UniProt:Q15758 SLC1A5

chain
  • chain:1-541
checksum AD61C789CCFFE934
comment
  • FUNCTION Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).FUNCTION (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.FUNCTION (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.FUNCTION (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.SUBUNIT Homotrimer (Probable) (PubMed:29872227). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).TISSUE SPECIFICITY Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.SIMILARITY Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
crossReference
databaseName UniProt
dbId 49368
description
  • recommendedName: Neutral amino acid transporter B(0) shortName:ATB(0) alternativeName: Baboon M7 virus receptor alternativeName: RD114/simian type D retrovirus receptor alternativeName: Sodium-dependent neutral amino acid transporter type 2 alternativeName: Solute carrier family 1 member 5
displayName UniProt:Q15758 SLC1A5
geneName
  • SLC1A5
  • ASCT2
  • M7V1
  • RDR
  • RDRC
identifier Q15758
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative initiation
  • Alternative splicing
  • Amino-acid transport
  • Cell membrane
  • Glycoprotein
  • Host cell receptor for virus entry
  • Host-virus interaction
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Sodium
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • SLC1A5
otherIdentifier
  • 0007000390
  • 11716865_a_at
  • 11716866_x_at
  • 11740714_a_at
  • 16873632
  • 208916_at
  • 3866277
  • 3866278
  • 3866279
  • 3866280
  • 3866281
  • 3866282
  • 3866283
  • 3866284
  • 3866285
  • 3866286
  • 3866289
  • 3866290
  • 3866291
  • 3866292
  • 3866294
  • 3866295
  • 3866296
  • 3866297
  • 3866298
  • 3866299
  • 3866300
  • 3866301
  • 41778_at
  • 6510
  • 8037835
  • GE62526
  • GE84300
  • GO:0001618
  • GO:0003013
  • GO:0003674
  • GO:0005515
  • GO:0005575
  • GO:0005576
  • GO:0005615
  • GO:0005622
  • GO:0005737
  • GO:0005886
  • GO:0005887
  • GO:0006810
  • GO:0006865
  • GO:0006868
  • GO:0008150
  • GO:0009925
  • GO:0010585
  • GO:0015175
  • GO:0015183
  • GO:0015186
  • GO:0015194
  • GO:0015293
  • GO:0015804
  • GO:0015825
  • GO:0016020
  • GO:0016021
  • GO:0016032
  • GO:0022607
  • GO:0022857
  • GO:0031410
  • GO:0038023
  • GO:0042470
  • GO:0043167
  • GO:0043226
  • GO:0044403
  • GO:0046718
  • GO:0046872
  • GO:0055085
  • GO:0065003
  • GO:0070062
  • GO:0070207
  • GO:0140009
  • GO:0150104
  • GO:1903803
  • HMNXSV003014972
  • HMNXSV003053880
  • ILMN_1707720
  • PH_hs_0010825
  • TC19001656.hg
  • U53347_at
  • g4191561_3p_at
  • g4191561_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AAAT_HUMAN
  • A8K9H5
  • B4DR77
  • B4DWS4
  • B7ZB81
  • D0EYG6
  • E9PC01
  • O95720
  • Q96RL9
  • Q9BWQ3
  • Q9UNP2
sequenceLength 541
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q15758
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