UniProt:Q9NRG9 AAAS

chain
  • initiator methionine:
  • chain:2-546
checksum E0F4E7145D8C192E
comment
  • FUNCTION Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606).SUBUNIT Interacts with NDC1, the interaction is required for nuclear pore localization (PubMed:19782045). Interacts with the inactive form aurora kinase AURKA (PubMed:26246606). Interacts with PGRMC2 (PubMed:27754849).SUBCELLULAR LOCATION In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606). The localization to the spindle is microtubule-mediated (PubMed:26246606).ALTERNATIVE PRODUCTS Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Ubiquitously expressed.
crossReference
databaseName UniProt
dbId 49366
description
  • recommendedName: Aladin alternativeName: Adracalin
displayName UniProt:Q9NRG9 AAAS
geneName
  • AAAS
  • ADRACALA
  • GL003
identifier Q9NRG9
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • Cytoskeleton
  • Disease variant
  • mRNA transport
  • Nuclear pore complex
  • Nucleus
  • Phosphoprotein
  • Protein transport
  • Reference proteome
  • Repeat
  • Translocation
  • Transport
  • WD repeat
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • AAAS
otherIdentifier
  • 11716958_a_at
  • 16765284
  • 218075_PM_at
  • 218075_at
  • 3456131
  • 3456133
  • 3456135
  • 3456136
  • 3456137
  • 3456138
  • 3456139
  • 3456140
  • 3456141
  • 3456142
  • 3456144
  • 3456146
  • 3456148
  • 3456150
  • 3456151
  • 3456153
  • 3456154
  • 3456155
  • 65445_at
  • 7963646
  • 8086
  • GE55635
  • GO:0000278
  • GO:0000922
  • GO:0001578
  • GO:0003674
  • GO:0005515
  • GO:0005634
  • GO:0005635
  • GO:0005643
  • GO:0005654
  • GO:0005737
  • GO:0005813
  • GO:0005815
  • GO:0005829
  • GO:0005856
  • GO:0006913
  • GO:0007010
  • GO:0007059
  • GO:0007612
  • GO:0009566
  • GO:0015031
  • GO:0016020
  • GO:0022414
  • GO:0031965
  • GO:0043226
  • GO:0046822
  • GO:0050877
  • GO:0051028
  • GO:0072686
  • GO:0090307
  • GO:0140014
  • HMNXSV003039478
  • ILMN_1755321
  • PH_hs_0024097
  • TC12001547.hg
  • g12962936_3p_at
  • g12962936_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AAAS_HUMAN
  • Q5JB47
  • Q9NWI6
  • Q9UG19
sequenceLength 546
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q9NRG9
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