UniProt:Q9BRX5 GINS3

chain
  • chain:1-216
checksum A1B264A72371C551
comment
  • FUNCTION Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).SUBUNIT Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4 (PubMed:17170760, PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293, PubMed:32453425). Forms a stable subcomplex with GINS2 (PubMed:17170760, PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293). GINS complex interacts with DNA primase in vitro (PubMed:17170760, PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:34700328, PubMed:34694004, PubMed:32453425).INTERACTION Associates with chromatin.ALTERNATIVE PRODUCTS This is the measured mass for the GINS complex.SIMILARITY Belongs to the GINS3/PSF3 family.
created [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
crossReference
databaseName UniProt
dbId 356315
description
  • recommendedName: DNA replication complex GINS protein PSF3 alternativeName: GINS complex subunit 3
displayName UniProt:Q9BRX5 GINS3
geneName
  • GINS3
  • PSF3
identifier Q9BRX5
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Chromosome
  • DNA replication
  • Nucleus
  • Reference proteome
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • GINS3
otherIdentifier
  • 11739763_a_at
  • 16819678
  • 218719_PM_s_at
  • 218719_s_at
  • 3663233
  • 3663234
  • 3663235
  • 3663238
  • 3663241
  • 3663242
  • 3663246
  • 3663247
  • 3663248
  • 3663249
  • 3663250
  • 3663251
  • 45633_PM_at
  • 45633_at
  • 64785
  • 7996211
  • A_23_P152136
  • A_24_P159323
  • GE56695
  • GO:0000228
  • GO:0000278
  • GO:0000811
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0006260
  • GO:0006268
  • GO:0043226
  • GO:0071162
  • GO:1902975
  • HMNXSV003006594
  • ILMN_1754272
  • PH_hs_0003351
  • TC16000502.hg
  • g12232448_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSF3_HUMAN
  • B2RDP3
  • E9PB21
  • Q9H870
sequenceLength 216
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q9BRX5
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