UniProt:Q00610-1 CLTC

chain
  • initiator methionine:
  • chain:2-1675
checksum 6C4F2D54950079E2
comment
  • FUNCTION Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872).SUBUNIT Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (PubMed:16968737). In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1 (PubMed:11532990). Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL (By similarity). Interacts with ERBB2 (PubMed:16314522). Interacts with FKBP6 (PubMed:18529014). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions; TACC3 and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582). Interacts with ATG16L1 (via N-terminus) (PubMed:20639872). Interacts with RFTN1; the interaction occurs in response to pathogens (PubMed:27022195, PubMed:21266579). Interacts with USP2 isoform 4 (PubMed:26756164). Interacts with TMEM106B (via N-terminus) (PubMed:25066864).INTERACTION Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.ALTERNATIVE PRODUCTS The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the clathrin heavy chain family.SEQUENCE CAUTION Clathrin entry
crossReference
databaseName UniProt
dbId 52274
description
  • recommendedName: fullName evidence="27 28"Clathrin heavy chain 1 alternativeName: Clathrin heavy chain on chromosome 17 shortName: CLH-17
displayName UniProt:Q00610-1 CLTC
geneName
  • CLTC
  • CLH17
  • CLTCL2
  • KIAA0034
identifier Q00610
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Autophagy
  • Cell cycle
  • Cell division
  • Coated pit
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Direct protein sequencing
  • Disease variant
  • Intellectual disability
  • Membrane
  • Mitosis
  • Phosphoprotein
  • Reference proteome
  • Repeat
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • CLTC
otherIdentifier
  • 11739027_at
  • 11739028_s_at
  • 11739029_a_at
  • 11739030_s_at
  • 11746341_a_at
  • 1213
  • 16836564
  • 200614_PM_at
  • 200614_at
  • 3728897
  • 3728898
  • 3729173
  • 3729174
  • 3729175
  • 3729177
  • 3729178
  • 3729179
  • 3729181
  • 3729183
  • 3729184
  • 3729186
  • 3729188
  • 3729189
  • 3729190
  • 3729191
  • 3729193
  • 3729194
  • 3729195
  • 3729196
  • 3729197
  • 3729199
  • 3729201
  • 3729202
  • 3729203
  • 3729204
  • 3729205
  • 3729206
  • 3729207
  • 3729208
  • 3729209
  • 3729210
  • 3729211
  • 3729212
  • 3729213
  • 3729214
  • 3729216
  • 3729218
  • 3729223
  • 3729224
  • 3729225
  • 3729226
  • 3729227
  • 3729228
  • 3729229
  • 3729230
  • 41159_at
  • 8008834
  • 84461_at
  • 91168_at
  • A_14_P116029
  • A_14_P122089
  • A_23_P118544
  • A_33_P3274731
  • A_33_P3353170
  • D21260_at
  • GE57114
  • GO:0000278
  • GO:0001649
  • GO:0003723
  • GO:0003725
  • GO:0005198
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005737
  • GO:0005764
  • GO:0005768
  • GO:0005773
  • GO:0005794
  • GO:0005819
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0005905
  • GO:0005925
  • GO:0005975
  • GO:0006886
  • GO:0006898
  • GO:0006914
  • GO:0007010
  • GO:0007049
  • GO:0012505
  • GO:0016020
  • GO:0016192
  • GO:0019901
  • GO:0030118
  • GO:0030130
  • GO:0030132
  • GO:0030136
  • GO:0030154
  • GO:0030659
  • GO:0030669
  • GO:0031410
  • GO:0031623
  • GO:0032051
  • GO:0032588
  • GO:0032991
  • GO:0033572
  • GO:0036020
  • GO:0042147
  • GO:0042470
  • GO:0043226
  • GO:0045334
  • GO:0046907
  • GO:0048268
  • GO:0050750
  • GO:0051301
  • GO:0060236
  • GO:0065003
  • GO:0070062
  • GO:0071439
  • GO:0072583
  • GO:0072659
  • GO:0072686
  • GO:0097718
  • GO:0150093
  • GO:1900126
  • GO:1901135
  • GO:1903077
  • GO:1903561
  • GO:1990381
  • GO:1990498
  • HMNXSV003026476
  • HMNXSV003043633
  • ILMN_1756779
  • PH_hs_0022888
  • TC17000725.hg
  • g4758011_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • CLH1_HUMAN
  • D3DU00
  • Q6N0A0
  • Q86TF2
sequenceLength 1675
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q00610-1
variantIdentifier Q00610-1
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