UniProt:P51572 BCAP31

chain
  • initiator methionine:1
  • chain:2-246
checksum D34367F870D6EB00
comment
  • FUNCTION Functions as a chaperone protein (PubMed:9396746, PubMed:18287538). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671).SUBUNIT Homodimer and heterodimer with BCAP29 (PubMed:9334338, PubMed:23967155). Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1 (PubMed:9334338, PubMed:11917123, PubMed:31206022). Forms a complex (via C-terminus) with TOMM40 which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria; within the complex BCAP31 interacts directly with unprocessed and processed NDUFS4 and NDUFB11 (PubMed:31206022). Interacts with VDAC1 (PubMed:31206022). Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins (By similarity). Interacts with HACD2 (PubMed:15024066).SUBUNIT (Microbial infection) Interacts (via C-terminus) with HRSV membrane protein SH; this interaction is direct.TISSUE SPECIFICITY Ubiquitous. Highly expressed in neurons and discrete endocrine cells.PTM Cleaved by CASP8 and other caspases.DISEASE BCAP31 is deleted in the chromosome Xq28 deletion syndrome which involves BCAP31 and the and the promoter region of ABCD1.SIMILARITY Belongs to the BCAP29/BCAP31 family.
crossReference
databaseName UniProt
dbId 50653
description
  • recommendedName: B-cell receptor-associated protein 31 shortName:BCR-associated protein 31 shortName:Bap31 alternativeName: 6C6-AG tumor-associated antigen alternativeName: Protein CDM alternativeName: p28
displayName UniProt:P51572 BCAP31
geneName
  • BCAP31
  • BAP31
  • DXS1357E
identifier P51572
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Coiled coil
  • Deafness
  • Direct protein sequencing
  • Dystonia
  • Endoplasmic reticulum
  • ER-Golgi transport
  • Host-virus interaction
  • Membrane
  • Mental retardation
  • Protein transport
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • BCAP31
otherIdentifier
  • 0002320471
  • 10134
  • 11715422_a_at
  • 11715423_s_at
  • 11715424_x_at
  • 11741191_a_at
  • 17115207
  • 17121378
  • 17121380
  • 17121504
  • 200837_at
  • 3657757
  • 3657759
  • 3657762
  • 3657765
  • 3658174
  • 3658176
  • 3658178
  • 3658181
  • 3689503
  • 3689506
  • 3689508
  • 4026668
  • 4026670
  • 4026671
  • 4026672
  • 4026673
  • 4026676
  • 4026677
  • 4026678
  • 4026689
  • 4026690
  • 4026693
  • 4026694
  • 4026697
  • 4026698
  • 4026699
  • 4026700
  • 4026701
  • 4026702
  • 4026703
  • 4026704
  • 4026705
  • 4026706
  • 41724_at
  • 75139_s_at
  • 8175835
  • A_24_P134683
  • GE80206
  • GO:0000003
  • GO:0000139
  • GO:0002376
  • GO:0002474
  • GO:0003674
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005737
  • GO:0005739
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0005811
  • GO:0005829
  • GO:0005886
  • GO:0005887
  • GO:0006605
  • GO:0006626
  • GO:0006810
  • GO:0006886
  • GO:0006888
  • GO:0006915
  • GO:0006950
  • GO:0007005
  • GO:0007165
  • GO:0007204
  • GO:0007283
  • GO:0008150
  • GO:0008219
  • GO:0009056
  • GO:0015031
  • GO:0016020
  • GO:0016021
  • GO:0016032
  • GO:0016192
  • GO:0030136
  • GO:0031410
  • GO:0032471
  • GO:0032580
  • GO:0033116
  • GO:0034976
  • GO:0035584
  • GO:0042288
  • GO:0042592
  • GO:0043226
  • GO:0043280
  • GO:0044233
  • GO:0044403
  • GO:0044877
  • GO:0051561
  • GO:0070973
  • GO:0071556
  • GO:0097038
  • GO:1903071
  • GO:1904154
  • GO:2001244
  • HMNXSV003014085
  • ILMN_1812403
  • PH_hs_0024339
  • TC0X001516.hg
  • TC0X002285.hg
  • X81817_at
  • g10047078_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BAP31_HUMAN
  • B3KQ79
  • D3DWV5
  • Q13836
  • Q96CF0
sequenceLength 246
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P51572

Referrals

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