UniProt:P05412 JUN

chain
  • chain:1-331
checksum 0695E23AC4D33561
comment
  • FUNCTION Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).SUBUNIT Heterodimer with either FOS or BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527). Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478). Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781). Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748). Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463). Found in a complex with PRR7 and FBXW7 (PubMed:27458189). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with RBM39 (By similarity). Interacts with PAGE4 (PubMed:24263171, PubMed:24559171, PubMed:26242913).TISSUE SPECIFICITY Expressed in the developing and adult prostate and prostate cancer cells.PTM Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).PTM Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.PTM Acetylated at Lys-271 by EP300.SIMILARITY Belongs to the bZIP family. Jun subfamily.
crossReference
databaseName UniProt
dbId 50080
description
  • recommendedName: Transcription factor AP-1 alternativeName: Activator protein 1 shortName:AP1 alternativeName: Proto-oncogene c-Jun alternativeName: V-jun avian sarcoma virus 17 oncogene homolog alternativeName: p39
displayName UniProt:P05412 JUN
geneName
  • JUN
identifier P05412
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Activator
  • Direct protein sequencing
  • DNA-binding
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proto-oncogene
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • JUN
otherIdentifier
  • 0003130112
  • 11718394_at
  • 11718395_s_at
  • 11718396_x_at
  • 11718397_s_at
  • 16687875
  • 201464_x_at
  • 201465_s_at
  • 201466_s_at
  • 2415046
  • 2415085
  • 2415086
  • 2415087
  • 2415088
  • 2415089
  • 2415090
  • 2415091
  • 2415092
  • 2415093
  • 2415094
  • 2415095
  • 2415096
  • 2415097
  • 2415098
  • 2415099
  • 2415100
  • 2415101
  • 2415102
  • 2415105
  • 32583_at
  • 3725
  • 7916609
  • 89913_s_at
  • A_23_P201538
  • A_33_P3323298
  • GE57500
  • GO:0000122
  • GO:0000228
  • GO:0000785
  • GO:0000791
  • GO:0000976
  • GO:0000978
  • GO:0000981
  • GO:0001102
  • GO:0001227
  • GO:0001228
  • GO:0001525
  • GO:0001836
  • GO:0002376
  • GO:0003674
  • GO:0003677
  • GO:0003690
  • GO:0003700
  • GO:0003723
  • GO:0005096
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005634
  • GO:0005654
  • GO:0005667
  • GO:0005694
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006351
  • GO:0006355
  • GO:0006357
  • GO:0006366
  • GO:0006950
  • GO:0007005
  • GO:0007049
  • GO:0007165
  • GO:0007179
  • GO:0007265
  • GO:0007568
  • GO:0007612
  • GO:0007623
  • GO:0008134
  • GO:0008150
  • GO:0008219
  • GO:0008283
  • GO:0008284
  • GO:0009058
  • GO:0009314
  • GO:0009612
  • GO:0010033
  • GO:0014070
  • GO:0019899
  • GO:0030154
  • GO:0030234
  • GO:0031625
  • GO:0032496
  • GO:0032991
  • GO:0033613
  • GO:0034097
  • GO:0034614
  • GO:0034641
  • GO:0035497
  • GO:0035976
  • GO:0038095
  • GO:0042127
  • GO:0042493
  • GO:0042542
  • GO:0042802
  • GO:0043065
  • GO:0043226
  • GO:0043392
  • GO:0043525
  • GO:0043547
  • GO:0043565
  • GO:0043922
  • GO:0043923
  • GO:0044389
  • GO:0044403
  • GO:0044877
  • GO:0045657
  • GO:0045740
  • GO:0045892
  • GO:0045893
  • GO:0045944
  • GO:0048646
  • GO:0048661
  • GO:0048856
  • GO:0050877
  • GO:0051090
  • GO:0051365
  • GO:0051591
  • GO:0051726
  • GO:0051899
  • GO:0060395
  • GO:0070412
  • GO:0071276
  • GO:0071837
  • GO:1902895
  • GO:1904707
  • GO:1990441
  • GO:1990837
  • GO:2000144
  • HMNXSV003055749
  • Hs.78465.0.S2_3p_a_at
  • ILMN_1669768
  • ILMN_1806023
  • PH_hs_0004525
  • TC01002708.hg
  • g12803622_3p_s_at
  • g7710122_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • JUN_HUMAN
  • Q6FHM7
  • Q96G93
sequenceLength 331
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P05412

Referrals

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