deacetylated by HDAC6, HDAC10 or SIRT1.DISEASE The disease is caused by variants affecting the gene represented in this entry. Patients affected by the amyelinating form carry a causative, homozygous deletion encompassing a myelin-specific enhancer of EGR2 (PubMed:22522483).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the EGR C2H2-type zinc-finger protein family.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 54216
description
  • recommendedName: E3 SUMO-protein ligase EGR2 ecNumber evidence="14"2.3.2.- alternativeName: AT591 alternativeName: fullName evidence="23"E3 SUMO-protein transferase ERG2 alternativeName: Early growth response protein 2 shortName: EGR-2 alternativeName: Zinc finger protein Krox-20
displayName UniProt:P11161 EGR2
geneName
  • EGR2
  • KROX20
identifier P11161
isSequenceChanged false
keyword
  • Acetylation
  • Activator
  • Alternative splicing
  • Charcot-Marie-Tooth disease
  • Dejerine-Sottas syndrome
  • Disease variant
  • DNA-binding
  • Metal-binding
  • Neurodegeneration
  • Neuropathy
  • Nucleus
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Transferase
  • Ubl conjugation
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • EGR2
otherIdentifier
  • 11722728_a_at
  • 11734811_a_at
  • 11756832_a_at
  • 16714776
  • 1959
  • 3291602
  • 3291603
  • 3291604
  • 3291605
  • 3291606
  • 3291611
  • 3291612
  • 3291613
  • 3291614
  • 37863_at
  • 7933872
  • A_23_P46936
  • GE80912
  • GO:0000785
  • GO:0000976
  • GO:0000978
  • GO:0000981
  • GO:0001228
  • GO:0003677
  • GO:0003682
  • GO:0003700
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0005737
  • GO:0006351
  • GO:0006355
  • GO:0006357
  • GO:0006611
  • GO:0006886
  • GO:0006913
  • GO:0007420
  • GO:0007422
  • GO:0007611
  • GO:0007622
  • GO:0008045
  • GO:0010467
  • GO:0014037
  • GO:0014040
  • GO:0016740
  • GO:0016925
  • GO:0021569
  • GO:0021612
  • GO:0021659
  • GO:0021660
  • GO:0021665
  • GO:0021666
  • GO:0023052
  • GO:0030154
  • GO:0030278
  • GO:0031625
  • GO:0031643
  • GO:0032868
  • GO:0035284
  • GO:0035904
  • GO:0035914
  • GO:0036211
  • GO:0042552
  • GO:0043226
  • GO:0043231
  • GO:0043565
  • GO:0045444
  • GO:0045893
  • GO:0045944
  • GO:0046872
  • GO:0048168
  • GO:0048856
  • GO:0050877
  • GO:0061629
  • GO:0061665
  • GO:0071310
  • GO:0071837
  • GO:0140096
  • GO:0140110
  • GO:1990837
  • HMNXSV003008803
  • J04076_at
  • PH_hs_0000185
  • g9845523_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EGR2_HUMAN
  • B2R724
  • B3KRD7
  • Q68CZ5
  • Q8IV26
  • Q9UNA6
sequenceLength 476
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P11161
Cite Us!