Reactome | UniProt:P05062 ALDOB

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UniProt:P05062 ALDOB Show undefined attributes

chain	initiator methionine: chain:2-364
checksum	DCE314E7AC5586CA
comment	FUNCTION Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041).CATALYTIC ACTIVITY beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphateCATALYTIC ACTIVITY beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphateBIOPHYSICOCHEMICAL PROPERTIES Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.PATHWAY Carbohydrate biosynthesis; gluconeogenesis.PATHWAY Carbohydrate metabolism; fructose metabolism.SUBUNIT Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7 (PubMed:18000879). Forms a ternary complex with G6PD and TP53; this interaction is direct (PubMed:35122041).INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.SIMILARITY Belongs to the class I fructose-bisphosphate aldolase family.
crossReference	[DatabaseIdentifier:10970621] Pharos - Targets:P05062 [DatabaseIdentifier:11051009] OpenTargets:ENSG00000136872 [DatabaseIdentifier:11607496] RefSeq:NP_000026.2 [DatabaseIdentifier:11728043] PDB:1QO5 [DatabaseIdentifier:11728051] PDB:1XDL [DatabaseIdentifier:11728053] PDB:1XDM [DatabaseIdentifier:11728062] PDB:8D44 [DatabaseIdentifier:11808420] PRO:P05062 [DatabaseIdentifier:11842176] GeneCards:P05062 [DatabaseIdentifier:11881746] Orphanet:15492 [DatabaseIdentifier:11888463] HMDB Protein:HMDBP00980 [DatabaseIdentifier:11893057] HPA:ENSG00000136872-ALDOB [DatabaseIdentifier:11962008] Ensembl:ENSP00000497731 [DatabaseIdentifier:11962009] Ensembl:ENST00000648064 [DatabaseIdentifier:11962010] Ensembl:ENST00000647789 [DatabaseIdentifier:11962011] Ensembl:ENSP00000497990 [DatabaseIdentifier:11962012] Ensembl:ENSG00000136872 [DatabaseIdentifier:11962013] Ensembl:ENSP00000497767 [DatabaseIdentifier:11962014] Ensembl:ENST00000648758
databaseName	UniProt
dbId	49878
description	recommendedName: Fructose-bisphosphate aldolase B ecNumber evidence="5 6 11"4.1.2.13 alternativeName: Liver-type aldolase
displayName	UniProt:P05062 ALDOB
geneName	ALDOB ALDB
identifier	P05062
isSequenceChanged	false
keyword	3D-structure Acetylation Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycolysis Lyase Phosphoprotein Reference proteome Schiff base
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	ALDOB
otherIdentifier	11739162_a_at 11739163_a_at 11750289_a_at 11750290_x_at 17096640 204704_PM_s_at 204704_s_at 204705_PM_x_at 204705_x_at 211357_PM_s_at 211357_s_at 217238_PM_s_at 217238_s_at 229 3218080 3218081 3218082 3218083 3218084 3218089 3218090 3218091 3218092 3218093 3218095 3218096 3218097 3218098 3218100 3218101 3218102 3218103 3218106 3218109 3218110 33455_at 77417_at 8162884 A_23_P32143 A_23_P415974 GE80880 GO:0003824 GO:0004332 GO:0005515 GO:0005576 GO:0005615 GO:0005737 GO:0005815 GO:0005829 GO:0005856 GO:0005975 GO:0006000 GO:0006001 GO:0006091 GO:0006094 GO:0006096 GO:0006116 GO:0008092 GO:0016829 GO:0030388 GO:0032781 GO:0034451 GO:0042802 GO:0043226 GO:0051117 GO:0055086 GO:0060090 GO:0061609 GO:0061624 GO:0065003 GO:0070061 GO:0070062 GO:0070072 GO:1901135 GO:1905856 HMNXSV003053752 Hs.234234.0.S2_3p_at ILMN_1747716 M15656_at TC09001421.hg g4557306_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5656456] ALDOB A174D [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5656457] ALDOB A149P [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-70339] ALDOB [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993448] ENSEMBL:ENSG00000136872 ALDOB [ReferenceDNASequence:11032250] KEGG Gene (Homo sapiens):229 ALDOB [ReferenceDNASequence:11249271] NCBI Gene:229 ALDOB [ReferenceDNASequence:11249272] BioGPS Gene:229 ALDOB [ReferenceDNASequence:11249273] CTD Gene:229 ALDOB [ReferenceDNASequence:11249274] dbSNP Gene:229 ALDOB [ReferenceDNASequence:11249275] Monarch:229 ALDOB [ReferenceDNASequence:11354443] ENSEMBL_homo_sapiens_GENE:ENSG00000136872.21 ALDOB [ReferenceDNASequence:11511341] UCSC:P05062 ALDOB [ReferenceDNASequence:11801254] OMIM:612724 ALDOB [ReferenceDNASequence:11869533] HGNC:417 ALDOB [ReferenceDNASequence:12190541] COSMIC (genes):ALDOB ALDOB
referenceTranscript	[ReferenceRNASequence:11444063] RefSeq:NM_000035.3 ALDOB
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ALDOB_HUMAN Q13741 Q13742 Q5T7D6
sequenceLength	364
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P05062

Referrals

(interactor)	[UndirectedInteraction:12318549] UniProt:Q8NFJ9 <-> UniProt:P05062 (IntAct) [UndirectedInteraction:12293371] UniProt:Q9BXC9 <-> UniProt:P05062 (IntAct) [UndirectedInteraction:12273653] UniProt:Q96RK4 <-> UniProt:P05062 (IntAct) [UndirectedInteraction:12258475] UniProt:Q8IWZ6 <-> UniProt:P05062 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5656456] ALDOB A174D [cytosol] [EntityWithAccessionedSequence:R-HSA-5656457] ALDOB A149P [cytosol] [EntityWithAccessionedSequence:R-HSA-70339] ALDOB [cytosol]
(referenceSequence)	[ReplacedResidue:5656449] L-alanine 174 replaced with L-aspartic acid [ReplacedResidue:5656454] L-alanine 149 replaced with L-proline