UniProt:P15514 AREG

chain
  • signal peptide:1-19
  • propeptide:20-100
  • chain:101-187
  • propeptide:188-252
checksum 68C1FA6BCD4D2BED
comment
  • FUNCTION Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.SUBUNIT The immature precursor interacts with CNIH.INTERACTION By phorbol 12-myristate 13-acetate (PMA).MISCELLANEOUS AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.SIMILARITY Belongs to the amphiregulin family.
crossReference
databaseName UniProt
dbId 49956
description
  • recommendedName: fullName evidence="8"Amphiregulin shortName evidence="8"AR alternativeName: fullName evidence="7"Colorectum cell-derived growth factor shortName evidence="7"CRDGF
displayName UniProt:P15514 AREG
geneName
  • AREG
  • AREGB
  • SDGF
identifier P15514
isSequenceChanged false
keyword
  • 3D-structure
  • Cytokine
  • Direct protein sequencing
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Growth factor
  • Membrane
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • AREG
otherIdentifier
  • 11715306_s_at
  • 16967853
  • 16967863
  • 205239_PM_at
  • 205239_at
  • 2731541
  • 2731543
  • 2731544
  • 2731545
  • 2731546
  • 2731547
  • 2731548
  • 2731552
  • 2731553
  • 2731554
  • 2731555
  • 2731556
  • 2731558
  • 2731561
  • 34898_at
  • 374
  • 8095736
  • 8095744
  • A_14_P115708
  • A_23_P259071
  • A_33_P3419190
  • GE62938
  • GO:0005125
  • GO:0005154
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005634
  • GO:0005737
  • GO:0005783
  • GO:0005789
  • GO:0007173
  • GO:0007186
  • GO:0007267
  • GO:0008083
  • GO:0008284
  • GO:0009986
  • GO:0010838
  • GO:0012507
  • GO:0014009
  • GO:0014070
  • GO:0016020
  • GO:0022414
  • GO:0023052
  • GO:0030154
  • GO:0030297
  • GO:0030669
  • GO:0031175
  • GO:0031410
  • GO:0032355
  • GO:0033116
  • GO:0036211
  • GO:0038134
  • GO:0042327
  • GO:0042542
  • GO:0043226
  • GO:0043434
  • GO:0045668
  • GO:0048018
  • GO:0048856
  • GO:0050731
  • GO:0051384
  • GO:0051591
  • GO:0060598
  • GO:0060744
  • GO:0060749
  • GO:0060750
  • GO:0098772
  • HMNXSV003029092
  • M30703_s_at
  • PH_hs_0013934
  • PH_hs_0035731
  • TC04002952.hg
  • TC04002953.hg
  • g4502198_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AREG_HUMAN
  • Q5U026
sequenceLength 252
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P15514
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