Reactome | UniProt:Q9UBF2 COPG2

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UniProt:Q9UBF2 COPG2 Show undefined attributes

chain	chain:1-871
checksum	D361A0E74069CBEB
comment	FUNCTION The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).SUBUNIT Oligomeric complex. Binds to CDC42. Interacts with JAGN1. Interacts with TMED10 (via cytoplasmic domain) (PubMed:11056392).SUBCELLULAR LOCATION The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi.ALTERNATIVE PRODUCTS Belongs to the COPG family.
crossReference	[DatabaseIdentifier:10972412] Pharos - Targets:Q9UBF2 [DatabaseIdentifier:11055090] OpenTargets:ENSG00000158623 [DatabaseIdentifier:11608681] RefSeq:NP_001276962.1 [DatabaseIdentifier:11608683] RefSeq:NP_036265.3 [DatabaseIdentifier:11812792] PRO:Q9UBF2 [DatabaseIdentifier:11844001] GeneCards:Q9UBF2 [DatabaseIdentifier:11888485] HMDB Protein:HMDBP08334 [DatabaseIdentifier:11895193] HPA:ENSG00000158623-COPG2 [DatabaseIdentifier:12001514] Ensembl:ENST00000330992 [DatabaseIdentifier:12001515] Ensembl:ENSP00000331218 [DatabaseIdentifier:12001516] Ensembl:ENSP00000402346 [DatabaseIdentifier:12001517] Ensembl:ENST00000425248 [DatabaseIdentifier:12001518] Ensembl:ENSG00000158623
databaseName	UniProt
dbId	52694
description	recommendedName: Coatomer subunit gamma-2 alternativeName: Gamma-2-coat protein shortName: Gamma-2-COP
displayName	UniProt:Q9UBF2 COPG2
geneName	COPG2
identifier	Q9UBF2
isSequenceChanged	false
keyword	Alternative splicing Cytoplasm Cytoplasmic vesicle ER-Golgi transport Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Repeat Transport
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	COPG2
otherIdentifier	11728705_at 11747220_a_at 17062906 223457_PM_at 223457_at 233569_PM_at 233569_at 26958 3072631 3072632 3072633 3072634 3072635 3072637 3072639 3072641 3072650 3072651 3072652 3072653 3072668 3072669 3072670 3072671 3072675 3072676 77933_at 8142945 A_23_P61280 GE80515 GO:0000139 GO:0005198 GO:0005737 GO:0005783 GO:0005789 GO:0005793 GO:0005794 GO:0005829 GO:0006886 GO:0006888 GO:0006890 GO:0006891 GO:0007018 GO:0009306 GO:0015031 GO:0016020 GO:0016192 GO:0030117 GO:0030126 GO:0030133 GO:0030137 GO:0030426 GO:0030663 GO:0031090 GO:0031410 GO:0043226 GO:0072384 HMNXSV003012213 HMNXSV003019568 Hs.6421.1.A1_3p_at Hs2.145223.1.S1_3p_s_at ILMN_1809496 PH_hs_0013578 TC07003379.hg g11094284_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6810962] COPG2 [endoplasmic reticulum membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6808753] COPG2 [transport vesicle] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6807747] COPG2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6808751] COPG2 [Golgi membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000529] ENSEMBL:ENSG00000158623 COPG2 [ReferenceDNASequence:11032574] KEGG Gene (Homo sapiens):26958 COPG2 [ReferenceDNASequence:11251266] NCBI Gene:26958 COPG2 [ReferenceDNASequence:11251267] BioGPS Gene:26958 COPG2 [ReferenceDNASequence:11251268] CTD Gene:26958 COPG2 [ReferenceDNASequence:11251269] dbSNP Gene:26958 COPG2 [ReferenceDNASequence:11251270] Monarch:26958 COPG2 [ReferenceDNASequence:11354763] ENSEMBL_homo_sapiens_GENE:ENSG00000158623.14 COPG2 [ReferenceDNASequence:11512061] UCSC:Q9UBF2 COPG2 [ReferenceDNASequence:11801666] OMIM:604355 COPG2 [ReferenceDNASequence:11871354] HGNC:2237 COPG2 [ReferenceDNASequence:12191206] COSMIC (genes):COPG2 COPG2
referenceTranscript	[ReferenceRNASequence:11445672] RefSeq:NM_001290033.1 COPG2 [ReferenceRNASequence:11445678] RefSeq:NM_012133.5 COPG2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	COPG2_HUMAN A6NH74 Q2NLA0 Q54AC3 Q8WVW8
sequenceLength	871
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q9UBF2

Referrals

(interactor)	[UndirectedInteraction:12299821] UniProt:Q5S007 <-> UniProt:Q9UBF2 (IntAct) [UndirectedInteraction:12283787] UniProt:P13569 <-> UniProt:Q9UBF2 (IntAct) [UndirectedInteraction:12223307] UniProt:P03372 <-> UniProt:Q9UBF2 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6810962] COPG2 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-6808753] COPG2 [transport vesicle] [EntityWithAccessionedSequence:R-HSA-6807747] COPG2 [cytosol] [EntityWithAccessionedSequence:R-HSA-6808751] COPG2 [Golgi membrane]