Reactome | UniProt:P55283 CDH4

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UniProt:P55283 CDH4 Show undefined attributes

chain	signal peptide:1-20 propeptide:21-169 chain:170-916
checksum	E4512F94E58046D7
comment	FUNCTION Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.SUBCELLULAR LOCATION Expressed mainly in brain but also found in other tissues.DOMAIN Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
crossReference	[DatabaseIdentifier:10978972] Pharos - Targets:P55283 [DatabaseIdentifier:11077375] OpenTargets:ENSG00000179242 [DatabaseIdentifier:11612059] RefSeq:NP_001239268.1 [DatabaseIdentifier:11612063] RefSeq:NP_001785.2 [DatabaseIdentifier:11828897] PRO:P55283 [DatabaseIdentifier:11849971] GeneCards:P55283 [DatabaseIdentifier:11888024] HMDB Protein:HMDBP07520 [DatabaseIdentifier:11900626] HPA:ENSG00000179242-CDH4 [DatabaseIdentifier:12129894] Ensembl:ENSG00000179242 [DatabaseIdentifier:12129895] Ensembl:ENST00000543233 [DatabaseIdentifier:12129896] Ensembl:ENSP00000484928 [DatabaseIdentifier:12129897] Ensembl:ENST00000614565 [DatabaseIdentifier:12129898] Ensembl:ENSP00000443301
databaseName	UniProt
dbId	51216
description	recommendedName: Cadherin-4 alternativeName: Retinal cadherin shortName: R-CAD shortName: R-cadherin
displayName	UniProt:P55283 CDH4
geneName	CDH4
identifier	P55283
isSequenceChanged	false
keyword	Alternative splicing Calcium Cell adhesion Cell membrane Cleavage on pair of basic residues Glycoprotein Membrane Metal-binding Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	CDH4
otherIdentifier	1002 11755815_a_at 1483_at 16915541 206866_PM_at 206866_at 220227_PM_at 220227_at 3892090 3892091 3892093 3892133 3892172 3892173 3892174 3892184 3892185 3892202 3892207 3892221 3892234 3892249 3892259 3892260 3892261 3892266 3892269 3892275 3892276 3892278 3892279 3892326 3892328 3892330 3892331 3892332 3892334 63500_r_at 8063796 A_14_P115196 A_14_P132342 A_23_P17593 A_23_P28999 GE57729 GE85466 GO:0000902 GO:0005509 GO:0005886 GO:0005912 GO:0007043 GO:0007155 GO:0007156 GO:0007157 GO:0007411 GO:0016020 GO:0016339 GO:0016342 GO:0030154 GO:0034330 GO:0034332 GO:0044331 GO:0045296 GO:0045773 GO:0046872 GO:0048675 GO:0048856 GO:0098609 HMNXSV003024013 ILMN_1769891 L34059_at PH_hs_0012392 PH_hs_0024269 PH_hs_0035867 PH_hs_0038050 TC20000481.hg TC20001333.hg g13376328_3p_at g4502724_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-418991] CDH4 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8997042] ENSEMBL:ENSG00000179242 CDH4 [ReferenceDNASequence:11030760] KEGG Gene (Homo sapiens):1002 CDH4 [ReferenceDNASequence:11256299] NCBI Gene:1002 CDH4 [ReferenceDNASequence:11256300] BioGPS Gene:1002 CDH4 [ReferenceDNASequence:11256301] CTD Gene:1002 CDH4 [ReferenceDNASequence:11256302] dbSNP Gene:1002 CDH4 [ReferenceDNASequence:11256303] Monarch:1002 CDH4 [ReferenceDNASequence:11350851] ENSEMBL_homo_sapiens_GENE:ENSG00000179242.16 CDH4 [ReferenceDNASequence:11509265] UCSC:P55283 CDH4 [ReferenceDNASequence:11799121] OMIM:603006 CDH4 [ReferenceDNASequence:11877323] HGNC:1763 CDH4 [ReferenceDNASequence:12195933] COSMIC (genes):CDH4 CDH4
referenceTranscript	[ReferenceRNASequence:11438576] RefSeq:NM_001252339.2 CDH4 [ReferenceRNASequence:11438580] RefSeq:NM_001794.4 CDH4
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CADH4_HUMAN B3KWB8 G3V1P8 Q2M208 Q5VZ44 Q9BZ05
sequenceLength	916
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P55283

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-418991] CDH4 [plasma membrane]