UniProt:P15538 CYP11B1

chain
  • transit peptide:1-24
  • chain:25-503
checksum 0B36D82513960EE9
comment
  • FUNCTION A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:18215163). Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively (PubMed:18215163). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:18215163).PATHWAY Steroid biosynthesis; glucocorticoid biosynthesis.PATHWAY Steroid hormone biosynthesis.SIMILARITY Belongs to the cytochrome P450 family.
crossReference
databaseName UniProt
dbId 52698
description
  • recommendedName: Cytochrome P450 11B1, mitochondrial alternativeName: CYPXIB1 alternativeName: Cytochrome P-450c11 shortName:Cytochrome P450C11 alternativeName: fullName evidence="24"Steroid 11-beta-hydroxylase, CYP11B1 ecNumber evidence="7"1.14.15.4/ecNumber
displayName UniProt:P15538 CYP11B1
geneName
  • CYP11B1
  • S11BH
identifier P15538
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Congenital adrenal hyperplasia
  • Direct protein sequencing
  • Disease variant
  • Heme
  • Iron
  • Lipid biosynthesis
  • Lipid metabolism
  • Membrane
  • Metal-binding
  • Mitochondrion
  • Mitochondrion inner membrane
  • Monooxygenase
  • Oxidoreductase
  • Reference proteome
  • Steroid biosynthesis
  • Steroidogenesis
  • Transit peptide
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • CYP11B1
otherIdentifier
  • 0001450092
  • 11734127_a_at
  • 11734128_a_at
  • 1412_g_at
  • 1552493_s_at
  • 1584
  • 214610_at
  • 3157216
  • 3157218
  • 3157219
  • 3157220
  • 3157221
  • 3157222
  • 3157223
  • 3157225
  • 3157226
  • 3157228
  • 3157231
  • 3157232
  • 3157233
  • 3157234
  • 3157235
  • 3157237
  • 3157238
  • 3157239
  • 3157247
  • 3157249
  • 3157251
  • 3157255
  • 3157257
  • 34548_at
  • 34549_g_at
  • 79018_at
  • 8153363
  • A_23_P168928
  • A_24_P329424
  • GE59810
  • GO:0002376
  • GO:0003013
  • GO:0003674
  • GO:0004497
  • GO:0004507
  • GO:0005506
  • GO:0005575
  • GO:0005622
  • GO:0005737
  • GO:0005739
  • GO:0005743
  • GO:0006629
  • GO:0006694
  • GO:0006700
  • GO:0006704
  • GO:0006955
  • GO:0008150
  • GO:0008203
  • GO:0008217
  • GO:0009058
  • GO:0016020
  • GO:0016125
  • GO:0016491
  • GO:0016705
  • GO:0020037
  • GO:0032342
  • GO:0032870
  • GO:0034650
  • GO:0034651
  • GO:0035865
  • GO:0042592
  • GO:0042593
  • GO:0043167
  • GO:0043226
  • GO:0044281
  • GO:0046872
  • GO:0047783
  • GO:0055114
  • GO:0071375
  • HMNXSV003012949
  • HMNXSV003041760
  • Hs.301118.0.S2_3p_at
  • Hs2.377912.1.S1_3p_s_at
  • ILMN_1801917
  • ILMN_2358436
  • M32879_at
  • M32879_s_at
  • PH_hs_0035658
  • TC08001708.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • C11B1_HUMAN
  • Q14095
  • Q4VAQ8
  • Q4VAQ9
  • Q9UML2
sequenceLength 503
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P15538
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