Reactome | UniProt:P05412 JUN

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UniProt:P05412 JUN Show undefined attributes

chain	chain:1-331
checksum	0695E23AC4D33561
comment	FUNCTION Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).FUNCTION (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression.SUBUNIT Heterodimer with either BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). Heterodimer with FOS (By similarity). Heterodimer with FOSB isoform 1 and 2 (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with FOS and FOSB isoform 1 and 2 (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527). Interacts with TSC22D3 (via N-terminus); the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478). Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781). Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748). Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463). Found in a complex with PRR7 and FBXW7 (PubMed:27458189). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with RBM39 (By similarity). Interacts with PAGE4 (PubMed:24263171, PubMed:24559171, PubMed:26242913). Interacts with ARK2N and CSNK2B; the interaction with ARK2N is mediated by CSNK2B (PubMed:31341047).INTERACTION Expressed in the developing and adult prostate and prostate cancer cells.PTM Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).PTM Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.PTM Acetylated at Lys-271 by EP300.SIMILARITY Belongs to the bZIP family. Jun subfamily.
crossReference	[DatabaseIdentifier:10977971] Pharos - Targets:P05412 [DatabaseIdentifier:11063035] OpenTargets:ENSG00000177606 [DatabaseIdentifier:11626628] RefSeq:NP_002219.1 [DatabaseIdentifier:11790680] PDB:1A02 [DatabaseIdentifier:11790681] PDB:1FOS [DatabaseIdentifier:11790682] PDB:1JNM [DatabaseIdentifier:11790683] PDB:1JUN [DatabaseIdentifier:11790684] PDB:1S9K [DatabaseIdentifier:11790685] PDB:1T2K [DatabaseIdentifier:11790686] PDB:5FV8 [DatabaseIdentifier:11790687] PDB:5T01 [DatabaseIdentifier:11790688] PDB:6Y3V [DatabaseIdentifier:11820809] PRO:P05412 [DatabaseIdentifier:11845994] GeneCards:P05412 [DatabaseIdentifier:11853697] ZINC - Substances:JUN_HUMAN [DatabaseIdentifier:11857801] ZINC - Metabolites:JUN_HUMAN [DatabaseIdentifier:11858756] ZINC - Biogenic:JUN_HUMAN [DatabaseIdentifier:11860070] ZINC - Investigational:JUN_HUMAN [DatabaseIdentifier:11862491] ZINC - Predictions - Purchasable:JUN_HUMAN [DatabaseIdentifier:11865655] ZINC target:P05412 [DatabaseIdentifier:11889294] HMDB Protein:HMDBP02090 [DatabaseIdentifier:11898074] HPA:ENSG00000177606-JUN [DatabaseIdentifier:12043841] Ensembl:ENSP00000503132 [DatabaseIdentifier:12043842] Ensembl:ENST00000678696 [DatabaseIdentifier:12043843] Ensembl:ENSP00000360266 [DatabaseIdentifier:12043844] Ensembl:ENSG00000177606 [DatabaseIdentifier:12043845] Ensembl:ENST00000371222
databaseName	UniProt
dbId	50080
description	recommendedName: fullName evidence="33"Transcription factor Jun alternativeName: Activator protein 1 shortName: AP1 alternativeName: Proto-oncogene c-Jun alternativeName: fullName evidence="33"Transcription factor AP-1 subunit Jun alternativeName: V-jun avian sarcoma virus 17 oncogene homolog alternativeName: p39
displayName	UniProt:P05412 JUN
geneName	JUN
identifier	P05412
isSequenceChanged	false
keyword	3D-structure Acetylation Activator Direct protein sequencing DNA-binding Isopeptide bond Nucleus Phosphoprotein Proto-oncogene Reference proteome Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	JUN
otherIdentifier	11718394_at 11718395_s_at 11718396_x_at 11718397_s_at 16687875 201464_PM_x_at 201464_x_at 201465_PM_s_at 201465_s_at 201466_PM_s_at 201466_s_at 2415046 2415049 2415085 2415086 2415087 2415088 2415089 2415090 2415091 2415092 2415093 2415094 2415095 2415096 2415097 2415098 2415099 2415100 2415101 2415102 2415105 32583_at 3725 7916609 89913_s_at A_23_P201538 A_33_P3323298 GE57500 GO:0000122 GO:0000228 GO:0000785 GO:0000791 GO:0000976 GO:0000978 GO:0000981 GO:0001227 GO:0001228 GO:0003677 GO:0003690 GO:0003700 GO:0003723 GO:0005096 GO:0005515 GO:0005634 GO:0005654 GO:0005667 GO:0005694 GO:0006351 GO:0006355 GO:0006357 GO:0007179 GO:0012501 GO:0019046 GO:0019899 GO:0023052 GO:0031625 GO:0034614 GO:0035497 GO:0035976 GO:0042127 GO:0042802 GO:0043065 GO:0043226 GO:0043392 GO:0043922 GO:0043923 GO:0044389 GO:0045892 GO:0045893 GO:0045944 GO:0051726 GO:0060395 GO:0061629 GO:0070412 GO:0071276 GO:0090575 GO:0098772 GO:0140110 GO:0140296 GO:0140467 GO:1902895 GO:1904707 GO:1990441 GO:1990837 GO:2000144 HMNXSV003055749 Hs.78465.0.S2_3p_a_at ILMN_1806023 PH_hs_0004525 TC01002708.hg g12803622_3p_s_at g7710122_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-450250] JUN [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-450237] p-S63,S73-JUN [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-168194] JUN [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8868682] p-S63,S73-JUN [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8994286] ENSEMBL:ENSG00000177606 JUN [ReferenceDNASequence:11032684] KEGG Gene (Homo sapiens):3725 JUN [ReferenceDNASequence:11283277] NCBI Gene:3725 JUN [ReferenceDNASequence:11283278] BioGPS Gene:3725 JUN [ReferenceDNASequence:11283279] CTD Gene:3725 JUN [ReferenceDNASequence:11283280] dbSNP Gene:3725 JUN [ReferenceDNASequence:11283281] Monarch:3725 JUN [ReferenceDNASequence:11354079] ENSEMBL_homo_sapiens_GENE:ENSG00000177606.9 JUN [ReferenceDNASequence:11519501] UCSC:P05412 JUN [ReferenceDNASequence:11803946] OMIM:165160 JUN [ReferenceDNASequence:11873346] HGNC:6204 JUN [ReferenceDNASequence:12195243] COSMIC (genes):JUN JUN
referenceTranscript	[ReferenceRNASequence:11465209] RefSeq:NM_002228.3 JUN
schemaClass	ReferenceGeneProduct
secondaryIdentifier	JUN_HUMAN Q6FHM7 Q96G93
sequenceLength	331
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P05412

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-450250] JUN [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450237] p-S63,S73-JUN [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-168194] JUN [cytosol] [EntityWithAccessionedSequence:R-HSA-8868682] p-S63,S73-JUN [cytosol]
(referenceSequence)	[ModifiedResidue:168397] phosphorylated residue at unknown position [ModifiedResidue:168361] O-phospho-L-serine at 63 [ModifiedResidue:450265] O-phospho-L-serine at 73
(interactor)	[UndirectedInteraction:12212121] UniProt:P05412 <-> UniProt:P17535 (IntAct) [UndirectedInteraction:12212119] UniProt:P05412 <-> UniProt:P46060 (IntAct) [UndirectedInteraction:12212117] UniProt:P05412 <-> UniProt:P14868 (IntAct) [UndirectedInteraction:12212115] UniProt:P05412 <-> UniProt:P26640 (IntAct) [UndirectedInteraction:12212113] UniProt:P05412 <-> UniProt:Q969G3 (IntAct) [UndirectedInteraction:12212111] UniProt:P05412 <-> UniProt:O15226 (IntAct) [UndirectedInteraction:12212109] UniProt:P05412 <-> UniProt:Q92922 (IntAct) [UndirectedInteraction:12212107] UniProt:P05412 <-> UniProt:P35453 (IntAct) [UndirectedInteraction:12212103] UniProt:P05412 <-> UniProt:Q02930 (IntAct) [UndirectedInteraction:12212099] UniProt:P05412 <-> UniProt:P41252 (IntAct) [UndirectedInteraction:12212097] UniProt:P05412 <-> UniProt:Q14596 (IntAct) [UndirectedInteraction:12212095] UniProt:P05412 <-> UniProt:Q29RF7 (IntAct) [UndirectedInteraction:12212093] UniProt:P05412 <-> UniProt:Q9UPN9 (IntAct) [UndirectedInteraction:12212091] UniProt:P05412 <-> UniProt:Q00005 (IntAct) [UndirectedInteraction:12212089] UniProt:P05412 <-> UniProt:Q12824 (IntAct) [UndirectedInteraction:12212087] UniProt:P05412 <-> UniProt:Q92945 (IntAct) [UndirectedInteraction:12212085] UniProt:P05412 <-> UniProt:P17482 (IntAct) [UndirectedInteraction:12212081] UniProt:P05412 <-> IntAct:EBI-10041773 (IntAct) [UndirectedInteraction:12212077] UniProt:P05412 <-> UniProt:Q02078 (IntAct) [UndirectedInteraction:12212075] UniProt:P05412 <-> UniProt:P29692 (IntAct) [UndirectedInteraction:12212073] UniProt:P05412 <-> UniProt:P53539 (IntAct) [UndirectedInteraction:12212071] UniProt:P05412 <-> UniProt:Q8TAQ2 (IntAct) [UndirectedInteraction:12212069] UniProt:P05412 <-> UniProt:P16220 (IntAct) [UndirectedInteraction:12212067] UniProt:P05412 <-> UniProt:P49916 (IntAct) [UndirectedInteraction:12212065] UniProt:P05412 <-> UniProt:P28347 (IntAct) [UndirectedInteraction:12212063] UniProt:P05412 <-> IntAct:EBI-10042615 (IntAct) [UndirectedInteraction:12212059] UniProt:P05412 <-> UniProt:P18846 (IntAct) [UndirectedInteraction:12212057] UniProt:P05412 <-> UniProt:Q00987 (IntAct) [UndirectedInteraction:12212055] UniProt:P05412 <-> UniProt:Q8IWZ6 (IntAct) [UndirectedInteraction:12212053] UniProt:P05412 <-> UniProt:P48634 (IntAct) [UndirectedInteraction:12212051] UniProt:P05412 <-> UniProt:Q99966 (IntAct) [UndirectedInteraction:12212049] UniProt:P05412 <-> UniProt:Q9UPY8 (IntAct) [UndirectedInteraction:12212047] UniProt:P05412 <-> UniProt:P14921 (IntAct) [UndirectedInteraction:12212045] UniProt:P05412 <-> UniProt:P56279 (IntAct) [UndirectedInteraction:12212041] UniProt:P05412 <-> UniProt:Q9NRL3 (IntAct) [UndirectedInteraction:12212037] UniProt:P05412 <-> UniProt:O43889 (IntAct) [UndirectedInteraction:12212035] UniProt:P05412 <-> UniProt:P56671 (IntAct) [UndirectedInteraction:12212031] UniProt:P05412 <-> IntAct:EBI-5590876 (IntAct) [UndirectedInteraction:12212027] UniProt:P05412 <-> IntAct:EBI-2677274 (IntAct) [UndirectedInteraction:12212023] UniProt:P05412 <-> UniProt:Q15311 (IntAct) [UndirectedInteraction:12212021] UniProt:P05412 <-> UniProt:Q02930-2 (IntAct) [UndirectedInteraction:12212017] UniProt:P05412 <-> UniProt:P17275 (IntAct) [UndirectedInteraction:12212015] UniProt:P05412 <-> UniProt:Q9Y4X5 (IntAct) [UndirectedInteraction:12212013] UniProt:P05412 <-> UniProt:Q9UJY5 (IntAct) [UndirectedInteraction:12212011] UniProt:P05412 <-> UniProt:P22607 (IntAct) [UndirectedInteraction:12212009] UniProt:P05412 <-> UniProt:Q8WTV0 (IntAct) [UndirectedInteraction:12212007] UniProt:P05412 <-> UniProt:P78563 (IntAct) [UndirectedInteraction:12212005] UniProt:P05412 <-> UniProt:Q9UMX0 (IntAct) [UndirectedInteraction:12212003] UniProt:P05412 <-> IntAct:EBI-25872354 (IntAct) [UndirectedInteraction:12211999] UniProt:P05412 <-> UniProt:P27986-2 (IntAct) [UndirectedInteraction:12211997] UniProt:P05412 <-> UniProt:Q9UGL9 (IntAct) [UndirectedInteraction:12211995] UniProt:P05412 <-> UniProt:P06396 (IntAct) [UndirectedInteraction:12211993] UniProt:P05412 <-> UniProt:I6L9F6 (IntAct) [UndirectedInteraction:12211991] UniProt:P05412 <-> UniProt:P0C746 (IntAct) [UndirectedInteraction:12211987] UniProt:P05412 <-> UniProt:Q9DGW5 (IntAct) [UndirectedInteraction:12211983] UniProt:P05412 <-> UniProt:Q15796 (IntAct) [UndirectedInteraction:12211981] UniProt:P05412 <-> UniProt:Q71U36 (IntAct) [UndirectedInteraction:12211979] UniProt:P05412 <-> UniProt:Q9HD26 (IntAct) [UndirectedInteraction:12211977] UniProt:P05412 <-> UniProt:P11142 (IntAct) [UndirectedInteraction:12211975] UniProt:P05412 <-> UniProt:P07197 (IntAct) [UndirectedInteraction:12211971] UniProt:P05412 <-> UniProt:Q06481 (IntAct) [UndirectedInteraction:12211969] UniProt:P05412 <-> IntAct:EBI-10041770 (IntAct) [UndirectedInteraction:12211965] UniProt:P05412 <-> UniProt:Q8N1L9-1 (IntAct) [UndirectedInteraction:12211961] UniProt:P05412 <-> UniProt:Q13330 (IntAct) [UndirectedInteraction:12211959] UniProt:P05412 <-> UniProt:Q13469-2 (IntAct) [UndirectedInteraction:12211955] UniProt:P05412 <-> UniProt:P03129 (IntAct) [UndirectedInteraction:12211953] UniProt:P05412 <-> UniProt:Q8WYK2 (IntAct) [UndirectedInteraction:12211951] UniProt:P05412 <-> UniProt:O95644 (IntAct) [UndirectedInteraction:12211949] UniProt:P05412 <-> UniProt:Q16520 (IntAct) [UndirectedInteraction:12211947] UniProt:P05412 <-> UniProt:Q8NHY2 (IntAct) [UndirectedInteraction:12211945] UniProt:P05412 <-> UniProt:P52292 (IntAct) [UndirectedInteraction:12211943] UniProt:P05412 <-> UniProt:P17544 (IntAct) [UndirectedInteraction:12211939] UniProt:P05412 <-> UniProt:P10809 (IntAct) [UndirectedInteraction:12211937] UniProt:P05412 <-> UniProt:P20042 (IntAct) [UndirectedInteraction:12211935] UniProt:P05412 <-> UniProt:P63000 (IntAct) [UndirectedInteraction:12211933] UniProt:P05412 <-> UniProt:Q13885 (IntAct) [UndirectedInteraction:12211931] UniProt:P05412 <-> UniProt:Q99986 (IntAct) [UndirectedInteraction:12211929] UniProt:P05412 <-> UniProt:P05067 (IntAct) [UndirectedInteraction:12211927] UniProt:P05412 <-> UniProt:P07900 (IntAct) [UndirectedInteraction:12211925] UniProt:P05412 <-> UniProt:P18848 (IntAct) [UndirectedInteraction:12211923] UniProt:P05412 <-> IntAct:EBI-10041487 (IntAct) [UndirectedInteraction:12211919] UniProt:P05412 <-> UniProt:P05412 (IntAct) [UndirectedInteraction:12211919] UniProt:P05412 <-> UniProt:P05412 (IntAct) [UndirectedInteraction:12211917] UniProt:P05412 <-> UniProt:P15407 (IntAct) [UndirectedInteraction:12211915] UniProt:P05412 <-> UniProt:P53779 (IntAct) [UndirectedInteraction:12211913] UniProt:P05412 <-> UniProt:Q9NR55 (IntAct) [UndirectedInteraction:12211911] UniProt:P05412 <-> UniProt:P18847 (IntAct) [UndirectedInteraction:12211909] UniProt:P05412 <-> UniProt:P45983 (IntAct) [UndirectedInteraction:12211907] UniProt:P05412 <-> UniProt:P15408 (IntAct) [UndirectedInteraction:12211905] UniProt:P05412 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:12211903] UniProt:P05412 <-> UniProt:P01100 (IntAct) [UndirectedInteraction:12211419] UniProt:Q9NR30 <-> UniProt:P05412 (IntAct) [UndirectedInteraction:12205663] UniProt:P07437 <-> UniProt:P05412 (IntAct) [UndirectedInteraction:12204669] UniProt:P0CG48 <-> UniProt:P05412 (IntAct) [UndirectedInteraction:12199795] UniProt:Q8WQG9 <-> UniProt:P05412 (IntAct)

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