created | [InstanceEdit:5246642] Rothfels, K, 2014-01-22 |
dbId | 5246643 |
displayName | The tumor suppressor APC is a central component of the destr... |
modified | [InstanceEdit:5545665] Rothfels, Karen, 2014-05-22 |
schemaClass | Summation |
text |
The tumor suppressor APC is a central component of the destruction complex that makes direct, functionally important contacts with a number of other destruction complex members, including AXIN, beta-catenin and GSK3 (Behrens et al, 1998; Kishida et al, 1998; Hart et al, 1998; Rubinfeld et al, 1993; Su et al, 1993; Rubinfeld et al, 1996). These protein-protein interactions are critical to APC's role in promoting the proteasome-mediated degradation of beta-catenin, and are abrogated by APC truncations that are common in the vast majority of colorectal cancers (reviewed in Saito-Diaz et al, 2013; Polakis, 2000; Polakis, 2012). Cancer cells with expressing truncated forms of APC have high levels of free beta-catenin and aberrant WNT target gene expression (Morin et al, 1997; Shih et al, 2000; Roh et al, 2001). |
(summation) |
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