Reactome | UniProt:P23560 BDNF

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UniProt:P23560 BDNF Show undefined attributes

chain	signal peptide:1-18 chain:19-247 propeptide:19-128 chain:129-247
checksum	0A60488254722A99
comment	FUNCTION Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.FUNCTION Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).SUBUNIT Monomers and homodimers. Binds to NTRK2/TRKB (PubMed:8527932, PubMed:11152678). Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (PubMed:7703225, PubMed:10631974). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2 (PubMed:24908487).INTERACTION A proportion of BDNF is secreted as immature precursor (proBDNF).ALTERNATIVE PRODUCTS 2 types of transcripts are produced: non-coding transcripts (antisense, opposite strand (OS), 8 exons) and coding transcripts (11 exons). Brain BDNF and anti-BDNF transcripts form dsRNA duplexes.TISSUE SPECIFICITY Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.PTM N-glycosylated and glycosulfated, contrary to mature BDNF.PTM Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (PubMed:11152678). Can be converted into mature BDNF by plasmin (PLG) (PubMed:19467646).SIMILARITY Belongs to the NGF-beta family.ONLINE INFORMATION BDNF entry
crossReference	[DatabaseIdentifier:10975557] Pharos - Targets:P23560 [DatabaseIdentifier:11060405] OpenTargets:ENSG00000176697 [DatabaseIdentifier:11611443] RefSeq:NP_001137277.1 [DatabaseIdentifier:11611446] RefSeq:NP_001137278.1 [DatabaseIdentifier:11611455] RefSeq:NP_001137279.1 [DatabaseIdentifier:11611456] RefSeq:NP_001137280.1 [DatabaseIdentifier:11611457] RefSeq:NP_001137281.1 [DatabaseIdentifier:11611461] RefSeq:NP_001137282.1 [DatabaseIdentifier:11611463] RefSeq:NP_001137283.1 [DatabaseIdentifier:11611469] RefSeq:NP_001137284.1 [DatabaseIdentifier:11611475] RefSeq:NP_001137285.1 [DatabaseIdentifier:11611481] RefSeq:NP_001137286.1 [DatabaseIdentifier:11611487] RefSeq:NP_001137288.1 [DatabaseIdentifier:11611493] RefSeq:NP_001700.2 [DatabaseIdentifier:11611499] RefSeq:NP_733927.1 [DatabaseIdentifier:11611504] RefSeq:NP_733928.1 [DatabaseIdentifier:11611510] RefSeq:NP_733929.1 [DatabaseIdentifier:11611519] RefSeq:NP_733930.1 [DatabaseIdentifier:11611525] RefSeq:NP_733931.1 [DatabaseIdentifier:11611532] RefSeq:XP_011518582.1 [DatabaseIdentifier:11749502] PDB:1B8M [DatabaseIdentifier:11749509] PDB:1BND [DatabaseIdentifier:11821674] PRO:P23560 [DatabaseIdentifier:11844681] GeneCards:P23560 [DatabaseIdentifier:11899020] HPA:ENSG00000176697-BDNF [DatabaseIdentifier:12015568] Ensembl:ENST00000314915 [DatabaseIdentifier:12015569] Ensembl:ENSG00000176697 [DatabaseIdentifier:12015570] Ensembl:ENSP00000432727 [DatabaseIdentifier:12015571] Ensembl:ENST00000525528 [DatabaseIdentifier:12015572] Ensembl:ENSP00000379309 [DatabaseIdentifier:12015573] Ensembl:ENSP00000349084 [DatabaseIdentifier:12015574] Ensembl:ENST00000395978 [DatabaseIdentifier:12015575] Ensembl:ENSP00000379305 [DatabaseIdentifier:12015576] Ensembl:ENSP00000437138 [DatabaseIdentifier:12015577] Ensembl:ENSP00000379307 [DatabaseIdentifier:12015578] Ensembl:ENST00000533246 [DatabaseIdentifier:12015579] Ensembl:ENSP00000379302 [DatabaseIdentifier:12015580] Ensembl:ENST00000418212 [DatabaseIdentifier:12015581] Ensembl:ENST00000532997 [DatabaseIdentifier:12015582] Ensembl:ENST00000439476 [DatabaseIdentifier:12015583] Ensembl:ENSP00000389345 [DatabaseIdentifier:12015584] Ensembl:ENST00000356660 [DatabaseIdentifier:12015585] Ensembl:ENSP00000400502 [DatabaseIdentifier:12015586] Ensembl:ENST00000525950 [DatabaseIdentifier:12015587] Ensembl:ENSP00000435805 [DatabaseIdentifier:12015588] Ensembl:ENST00000438929 [DatabaseIdentifier:12015589] Ensembl:ENST00000395986 [DatabaseIdentifier:12015590] Ensembl:ENST00000533131 [DatabaseIdentifier:12015591] Ensembl:ENSP00000414303 [DatabaseIdentifier:12015592] Ensembl:ENST00000395983 [DatabaseIdentifier:12015593] Ensembl:ENST00000530861 [DatabaseIdentifier:12015594] Ensembl:ENST00000395981 [DatabaseIdentifier:12015595] Ensembl:ENSP00000320002 [DatabaseIdentifier:12015596] Ensembl:ENSP00000432035 [DatabaseIdentifier:12015597] Ensembl:ENSP00000432376 [DatabaseIdentifier:12015598] Ensembl:ENSP00000435564
databaseName	UniProt
dbId	50786
description	recommendedName: Brain-derived neurotrophic factor shortName: BDNF alternativeName: Abrineurin component recommendedName: fullName evidence="25"BDNF precursor form shortName evidence="25"ProBDNF /component
displayName	UniProt:P23560 BDNF
geneName	BDNF
identifier	P23560
isSequenceChanged	false
keyword	3D-structure Alternative promoter usage Alternative splicing Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	BDNF
otherIdentifier	1088_at 11733750_a_at 11733751_s_at 11734642_a_at 11735902_a_at 11753244_a_at 206382_PM_s_at 206382_s_at 239367_PM_at 239367_at 3367232 3367233 3367234 3367235 3367236 3367237 3367238 3367239 3367240 3367241 3367242 3367243 3367244 3367245 3367246 3367247 3367248 3367249 3367250 3367251 3367253 3367254 3367255 3367262 3367263 3367264 3367265 3367266 3367267 3367269 3367270 3367271 3367272 3367273 3367274 40023_at 627 7947230 82966_at A_23_P127891 A_32_P7316 GE81060 GO:0005102 GO:0005163 GO:0005515 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005788 GO:0007165 GO:0007169 GO:0007399 GO:0007411 GO:0007416 GO:0007422 GO:0007613 GO:0008021 GO:0008083 GO:0010832 GO:0010976 GO:0012501 GO:0021675 GO:0023052 GO:0030154 GO:0030424 GO:0030425 GO:0031410 GO:0031547 GO:0031550 GO:0033138 GO:0034330 GO:0036211 GO:0038180 GO:0043226 GO:0043524 GO:0045664 GO:0048018 GO:0048471 GO:0048668 GO:0048672 GO:0048812 GO:0048856 GO:0050804 GO:0050877 GO:0051965 GO:0098772 GO:1900122 GO:2000008 GO:2001234 HMNXSV003022207 Hs.146442.0.A1_3p_at ILMN_1706644 ILMN_1712712 ILMN_1719820 ILMN_1751276 ILMN_1761910 ILMN_1793988 M61176_at PH_hs_0026545 PH_hs_0026546 PH_hs_0028454 TC11003090.hg g4502392_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-187041] BDNF(1-247) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-167028] BDNF [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993486] ENSEMBL:ENSG00000176697 BDNF [ReferenceDNASequence:11024361] KEGG Gene (Homo sapiens):627 BDNF [ReferenceDNASequence:11254125] NCBI Gene:627 BDNF [ReferenceDNASequence:11254126] BioGPS Gene:627 BDNF [ReferenceDNASequence:11254127] CTD Gene:627 BDNF [ReferenceDNASequence:11254128] dbSNP Gene:627 BDNF [ReferenceDNASequence:11254129] Monarch:627 BDNF [ReferenceDNASequence:11350058] ENSEMBL_homo_sapiens_GENE:ENSG00000176697.20 BDNF [ReferenceDNASequence:11514168] UCSC:P23560 BDNF [ReferenceDNASequence:11795582] OMIM:113505 BDNF [ReferenceDNASequence:11872035] HGNC:1033 BDNF [ReferenceDNASequence:12190259] COSMIC (genes):BDNF BDNF
referenceTranscript	[ReferenceRNASequence:11455177] RefSeq:NM_001143805.1 BDNF [ReferenceRNASequence:11455190] RefSeq:NM_001143806.1 BDNF [ReferenceRNASequence:11455192] RefSeq:NM_001143807.1 BDNF [ReferenceRNASequence:11455193] RefSeq:NM_001143808.1 BDNF [ReferenceRNASequence:11455203] RefSeq:NM_001143809.1 BDNF [ReferenceRNASequence:11455205] RefSeq:NM_001143810.1 BDNF [ReferenceRNASequence:11455215] RefSeq:NM_001143811.1 BDNF [ReferenceRNASequence:11455217] RefSeq:NM_001143812.1 BDNF [ReferenceRNASequence:11455229] RefSeq:NM_001143813.1 BDNF [ReferenceRNASequence:11455231] RefSeq:NM_001143814.1 BDNF [ReferenceRNASequence:11455242] RefSeq:NM_001143816.1 BDNF [ReferenceRNASequence:11455244] RefSeq:NM_001709.4 BDNF [ReferenceRNASequence:11455254] RefSeq:NM_170731.4 BDNF [ReferenceRNASequence:11455255] RefSeq:NM_170732.4 BDNF [ReferenceRNASequence:11455257] RefSeq:NM_170733.3 BDNF [ReferenceRNASequence:11455268] RefSeq:NM_170734.3 BDNF [ReferenceRNASequence:11455270] RefSeq:NM_170735.5 BDNF [ReferenceRNASequence:11455280] RefSeq:XM_011520280.2 BDNF
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BDNF_HUMAN A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24
sequenceLength	247
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P23560

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-187041] BDNF(1-247) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-167028] BDNF [extracellular region]
(interactor)	[UndirectedInteraction:12232185] UniProt:P23560 <-> UniProt:P34130 (IntAct)