Reactome | UniProt:P62805 H4C1

Schema > ReferenceGeneProduct > Entries

UniProt:P62805 H4C1 Show undefined attributes

chain	initiator methionine: chain:2-103
checksum	A9E5DFD3F8B97598
comment	FUNCTION Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (PubMed:33857403). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (PubMed:33857403).INTERACTION Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.PTM Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.PTM Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.PTM Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:12086618, PubMed:15964846, PubMed:17967882). Monomethylation is performed by KMT5A/SET8 (PubMed:15964846). Dimethylation and trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity). Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526).PTM Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.PTM Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).PTM Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.PTM Sumoylated, which is associated with transcriptional repression.PTM Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.PTM Butyrylation of histones marks active promoters and competes with histone acetylation.PTM Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.PTM Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.DISEASE The disease is caused by variants affecting the gene represented in this entry. TEBIVANED1 is caused by variants in H4C3.DISEASE The disease is caused by variants affecting the gene represented in this entry. TEBIVANED2 is caused by variants in H4C11.DISEASE The disease is caused by variants affecting the gene represented in this entry. TEBIVANED3 is caused by variants in H4C5.DISEASE The disease is caused by variants affecting the gene represented in this entry. TEBIVANED4 is caused by variants in H4C9.DISEASE Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.SIMILARITY Belongs to the histone H4 family.
created	[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
crossReference	[DatabaseIdentifier:10975284] Pharos - Targets:P62805 [DatabaseIdentifier:11063810] OpenTargets:ENSG00000278637 [DatabaseIdentifier:11617010] RefSeq:NP_001029249.1 [DatabaseIdentifier:11617023] RefSeq:NP_003486.1 [DatabaseIdentifier:11617024] RefSeq:NP_003529.1 [DatabaseIdentifier:11617037] RefSeq:NP_003530.1 [DatabaseIdentifier:11617049] RefSeq:NP_003531.1 [DatabaseIdentifier:11617050] RefSeq:NP_003532.1 [DatabaseIdentifier:11617051] RefSeq:NP_003533.1 [DatabaseIdentifier:11617067] RefSeq:NP_003534.1 [DatabaseIdentifier:11617068] RefSeq:NP_003535.1 [DatabaseIdentifier:11617082] RefSeq:NP_003536.1 [DatabaseIdentifier:11617094] RefSeq:NP_003537.1 [DatabaseIdentifier:11617106] RefSeq:NP_003539.1 [DatabaseIdentifier:11617120] RefSeq:NP_068803.1 [DatabaseIdentifier:11617121] RefSeq:NP_778224.1 [DatabaseIdentifier:11758580] PDB:1ZKK [DatabaseIdentifier:11758584] PDB:2BQZ [DatabaseIdentifier:11758588] PDB:2CV5 [DatabaseIdentifier:11758592] PDB:2IG0 [DatabaseIdentifier:11758596] PDB:2KWN [DatabaseIdentifier:11758600] PDB:2KWO [DatabaseIdentifier:11758604] PDB:2LVM [DatabaseIdentifier:11758608] PDB:2QQS [DatabaseIdentifier:11758612] PDB:2RJE [DatabaseIdentifier:11758616] PDB:2RNY [DatabaseIdentifier:11758619] PDB:2RS9 [DatabaseIdentifier:11758623] PDB:3A6N [DatabaseIdentifier:11758626] PDB:3AFA [DatabaseIdentifier:11758627] PDB:3AN2 [DatabaseIdentifier:11758631] PDB:3AV1 [DatabaseIdentifier:11758638] PDB:3AV2 [DatabaseIdentifier:11758642] PDB:3AYW [DatabaseIdentifier:11758643] PDB:3AZE [DatabaseIdentifier:11758647] PDB:3AZF [DatabaseIdentifier:11758651] PDB:3AZG [DatabaseIdentifier:11758655] PDB:3AZH [DatabaseIdentifier:11758659] PDB:3AZI [DatabaseIdentifier:11758663] PDB:3AZJ [DatabaseIdentifier:11758667] PDB:3AZK [DatabaseIdentifier:11758671] PDB:3AZL [DatabaseIdentifier:11758672] PDB:3AZM [DatabaseIdentifier:11758676] PDB:3AZN [DatabaseIdentifier:11758680] PDB:3CFS [DatabaseIdentifier:11758684] PDB:3CFV [DatabaseIdentifier:11758685] PDB:3F9W [DatabaseIdentifier:11758689] PDB:3F9X [DatabaseIdentifier:11758690] PDB:3F9Y [DatabaseIdentifier:11758696] PDB:3F9Z [DatabaseIdentifier:11758700] PDB:3IJ1 [DatabaseIdentifier:11758706] PDB:3JPX [DatabaseIdentifier:11758710] PDB:3NQJ [DatabaseIdentifier:11758716] PDB:3NQU [DatabaseIdentifier:11758721] PDB:3O36 [DatabaseIdentifier:11758727] PDB:3QBY [DatabaseIdentifier:11758731] PDB:3QZS [DatabaseIdentifier:11758737] PDB:3QZT [DatabaseIdentifier:11758738] PDB:3QZV [DatabaseIdentifier:11758742] PDB:3R45 [DatabaseIdentifier:11758748] PDB:3UVW [DatabaseIdentifier:11758752] PDB:3UVX [DatabaseIdentifier:11758753] PDB:3UVY [DatabaseIdentifier:11758760] PDB:3UW9 [DatabaseIdentifier:11758764] PDB:3W96 [DatabaseIdentifier:11758770] PDB:3W97 [DatabaseIdentifier:11758774] PDB:3W98 [DatabaseIdentifier:11758783] PDB:3W99 [DatabaseIdentifier:11758789] PDB:3WA9 [DatabaseIdentifier:11758792] PDB:3WAA [DatabaseIdentifier:11758798] PDB:3WKJ [DatabaseIdentifier:11758800] PDB:3WTP [DatabaseIdentifier:11758802] PDB:3X1S [DatabaseIdentifier:11758810] PDB:3X1T [DatabaseIdentifier:11758812] PDB:3X1U [DatabaseIdentifier:11758820] PDB:3X1V [DatabaseIdentifier:11758830] PDB:4GQB [DatabaseIdentifier:11758840] PDB:4H9N [DatabaseIdentifier:11758850] PDB:4H9O [DatabaseIdentifier:11758859] PDB:4H9P [DatabaseIdentifier:11758869] PDB:4H9Q [DatabaseIdentifier:11758879] PDB:4H9R [DatabaseIdentifier:11758889] PDB:4H9S [DatabaseIdentifier:11758900] PDB:4HGA [DatabaseIdentifier:11758912] PDB:4M38 [DatabaseIdentifier:11758922] PDB:4N3W [DatabaseIdentifier:11758932] PDB:4N4F [DatabaseIdentifier:11758942] PDB:4QUT [DatabaseIdentifier:11758952] PDB:4QUU [DatabaseIdentifier:11758962] PDB:4QYD [DatabaseIdentifier:11758974] PDB:4U9W [DatabaseIdentifier:11758983] PDB:4YM5 [DatabaseIdentifier:11758993] PDB:4YM6 [DatabaseIdentifier:11759003] PDB:4YY6 [DatabaseIdentifier:11759013] PDB:4YYD [DatabaseIdentifier:11759023] PDB:4YYG [DatabaseIdentifier:11759033] PDB:4YYH [DatabaseIdentifier:11759034] PDB:4YYI [DatabaseIdentifier:11759044] PDB:4YYJ [DatabaseIdentifier:11759054] PDB:4YYK [DatabaseIdentifier:11759064] PDB:4YYM [DatabaseIdentifier:11759072] PDB:4YYN [DatabaseIdentifier:11759081] PDB:4Z2M [DatabaseIdentifier:11759092] PDB:4Z5T [DatabaseIdentifier:11759093] PDB:5AV5 [DatabaseIdentifier:11759103] PDB:5AV6 [DatabaseIdentifier:11759113] PDB:5AV8 [DatabaseIdentifier:11759123] PDB:5AV9 [DatabaseIdentifier:11759134] PDB:5AVB [DatabaseIdentifier:11759145] PDB:5AVC [DatabaseIdentifier:11759146] PDB:5AY8 [DatabaseIdentifier:11759157] PDB:5B0Y [DatabaseIdentifier:11759158] PDB:5B0Z [DatabaseIdentifier:11759167] PDB:5B24 [DatabaseIdentifier:11759177] PDB:5B2I [DatabaseIdentifier:11759187] PDB:5B2J [DatabaseIdentifier:11759197] PDB:5B31 [DatabaseIdentifier:11759207] PDB:5B32 [DatabaseIdentifier:11759208] PDB:5B33 [DatabaseIdentifier:11759218] PDB:5B40 [DatabaseIdentifier:11759219] PDB:5BNV [DatabaseIdentifier:11759229] PDB:5BNX [DatabaseIdentifier:11759240] PDB:5BO0 [DatabaseIdentifier:11759250] PDB:5C3I [DatabaseIdentifier:11759260] PDB:5CPI [DatabaseIdentifier:11759270] PDB:5CPJ [DatabaseIdentifier:11759271] PDB:5CPK [DatabaseIdentifier:11759272] PDB:5FA5 [DatabaseIdentifier:11759282] PDB:5FFW [DatabaseIdentifier:11759292] PDB:5FWE [DatabaseIdentifier:11759301] PDB:5GSE [DatabaseIdentifier:11759311] PDB:5GSU [DatabaseIdentifier:11759321] PDB:5GT0 [DatabaseIdentifier:11759330] PDB:5GT3 [DatabaseIdentifier:11759339] PDB:5GTC [DatabaseIdentifier:11759356] PDB:5GXQ [DatabaseIdentifier:11759360] PDB:5JA4 [DatabaseIdentifier:11759361] PDB:5JRG [DatabaseIdentifier:11759362] PDB:5KDM [DatabaseIdentifier:11759368] PDB:5TEG [DatabaseIdentifier:11759372] PDB:5X7X [DatabaseIdentifier:11759378] PDB:5XF3 [DatabaseIdentifier:11759382] PDB:5XF4 [DatabaseIdentifier:11759388] PDB:5XF5 [DatabaseIdentifier:11759392] PDB:5Y0C [DatabaseIdentifier:11759398] PDB:5Y0D [DatabaseIdentifier:11759403] PDB:5YE3 [DatabaseIdentifier:11759409] PDB:5YE4 [DatabaseIdentifier:11759413] PDB:5Z23 [DatabaseIdentifier:11759422] PDB:5Z30 [DatabaseIdentifier:11759426] PDB:5ZBX [DatabaseIdentifier:11759432] PDB:5ZGC [DatabaseIdentifier:11759437] PDB:6A5L [DatabaseIdentifier:11759443] PDB:6A5O [DatabaseIdentifier:11759447] PDB:6A5P [DatabaseIdentifier:11759453] PDB:6A5R [DatabaseIdentifier:11759457] PDB:6A5T [DatabaseIdentifier:11759463] PDB:6A5U [DatabaseIdentifier:11759467] PDB:6ACP [DatabaseIdentifier:11759473] PDB:6BUZ [DatabaseIdentifier:11759478] PDB:6C0W [DatabaseIdentifier:11759484] PDB:6E0C [DatabaseIdentifier:11759488] PDB:6E0P [DatabaseIdentifier:11759494] PDB:6FML [DatabaseIdentifier:11759499] PDB:6HKT [DatabaseIdentifier:11759505] PDB:6HTS [DatabaseIdentifier:11759509] PDB:6INQ [DatabaseIdentifier:11759515] PDB:6IR9 [DatabaseIdentifier:11759519] PDB:6J4W [DatabaseIdentifier:11759528] PDB:6J4X [DatabaseIdentifier:11759535] PDB:6J4Y [DatabaseIdentifier:11759537] PDB:6J4Z [DatabaseIdentifier:11759544] PDB:6J50 [DatabaseIdentifier:11759546] PDB:6J51 [DatabaseIdentifier:11759553] PDB:6JOU [DatabaseIdentifier:11759555] PDB:6JR0 [DatabaseIdentifier:11759562] PDB:6JR1 [DatabaseIdentifier:11759566] PDB:6K1I [DatabaseIdentifier:11759572] PDB:6K1J [DatabaseIdentifier:11759580] PDB:6K1K [DatabaseIdentifier:11759584] PDB:6KE9 [DatabaseIdentifier:11759589] PDB:6KVD [DatabaseIdentifier:11759594] PDB:6KXV [DatabaseIdentifier:11759599] PDB:6L49 [DatabaseIdentifier:11759603] PDB:6L4A [DatabaseIdentifier:11759607] PDB:6L9H [DatabaseIdentifier:11759617] PDB:6L9Z [DatabaseIdentifier:11759623] PDB:6LA2 [DatabaseIdentifier:11759631] PDB:6LA8 [DatabaseIdentifier:11759635] PDB:6LA9 [DatabaseIdentifier:11759644] PDB:6LAB [DatabaseIdentifier:11759648] PDB:6LE9 [DatabaseIdentifier:11759656] PDB:6LER [DatabaseIdentifier:11759660] PDB:6M3V [DatabaseIdentifier:11759670] PDB:6M44 [DatabaseIdentifier:11759674] PDB:6M4D [DatabaseIdentifier:11759682] PDB:6M4G [DatabaseIdentifier:11759686] PDB:6M4H [DatabaseIdentifier:11759694] PDB:6MLC [DatabaseIdentifier:11759698] PDB:6MUO [DatabaseIdentifier:11759706] PDB:6MUP [DatabaseIdentifier:11759712] PDB:6O1D [DatabaseIdentifier:11759720] PDB:6R0C [DatabaseIdentifier:11759724] PDB:6R8Y [DatabaseIdentifier:11759732] PDB:6R8Z [DatabaseIdentifier:11759743] PDB:6R90 [DatabaseIdentifier:11759748] PDB:6R91 [DatabaseIdentifier:11759756] PDB:6R92 [DatabaseIdentifier:11759760] PDB:6R93 [DatabaseIdentifier:11759768] PDB:6R94 [DatabaseIdentifier:11759772] PDB:6RNY [DatabaseIdentifier:11759779] PDB:6RXS [DatabaseIdentifier:11759783] PDB:6SE0 [DatabaseIdentifier:11759792] PDB:6SE6 [DatabaseIdentifier:11759796] PDB:6SEE [DatabaseIdentifier:11759804] PDB:6SEF [DatabaseIdentifier:11759808] PDB:6SEG [DatabaseIdentifier:11759815] PDB:6T79 [DatabaseIdentifier:11759820] PDB:6T7A [DatabaseIdentifier:11759828] PDB:6T7B [DatabaseIdentifier:11759832] PDB:6T7C [DatabaseIdentifier:11759840] PDB:6T7D [DatabaseIdentifier:11759844] PDB:6T90 [DatabaseIdentifier:11759852] PDB:6T93 [DatabaseIdentifier:11759856] PDB:6UPK [DatabaseIdentifier:11759864] PDB:6UPL [DatabaseIdentifier:11759868] PDB:6USJ [DatabaseIdentifier:11759869] PDB:6V2K [DatabaseIdentifier:11759877] PDB:6V92 [DatabaseIdentifier:11759882] PDB:6VO5 [DatabaseIdentifier:11759891] PDB:6X59 [DatabaseIdentifier:11759896] PDB:6X5A [DatabaseIdentifier:11759904] PDB:6XJD [DatabaseIdentifier:11759908] PDB:6Y5D [DatabaseIdentifier:11759916] PDB:6YOV [DatabaseIdentifier:11759920] PDB:7A08 [DatabaseIdentifier:11759928] PDB:7BWD [DatabaseIdentifier:11759932] PDB:7BXT [DatabaseIdentifier:11759940] PDB:7BY0 [DatabaseIdentifier:11759944] PDB:7C0M [DatabaseIdentifier:11759952] PDB:7CCQ [DatabaseIdentifier:11759956] PDB:7CCR [DatabaseIdentifier:11759964] PDB:7CIZ [DatabaseIdentifier:11759968] PDB:7CJ0 [DatabaseIdentifier:11759976] PDB:7COW [DatabaseIdentifier:11759980] PDB:7D1Z [DatabaseIdentifier:11759988] PDB:7D20 [DatabaseIdentifier:11759989] PDB:7DBP [DatabaseIdentifier:11759990] PDB:7E8D [DatabaseIdentifier:11759999] PDB:7EIC [DatabaseIdentifier:11760007] PDB:7EID [DatabaseIdentifier:11760012] PDB:7JO9 [DatabaseIdentifier:11760019] PDB:7JOA [DatabaseIdentifier:11760023] PDB:7JZV [DatabaseIdentifier:11760030] PDB:7K5X [DatabaseIdentifier:11760034] PDB:7K5Y [DatabaseIdentifier:11760041] PDB:7K60 [DatabaseIdentifier:11760045] PDB:7K61 [DatabaseIdentifier:11760052] PDB:7K63 [DatabaseIdentifier:11760057] PDB:7LMK [DatabaseIdentifier:11760065] PDB:7LMM [DatabaseIdentifier:11760069] PDB:7LYA [DatabaseIdentifier:11760077] PDB:7LYB [DatabaseIdentifier:11760081] PDB:7LYC [DatabaseIdentifier:11760090] PDB:7M98 [DatabaseIdentifier:11760094] PDB:7NL0 [DatabaseIdentifier:11760102] PDB:7PET [DatabaseIdentifier:11760106] PDB:7PEU [DatabaseIdentifier:11760115] PDB:7PEV [DatabaseIdentifier:11760119] PDB:7PEW [DatabaseIdentifier:11760127] PDB:7PEX [DatabaseIdentifier:11760128] PDB:7PEY [DatabaseIdentifier:11760134] PDB:7PEZ [DatabaseIdentifier:11760142] PDB:7PF0 [DatabaseIdentifier:11760146] PDB:7PF2 [DatabaseIdentifier:11760154] PDB:7PF3 [DatabaseIdentifier:11760158] PDB:7PF4 [DatabaseIdentifier:11760166] PDB:7PF5 [DatabaseIdentifier:11760171] PDB:7PF6 [DatabaseIdentifier:11760179] PDB:7PFA [DatabaseIdentifier:11760184] PDB:7PFC [DatabaseIdentifier:11760193] PDB:7PFD [DatabaseIdentifier:11760196] PDB:7PFE [DatabaseIdentifier:11760197] PDB:7PFF [DatabaseIdentifier:11760205] PDB:7PFT [DatabaseIdentifier:11760206] PDB:7PFU [DatabaseIdentifier:11760209] PDB:7PFV [DatabaseIdentifier:11760217] PDB:7PFW [DatabaseIdentifier:11760221] PDB:7PFX [DatabaseIdentifier:11760229] PDB:7PII [DatabaseIdentifier:11760233] PDB:7R5R [DatabaseIdentifier:11760240] PDB:7SCY [DatabaseIdentifier:11760244] PDB:7SCZ [DatabaseIdentifier:11760252] PDB:7TAN [DatabaseIdentifier:11760256] PDB:7U0G [DatabaseIdentifier:11760266] PDB:7U0I [DatabaseIdentifier:11760270] PDB:7U0J [DatabaseIdentifier:11760278] PDB:7U46 [DatabaseIdentifier:11760282] PDB:7U47 [DatabaseIdentifier:11760290] PDB:7U4D [DatabaseIdentifier:11760294] PDB:7U50 [DatabaseIdentifier:11760302] PDB:7U51 [DatabaseIdentifier:11760306] PDB:7U52 [DatabaseIdentifier:11760314] PDB:7U53 [DatabaseIdentifier:11760318] PDB:7UV9 [DatabaseIdentifier:11760326] PDB:7V1M [DatabaseIdentifier:11760329] PDB:7V6Q [DatabaseIdentifier:11760337] PDB:7V90 [DatabaseIdentifier:11760341] PDB:7V96 [DatabaseIdentifier:11760349] PDB:7V9C [DatabaseIdentifier:11760353] PDB:7V9J [DatabaseIdentifier:11760354] PDB:7V9K [DatabaseIdentifier:11760363] PDB:7V9S [DatabaseIdentifier:11760367] PDB:7VA4 [DatabaseIdentifier:11760375] PDB:7VCQ [DatabaseIdentifier:11760379] PDB:7VZ4 [DatabaseIdentifier:11760387] PDB:7W9V [DatabaseIdentifier:11760391] PDB:7WBV [DatabaseIdentifier:11760400] PDB:7WBW [DatabaseIdentifier:11760410] PDB:7WBX [DatabaseIdentifier:11760414] PDB:7X57 [DatabaseIdentifier:11760422] PDB:7X58 [DatabaseIdentifier:11760426] PDB:7XCR [DatabaseIdentifier:11760435] PDB:7XCT [DatabaseIdentifier:11760438] PDB:7XD0 [DatabaseIdentifier:11760446] PDB:7XD1 [DatabaseIdentifier:11760450] PDB:7XSE [DatabaseIdentifier:11760458] PDB:7XSX [DatabaseIdentifier:11760463] PDB:7XSZ [DatabaseIdentifier:11760472] PDB:7XT7 [DatabaseIdentifier:11760476] PDB:7XTD [DatabaseIdentifier:11760484] PDB:7XTI [DatabaseIdentifier:11760488] PDB:7XVL [DatabaseIdentifier:11760497] PDB:7XVM [DatabaseIdentifier:11760501] PDB:7XX5 [DatabaseIdentifier:11760509] PDB:7XX6 [DatabaseIdentifier:11760513] PDB:7XX7 [DatabaseIdentifier:11760522] PDB:7XZX [DatabaseIdentifier:11760526] PDB:7XZY [DatabaseIdentifier:11760533] PDB:7XZZ [DatabaseIdentifier:11760537] PDB:7Y00 [DatabaseIdentifier:11760545] PDB:7Y5U [DatabaseIdentifier:11760550] PDB:7Y5V [DatabaseIdentifier:11760558] PDB:7Y5W [DatabaseIdentifier:11760562] PDB:7Y60 [DatabaseIdentifier:11760571] PDB:7Y61 [DatabaseIdentifier:11760575] PDB:7Y7I [DatabaseIdentifier:11760583] PDB:7Y8R [DatabaseIdentifier:11760587] PDB:7YOZ [DatabaseIdentifier:11760595] PDB:7YQK [DatabaseIdentifier:11760599] PDB:7YRD [DatabaseIdentifier:11760607] PDB:7YWX [DatabaseIdentifier:11760611] PDB:7YYH [DatabaseIdentifier:11760622] PDB:7ZI4 [DatabaseIdentifier:11760632] PDB:8AAG [DatabaseIdentifier:11760636] PDB:8ATF [DatabaseIdentifier:11760644] PDB:8AV6 [DatabaseIdentifier:11760648] PDB:8B5A [DatabaseIdentifier:11760656] PDB:8B5B [DatabaseIdentifier:11760658] PDB:8B5C [DatabaseIdentifier:11760660] PDB:8DK5 [DatabaseIdentifier:11760671] PDB:8GUI [DatabaseIdentifier:11760673] PDB:8GUJ [DatabaseIdentifier:11760683] PDB:8GUK [DatabaseIdentifier:11760685] PDB:8H0V [DatabaseIdentifier:11760696] PDB:8H0W [DatabaseIdentifier:11760698] PDB:8H1T [DatabaseIdentifier:11760709] PDB:8HE5 [DatabaseIdentifier:11760713] PDB:8HLW [DatabaseIdentifier:11760724] PDB:8IEG [DatabaseIdentifier:11760726] PDB:8IEJ [DatabaseIdentifier:11760735] PDB:8IQF [DatabaseIdentifier:11760737] PDB:8IQG [DatabaseIdentifier:11760748] PDB:8J6S [DatabaseIdentifier:11760750] PDB:8J6T [DatabaseIdentifier:11760760] PDB:8JL9 [DatabaseIdentifier:11760762] PDB:8JLA [DatabaseIdentifier:11760775] PDB:8JLB [DatabaseIdentifier:11760786] PDB:8JLD [DatabaseIdentifier:11760799] PDB:8OFF [DatabaseIdentifier:11760811] PDB:8OO7 [DatabaseIdentifier:11760823] PDB:8OOA [DatabaseIdentifier:11760835] PDB:8OOP [DatabaseIdentifier:11760848] PDB:8OOS [DatabaseIdentifier:11760861] PDB:8OSJ [DatabaseIdentifier:11760873] PDB:8OSK [DatabaseIdentifier:11760875] PDB:8OSL [DatabaseIdentifier:11760885] PDB:8OTS [DatabaseIdentifier:11760887] PDB:8OTT [DatabaseIdentifier:11760897] PDB:8OX0 [DatabaseIdentifier:11760899] PDB:8OX1 [DatabaseIdentifier:11760909] PDB:8SB6 [DatabaseIdentifier:11760911] PDB:8SPS [DatabaseIdentifier:11760921] PDB:8SPU [DatabaseIdentifier:11819109] PRO:P62805 [DatabaseIdentifier:11846491] GeneCards:P62805 [DatabaseIdentifier:11864718] ZINC target:P62805 [DatabaseIdentifier:11883064] Orphanet:24599 [DatabaseIdentifier:11897206] HPA:ENSG00000197061-H4C3 [DatabaseIdentifier:11897222] HPA:ENSG00000276180-H4C9 [DatabaseIdentifier:11897232] HPA:ENSG00000275126-H4C13 [DatabaseIdentifier:11897247] HPA:ENSG00000273542-H4C12 [DatabaseIdentifier:11897256] HPA:ENSG00000276966-H4C5 [DatabaseIdentifier:11897274] HPA:ENSG00000278705-H4C2 [DatabaseIdentifier:11897283] HPA:ENSG00000278637-H4C1 [DatabaseIdentifier:11897292] HPA:ENSG00000274618-H4C6 [DatabaseIdentifier:11897302] HPA:ENSG00000277157-H4C4 [DatabaseIdentifier:11897322] HPA:ENSG00000158406-H4C8 [DatabaseIdentifier:11897337] HPA:ENSG00000270882-H4C14 [DatabaseIdentifier:11897345] HPA:ENSG00000270276-H4C15 [DatabaseIdentifier:11897364] HPA:ENSG00000197238-H4C11 [DatabaseIdentifier:11897373] HPA:ENSG00000197837-H4C16 [DatabaseIdentifier:12054595] Ensembl:ENSG00000158406 [DatabaseIdentifier:12054596] Ensembl:ENST00000611927 [DatabaseIdentifier:12054597] Ensembl:ENSG00000274618 [DatabaseIdentifier:12054598] Ensembl:ENSP00000350767 [DatabaseIdentifier:12054599] Ensembl:ENSP00000489567 [DatabaseIdentifier:12054600] Ensembl:ENSP00000484789 [DatabaseIdentifier:12054601] Ensembl:ENST00000612061 [DatabaseIdentifier:12054602] Ensembl:ENST00000578186 [DatabaseIdentifier:12054603] Ensembl:ENSG00000276966 [DatabaseIdentifier:12054604] Ensembl:ENSP00000479794 [DatabaseIdentifier:12054605] Ensembl:ENSG00000278705 [DatabaseIdentifier:12054606] Ensembl:ENSP00000478786 [DatabaseIdentifier:12054607] Ensembl:ENST00000621520 [DatabaseIdentifier:12054608] Ensembl:ENSP00000366956 [DatabaseIdentifier:12054609] Ensembl:ENST00000634956 [DatabaseIdentifier:12054610] Ensembl:ENSP00000481507 [DatabaseIdentifier:12054611] Ensembl:ENSP00000443017 [DatabaseIdentifier:12054612] Ensembl:ENSP00000367034 [DatabaseIdentifier:12054613] Ensembl:ENSP00000462355 [DatabaseIdentifier:12054614] Ensembl:ENST00000377727 [DatabaseIdentifier:12054615] Ensembl:ENST00000377803 [DatabaseIdentifier:12054616] Ensembl:ENST00000614247 [DatabaseIdentifier:12054617] Ensembl:ENST00000244537 [DatabaseIdentifier:12054618] Ensembl:ENSG00000275126 [DatabaseIdentifier:12054619] Ensembl:ENSG00000197837 [DatabaseIdentifier:12054620] Ensembl:ENSP00000479461 [DatabaseIdentifier:12054621] Ensembl:ENSP00000481343 [DatabaseIdentifier:12054622] Ensembl:ENSG00000278637 [DatabaseIdentifier:12054623] Ensembl:ENSP00000347168 [DatabaseIdentifier:12054624] Ensembl:ENST00000634560 [DatabaseIdentifier:12054625] Ensembl:ENSP00000479106 [DatabaseIdentifier:12054626] Ensembl:ENSG00000270276 [DatabaseIdentifier:12054627] Ensembl:ENSG00000273542 [DatabaseIdentifier:12054628] Ensembl:ENSG00000276180 [DatabaseIdentifier:12054629] Ensembl:ENSP00000366974 [DatabaseIdentifier:12054630] Ensembl:ENSG00000197238 [DatabaseIdentifier:12054631] Ensembl:ENSP00000480960 [DatabaseIdentifier:12054632] Ensembl:ENSP00000244537 [DatabaseIdentifier:12054633] Ensembl:ENST00000617569 [DatabaseIdentifier:12054634] Ensembl:ENSP00000462667 [DatabaseIdentifier:12054635] Ensembl:ENST00000615353 [DatabaseIdentifier:12054636] Ensembl:ENST00000539745 [DatabaseIdentifier:12054637] Ensembl:ENST00000358064 [DatabaseIdentifier:12054638] Ensembl:ENSG00000270882 [DatabaseIdentifier:12054639] Ensembl:ENSG00000277157 [DatabaseIdentifier:12054640] Ensembl:ENSP00000478519 [DatabaseIdentifier:12054641] Ensembl:ENST00000355057 [DatabaseIdentifier:12054642] Ensembl:ENST00000613412 [DatabaseIdentifier:12054643] Ensembl:ENST00000377745 [DatabaseIdentifier:12054644] Ensembl:ENST00000579512 [DatabaseIdentifier:12054645] Ensembl:ENST00000618305 [DatabaseIdentifier:12054646] Ensembl:ENSP00000482412 [DatabaseIdentifier:12054647] Ensembl:ENSP00000489319 [DatabaseIdentifier:12054648] Ensembl:ENSP00000481486 [DatabaseIdentifier:12054649] Ensembl:ENST00000614272 [DatabaseIdentifier:12054650] Ensembl:ENST00000615164 [DatabaseIdentifier:12054651] Ensembl:ENST00000618193 [DatabaseIdentifier:12054652] Ensembl:ENSG00000197061
databaseName	UniProt
dbId	355449
description	recommendedName: Histone H4
displayName	UniProt:P62805 H4C1
geneName	H4C1 H4/A H4FA HIST1H4A H4C2 H4/I H4FI HIST1H4B H4C3 H4/G H4FG HIST1H4C H4C4 H4/B H4FB HIST1H4D H4C5 H4/J H4FJ HIST1H4E H4C6 H4/C H4FC HIST1H4F H4C8 H4/H H4FH HIST1H4H H4C9 H4/M H4FM HIST1H4I H4C11 H4/E H4FE HIST1H4J H4C12 H4/D H4FD HIST1H4K H4C13 H4/K H4FK HIST1H4L H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A H4C15 H4/O H4FO HIST2H4B H4C16 H4-16 HIST4H4
identifier	P62805
isSequenceChanged	false
keyword	3D-structure Acetylation Chromosomal rearrangement Chromosome Citrullination Direct protein sequencing Disease variant DNA-binding Hydroxylation Intellectual disability Isopeptide bond Methylation Nucleosome core Nucleus Phosphoprotein Reference proteome Ubl conjugation
modified	[InstanceEdit:11936968] Wright, Adam, 2024-03-11
name	H4C1
otherIdentifier	11715116_s_at 11726245_s_at 11726246_x_at 11728049_s_at 11733368_at 11733369_x_at 11735753_at 11735775_at 11735776_x_at 11735942_at 11737314_at 11738060_s_at 11738103_at 11738601_at 11741794_s_at 11742669_s_at 11759221_at 121504 152_f_at 16670377 16692626 16761778 17005560 17005868 17016360 17016383 17016406 17016494 17016506 205967_PM_at 205967_at 206951_PM_at 206951_at 207046_PM_at 207046_at 208046_PM_at 208046_at 208076_at 208180_PM_s_at 208180_s_at 208580_PM_x_at 208580_x_at 214463_PM_x_at 214463_x_at 214516_PM_at 214516_at 214562_PM_at 214562_at 232035_PM_at 232035_at 2357896 2357897 2357898 2357899 2357900 2357901 2357902 2357903 2357904 2357906 2357910 2434056 2434103 2434104 2434105 2434106 2434107 2434108 2434109 2434110 2434111 2434116 2899096 2899097 2899147 2899148 2899149 2899218 2899219 2899244 2899245 2899246 2899247 2899248 2899770 2899771 2900064 2900065 2946210 2946211 2946212 2946213 2946320 2946321 2946377 2946379 2946380 2946382 2946384 2946387 2946388 2946389 2947057 2947058 2947082 2947083 2947084 31521_f_at 31751_f_at 33049_at 34027_f_at 3445648 3445649 3445654 3445655 3445656 3445661 39969_at 50025_at 554313 57785_at 59154_at 762_f_at 7905067 7919627 7961483 8117334 8117368 8117402 8117422 8117537 8117598 8124385 8124413 8124448 8124521 8124534 8180255 8180321 82468_at 8294 8359 8360 8361 8362 8363 8364 8365 8366 8367 8368 8370 ADDON000875.hg ADDON001483.hg ADDON002748.hg ADDON002749.hg ADDON002750.hg ADDON002752.hg ADDON002753.hg ADDON002754.hg ADDON002776.hg ADDON002784.hg ADDON002794.hg ADDON002882.hg A_14_P107645 A_14_P121153 A_14_P137590 A_21_P0014172 A_23_P214487 A_23_P30805 A_23_P30813 A_23_P323685 A_23_P359540 A_23_P388871 A_23_P395374 A_23_P415411 A_23_P431179 A_23_P436281 A_23_P70480 A_24_P166407 A_24_P20873 A_24_P261691 A_33_P3299865 A_33_P3344229 A_33_P3351851 A_33_P3410836 GE499003 GE501244 GE502647 GE506852 GE508495 GE572531 GE57844 GE58304 GE59861 GE79334 GE81299 GE81300 GE86856 GO:0000781 GO:0000786 GO:0002376 GO:0003677 GO:0003723 GO:0005198 GO:0005515 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005694 GO:0006325 GO:0006334 GO:0016020 GO:0030154 GO:0030527 GO:0032200 GO:0032991 GO:0043226 GO:0043505 GO:0045653 GO:0046982 GO:0048856 GO:0061644 GO:0065003 GO:0070062 HMNXSV003000546 HMNXSV003001014 HMNXSV003002656 HMNXSV003005824 HMNXSV003015566 HMNXSV003016171 HMNXSV003017340 HMNXSV003023270 HMNXSV003027409 HMNXSV003037762 HMNXSV003046538 HMNXSV003054339 HMNXSV003057871 Hs.131957.0.S1_3p_at Hs.143080.0.S1_3p_at Hs.93758.1.S1_3p_at Hs.93758.1.S1_3p_x_at ILMN_1662359 ILMN_1670033 ILMN_1676580 ILMN_1681542 ILMN_1713436 ILMN_1723111 ILMN_1751120 ILMN_1782329 ILMN_2053992 ILMN_2075334 ILMN_2115340 ILMN_2119320 ILMN_2165369 ILMN_2224990 M16707_rna1_at M16707_rna1_s_at PH_hs_0007863 PH_hs_0012922 PH_hs_0013176 PH_hs_0013177 PH_hs_0017043 PH_hs_0027130 PH_hs_0028888 PH_hs_0029036 PH_hs_0029514 PH_hs_0031203 PH_hs_0031792 PH_hs_0032299 PH_hs_0032446 PH_hs_0033270 PH_hs_0034759 PH_hs_0034804 TC01001173.hg TC01003192.hg TC06000163.hg TC06000166.hg TC06000172.hg TC06000175.hg TC06000266.hg TC06001341.hg TC06001348.hg TC06001355.hg TC06001424.hg TC06001428.hg TC06002644.hg TC12001272.hg X00038_at X60486_at X60487_at Z80787_at g11415029_3p_x_at g4504322_3p_at g5579462_3p_at g5579465_3p_at g5579466_3p_a_at g5579467_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-4570531] polySUMO3-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4570518] monoSUMO1-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-427390] 4xAcK-HIST1H4A [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-212078] AcK5,12-HIST1H4A [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4568744] AcK13-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5229015] Me2aR4-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4754243] Me2sR4-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4754240] MeR4-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5651656] Me3K21-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-977569] HIST1H4A [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-427469] AcK17-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4568748] AcK6-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4568758] AcK9-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5423110] MeK21-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3451124] AcK-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5651652] Me2K21-HIST1H4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-181902] HIST1H4 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999533] ENSEMBL:ENSG00000278637 HIST1H4A [ReferenceDNASequence:8999534] ENSEMBL:ENSG00000270276 HIST1H4A [ReferenceDNASequence:8999535] ENSEMBL:ENSG00000277157 HIST1H4A [ReferenceDNASequence:8999536] ENSEMBL:ENSG00000158406 HIST1H4A [ReferenceDNASequence:8999537] ENSEMBL:ENSG00000278705 HIST1H4A [ReferenceDNASequence:8999538] ENSEMBL:ENSG00000276966 HIST1H4A [ReferenceDNASequence:8999539] ENSEMBL:ENSG00000276180 HIST1H4A [ReferenceDNASequence:8999540] ENSEMBL:ENSG00000275126 HIST1H4A [ReferenceDNASequence:8999541] ENSEMBL:ENSG00000197238 HIST1H4A [ReferenceDNASequence:8999542] ENSEMBL:ENSG00000270882 HIST1H4A [ReferenceDNASequence:8999543] ENSEMBL:ENSG00000274618 HIST1H4A [ReferenceDNASequence:8999544] ENSEMBL:ENSG00000197837 HIST1H4A [ReferenceDNASequence:8999545] ENSEMBL:ENSG00000273542 HIST1H4A [ReferenceDNASequence:8999546] ENSEMBL:ENSG00000197061 HIST1H4A [ReferenceDNASequence:11027374] KEGG Gene (Homo sapiens):121504 H4C1 [ReferenceDNASequence:11027379] KEGG Gene (Homo sapiens):554313 H4C1 [ReferenceDNASequence:11027384] KEGG Gene (Homo sapiens):8294 H4C1 [ReferenceDNASequence:11027389] KEGG Gene (Homo sapiens):8359 H4C1 [ReferenceDNASequence:11027395] KEGG Gene (Homo sapiens):8360 H4C1 [ReferenceDNASequence:11027400] KEGG Gene (Homo sapiens):8361 H4C1 [ReferenceDNASequence:11027408] KEGG Gene (Homo sapiens):8362 H4C1 [ReferenceDNASequence:11027411] KEGG Gene (Homo sapiens):8363 H4C1 [ReferenceDNASequence:11027418] KEGG Gene (Homo sapiens):8364 H4C1 [ReferenceDNASequence:11027423] KEGG Gene (Homo sapiens):8365 H4C1 [ReferenceDNASequence:11027428] KEGG Gene (Homo sapiens):8366 H4C1 [ReferenceDNASequence:11027434] KEGG Gene (Homo sapiens):8367 H4C1 [ReferenceDNASequence:11027438] KEGG Gene (Homo sapiens):8368 H4C1 [ReferenceDNASequence:11027464] KEGG Gene (Homo sapiens):8370 H4C1 [ReferenceDNASequence:11267637] NCBI Gene:121504 H4C1 [ReferenceDNASequence:11267638] BioGPS Gene:121504 H4C1 [ReferenceDNASequence:11267639] CTD Gene:121504 H4C1 [ReferenceDNASequence:11267640] dbSNP Gene:121504 H4C1 [ReferenceDNASequence:11267641] Monarch:121504 H4C1 [ReferenceDNASequence:11267677] NCBI Gene:554313 H4C1 [ReferenceDNASequence:11267678] BioGPS Gene:554313 H4C1 [ReferenceDNASequence:11267679] CTD Gene:554313 H4C1 [ReferenceDNASequence:11267680] dbSNP Gene:554313 H4C1 [ReferenceDNASequence:11267681] Monarch:554313 H4C1 [ReferenceDNASequence:11267697] NCBI Gene:8294 H4C1 [ReferenceDNASequence:11267698] BioGPS Gene:8294 H4C1 [ReferenceDNASequence:11267699] CTD Gene:8294 H4C1 [ReferenceDNASequence:11267700] dbSNP Gene:8294 H4C1 [ReferenceDNASequence:11267701] Monarch:8294 H4C1 [ReferenceDNASequence:11267737] NCBI Gene:8359 H4C1 [ReferenceDNASequence:11267738] BioGPS Gene:8359 H4C1 [ReferenceDNASequence:11267739] CTD Gene:8359 H4C1 [ReferenceDNASequence:11267740] dbSNP Gene:8359 H4C1 [ReferenceDNASequence:11267741] Monarch:8359 H4C1 [ReferenceDNASequence:11267757] NCBI Gene:8360 H4C1 [ReferenceDNASequence:11267758] BioGPS Gene:8360 H4C1 [ReferenceDNASequence:11267759] CTD Gene:8360 H4C1 [ReferenceDNASequence:11267760] dbSNP Gene:8360 H4C1 [ReferenceDNASequence:11267761] Monarch:8360 H4C1 [ReferenceDNASequence:11267807] NCBI Gene:8361 H4C1 [ReferenceDNASequence:11267808] BioGPS Gene:8361 H4C1 [ReferenceDNASequence:11267809] CTD Gene:8361 H4C1 [ReferenceDNASequence:11267810] dbSNP Gene:8361 H4C1 [ReferenceDNASequence:11267811] Monarch:8361 H4C1 [ReferenceDNASequence:11267817] NCBI Gene:8362 H4C1 [ReferenceDNASequence:11267818] BioGPS Gene:8362 H4C1 [ReferenceDNASequence:11267819] CTD Gene:8362 H4C1 [ReferenceDNASequence:11267820] dbSNP Gene:8362 H4C1 [ReferenceDNASequence:11267821] Monarch:8362 H4C1 [ReferenceDNASequence:11267877] NCBI Gene:8363 H4C1 [ReferenceDNASequence:11267878] BioGPS Gene:8363 H4C1 [ReferenceDNASequence:11267879] CTD Gene:8363 H4C1 [ReferenceDNASequence:11267880] dbSNP Gene:8363 H4C1 [ReferenceDNASequence:11267881] Monarch:8363 H4C1 [ReferenceDNASequence:11267887] NCBI Gene:8364 H4C1 [ReferenceDNASequence:11267888] BioGPS Gene:8364 H4C1 [ReferenceDNASequence:11267889] CTD Gene:8364 H4C1 [ReferenceDNASequence:11267890] dbSNP Gene:8364 H4C1 [ReferenceDNASequence:11267891] Monarch:8364 H4C1 [ReferenceDNASequence:11267937] NCBI Gene:8365 H4C1 [ReferenceDNASequence:11267938] BioGPS Gene:8365 H4C1 [ReferenceDNASequence:11267939] CTD Gene:8365 H4C1 [ReferenceDNASequence:11267940] dbSNP Gene:8365 H4C1 [ReferenceDNASequence:11267941] Monarch:8365 H4C1 [ReferenceDNASequence:11267947] NCBI Gene:8366 H4C1 [ReferenceDNASequence:11267948] BioGPS Gene:8366 H4C1 [ReferenceDNASequence:11267949] CTD Gene:8366 H4C1 [ReferenceDNASequence:11267950] dbSNP Gene:8366 H4C1 [ReferenceDNASequence:11267951] Monarch:8366 H4C1 [ReferenceDNASequence:11267997] NCBI Gene:8367 H4C1 [ReferenceDNASequence:11267998] BioGPS Gene:8367 H4C1 [ReferenceDNASequence:11267999] CTD Gene:8367 H4C1 [ReferenceDNASequence:11268000] dbSNP Gene:8367 H4C1 [ReferenceDNASequence:11268001] Monarch:8367 H4C1 [ReferenceDNASequence:11268002] NCBI Gene:8368 H4C1 [ReferenceDNASequence:11268003] BioGPS Gene:8368 H4C1 [ReferenceDNASequence:11268004] CTD Gene:8368 H4C1 [ReferenceDNASequence:11268005] dbSNP Gene:8368 H4C1 [ReferenceDNASequence:11268006] Monarch:8368 H4C1 [ReferenceDNASequence:11268012] NCBI Gene:8370 H4C1 [ReferenceDNASequence:11268013] BioGPS Gene:8370 H4C1 [ReferenceDNASequence:11268014] CTD Gene:8370 H4C1 [ReferenceDNASequence:11268015] dbSNP Gene:8370 H4C1 [ReferenceDNASequence:11268016] Monarch:8370 H4C1 [ReferenceDNASequence:11350799] ENSEMBL_homo_sapiens_GENE:ENSG00000274618.2 H4C1 [ReferenceDNASequence:11350811] ENSEMBL_homo_sapiens_GENE:ENSG00000197238.5 H4C1 [ReferenceDNASequence:11350813] ENSEMBL_homo_sapiens_GENE:ENSG00000197837.4 H4C1 [ReferenceDNASequence:11350825] ENSEMBL_homo_sapiens_GENE:ENSG00000158406.6 H4C1 [ReferenceDNASequence:11350827] ENSEMBL_homo_sapiens_GENE:ENSG00000278705.3 H4C1 [ReferenceDNASequence:11350839] ENSEMBL_homo_sapiens_GENE:ENSG00000197061.5 H4C1 [ReferenceDNASequence:11350841] ENSEMBL_homo_sapiens_GENE:ENSG00000270882.3 H4C1 [ReferenceDNASequence:11350852] ENSEMBL_homo_sapiens_GENE:ENSG00000270276.3 H4C1 [ReferenceDNASequence:11350854] ENSEMBL_homo_sapiens_GENE:ENSG00000273542.2 H4C1 [ReferenceDNASequence:11350863] ENSEMBL_homo_sapiens_GENE:ENSG00000277157.2 H4C1 [ReferenceDNASequence:11350865] ENSEMBL_homo_sapiens_GENE:ENSG00000276966.3 H4C1 [ReferenceDNASequence:11350875] ENSEMBL_homo_sapiens_GENE:ENSG00000276180.2 H4C1 [ReferenceDNASequence:11350877] ENSEMBL_homo_sapiens_GENE:ENSG00000278637.2 H4C1 [ReferenceDNASequence:11350887] ENSEMBL_homo_sapiens_GENE:ENSG00000275126.2 H4C1 [ReferenceDNASequence:11517545] UCSC:P62805 H4C1 [ReferenceDNASequence:11802312] OMIM:142750 H4C1 [ReferenceDNASequence:11802313] OMIM:602822 H4C1 [ReferenceDNASequence:11802319] OMIM:602823 H4C1 [ReferenceDNASequence:11802324] OMIM:602824 H4C1 [ReferenceDNASequence:11802332] OMIM:602825 H4C1 [ReferenceDNASequence:11802335] OMIM:602826 H4C1 [ReferenceDNASequence:11802343] OMIM:602827 H4C1 [ReferenceDNASequence:11802350] OMIM:602828 H4C1 [ReferenceDNASequence:11802358] OMIM:602829 H4C1 [ReferenceDNASequence:11802361] OMIM:602830 H4C1 [ReferenceDNASequence:11802370] OMIM:602831 H4C1 [ReferenceDNASequence:11802374] OMIM:602833 H4C1 [ReferenceDNASequence:11802382] OMIM:615069 H4C1 [ReferenceDNASequence:11873843] HGNC:4781 H4C1 [ReferenceDNASequence:11873844] HGNC:4789 H4C1 [ReferenceDNASequence:11873845] HGNC:4787 H4C1 [ReferenceDNASequence:11873846] HGNC:4782 H4C1 [ReferenceDNASequence:11873847] HGNC:4790 H4C1 [ReferenceDNASequence:11873848] HGNC:4783 H4C1 [ReferenceDNASequence:11873849] HGNC:4788 H4C1 [ReferenceDNASequence:11873850] HGNC:4793 H4C1 [ReferenceDNASequence:11873851] HGNC:4785 H4C1 [ReferenceDNASequence:11873852] HGNC:4784 H4C1 [ReferenceDNASequence:11873853] HGNC:4791 H4C1 [ReferenceDNASequence:11873854] HGNC:4794 H4C1 [ReferenceDNASequence:11873855] HGNC:29607 H4C1 [ReferenceDNASequence:11873856] HGNC:20510 H4C1
referenceTranscript	[ReferenceRNASequence:11455320] RefSeq:NM_001034077.4 H4C1 [ReferenceRNASequence:11455334] RefSeq:NM_003495.2 H4C1 [ReferenceRNASequence:11455346] RefSeq:NM_003538.3 H4C1 [ReferenceRNASequence:11455347] RefSeq:NM_003539.3 H4C1 [ReferenceRNASequence:11455358] RefSeq:NM_003540.3 H4C1 [ReferenceRNASequence:11455359] RefSeq:NM_003541.2 H4C1 [ReferenceRNASequence:11455371] RefSeq:NM_003542.3 H4C1 [ReferenceRNASequence:11455372] RefSeq:NM_003543.3 H4C1 [ReferenceRNASequence:11455387] RefSeq:NM_003544.2 H4C1 [ReferenceRNASequence:11455399] RefSeq:NM_003545.3 H4C1 [ReferenceRNASequence:11455400] RefSeq:NM_003546.2 H4C1 [ReferenceRNASequence:11455413] RefSeq:NM_003548.2 H4C1 [ReferenceRNASequence:11455425] RefSeq:NM_021968.3 H4C1 [ReferenceRNASequence:11455437] RefSeq:NM_175054.2 H4C1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	H4_HUMAN A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7
sequenceLength	103
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P62805

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-4570531] polySUMO3-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4570518] monoSUMO1-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-427390] 4xAcK-HIST1H4A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212078] AcK5,12-HIST1H4A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4568744] AcK13-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5229015] Me2aR4-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4754243] Me2sR4-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4754240] MeR4-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5651656] Me3K21-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-977569] HIST1H4A [extracellular region] [EntityWithAccessionedSequence:R-HSA-427469] AcK17-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4568748] AcK6-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4568758] AcK9-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5423110] MeK21-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3451124] AcK-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5651652] Me2K21-HIST1H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-181902] HIST1H4 [nucleoplasm]
(referenceSequence)	[GroupModifiedResidue:4570560] sumoylated lysine (polySUMO3 [nucleoplasm]) at unknown position [GroupModifiedResidue:4570552] sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position [ModifiedResidue:212043] N6-acetyl-L-lysine at 13 [ModifiedResidue:5229012] asymmetric dimethyl-L-arginine at 4 [ModifiedResidue:4754235] symmetric dimethyl-L-arginine at 4 [ModifiedResidue:4754241] omega-N-methyl-L-arginine at 4 [ModifiedResidue:5651640] N6,N6,N6-trimethyl-L-lysine at 21 [ModifiedResidue:427455] N6-acetyl-L-lysine at 17 [ModifiedResidue:212112] N6-acetyl-L-lysine at 6 [ModifiedResidue:427333] N6-acetyl-L-lysine at 9 [ModifiedResidue:2172673] N6-methyl-L-lysine at 21 [ModifiedResidue:3451125] N6-acetyl-L-lysine at unknown position [ModifiedResidue:5651658] N6,N6-dimethyl-L-lysine at 21
(interactor)	[UndirectedInteraction:12221121] UniProt:P62805 <-> UniProt:Q9UHJ3 (IntAct) [UndirectedInteraction:12221117] UniProt:P62805 <-> UniProt:P0DTC4 (IntAct) [UndirectedInteraction:12221115] UniProt:P62805 <-> UniProt:P13569 (IntAct) [UndirectedInteraction:12221113] UniProt:P62805 <-> UniProt:C4QZQ7 (IntAct) [UndirectedInteraction:12221109] UniProt:P62805 <-> UniProt:P33992 (IntAct) [UndirectedInteraction:12221107] UniProt:P62805 <-> UniProt:Q09028 (IntAct) [UndirectedInteraction:12221105] UniProt:P62805 <-> UniProt:P25205 (IntAct) [UndirectedInteraction:12221103] UniProt:P62805 <-> UniProt:Q9NQ92 (IntAct) [UndirectedInteraction:12221101] UniProt:P62805 <-> UniProt:P33993 (IntAct) [UndirectedInteraction:12221099] UniProt:P62805 <-> UniProt:Q92731 (IntAct) [UndirectedInteraction:12221097] UniProt:P62805 <-> UniProt:P33991 (IntAct) [UndirectedInteraction:12221095] UniProt:P62805 <-> UniProt:Q9UER7-1 (IntAct) [UndirectedInteraction:12221091] UniProt:P62805 <-> UniProt:Q13112 (IntAct) [UndirectedInteraction:12221089] UniProt:P62805 <-> UniProt:P83916 (IntAct) [UndirectedInteraction:12221087] UniProt:P62805 <-> UniProt:Q14684-1 (IntAct) [UndirectedInteraction:12221083] UniProt:P62805 <-> UniProt:O60264 (IntAct) [UndirectedInteraction:12221081] UniProt:P62805 <-> UniProt:Q05BQ5 (IntAct) [UndirectedInteraction:12221079] UniProt:P62805 <-> UniProt:P35609 (IntAct) [UndirectedInteraction:12221077] UniProt:P62805 <-> UniProt:P42858 (IntAct) [UndirectedInteraction:12221075] UniProt:P62805 <-> UniProt:P17252 (IntAct) [UndirectedInteraction:12221073] UniProt:P62805 <-> UniProt:Q8TAP4-4 (IntAct) [UndirectedInteraction:12221071] UniProt:P62805 <-> UniProt:P61981 (IntAct) [UndirectedInteraction:12221069] UniProt:P62805 <-> UniProt:Q15047-2 (IntAct) [UndirectedInteraction:12221067] UniProt:P62805 <-> UniProt:Q8IUQ4 (IntAct) [UndirectedInteraction:12221065] UniProt:P62805 <-> UniProt:Q86UY6-1 (IntAct) [UndirectedInteraction:12221061] UniProt:P62805 <-> UniProt:P55201 (IntAct) [UndirectedInteraction:12221059] UniProt:P62805 <-> UniProt:A8MW92 (IntAct) [UndirectedInteraction:12221057] UniProt:P62805 <-> UniProt:Q9VK33 (IntAct) [UndirectedInteraction:12221055] UniProt:P62805 <-> UniProt:P49450-1 (IntAct) [UndirectedInteraction:12221051] UniProt:P62805 <-> IntAct:EBI-9077146 (IntAct) [UndirectedInteraction:12221047] UniProt:P62805 <-> UniProt:P25440 (IntAct) [UndirectedInteraction:12221045] UniProt:P62805 <-> UniProt:P63104 (IntAct) [UndirectedInteraction:12221043] UniProt:P62805 <-> UniProt:Q8NCD3 (IntAct) [UndirectedInteraction:12221041] UniProt:P62805 <-> UniProt:Q9BVI0 (IntAct) [UndirectedInteraction:12221039] UniProt:P62805 <-> UniProt:Q582G4 (IntAct) [UndirectedInteraction:12221035] UniProt:P62805 <-> UniProt:Q92793 (IntAct) [UndirectedInteraction:12221033] UniProt:P62805 <-> UniProt:Q99873 (IntAct) [UndirectedInteraction:12221031] UniProt:P62805 <-> UniProt:Q15672 (IntAct) [UndirectedInteraction:12221029] UniProt:P62805 <-> UniProt:Q9Y468 (IntAct) [UndirectedInteraction:12221027] UniProt:P62805 <-> UniProt:P45973 (IntAct) [UndirectedInteraction:12221025] UniProt:P62805 <-> UniProt:Q9NVP2 (IntAct) [UndirectedInteraction:12221023] UniProt:P62805 <-> UniProt:Q12830-4 (IntAct) [UndirectedInteraction:12221019] UniProt:P62805 <-> UniProt:Q16695 (IntAct) [UndirectedInteraction:12221017] UniProt:P62805 <-> UniProt:Q92993 (IntAct) [UndirectedInteraction:12221015] UniProt:P62805 <-> UniProt:Q13547 (IntAct) [UndirectedInteraction:12221013] UniProt:P62805 <-> UniProt:O14929 (IntAct) [UndirectedInteraction:12221011] UniProt:P62805 <-> UniProt:Q71DI3 (IntAct) [UndirectedInteraction:12221009] UniProt:P62805 <-> UniProt:Q12888-1 (IntAct) [UndirectedInteraction:12221005] UniProt:P62805 <-> IntAct:EBI-10097414 (IntAct) [UndirectedInteraction:12221001] UniProt:P62805 <-> UniProt:O60885-1 (IntAct) [UndirectedInteraction:12220997] UniProt:P62805 <-> UniProt:O75164 (IntAct) [UndirectedInteraction:12220995] UniProt:P62805 <-> UniProt:P49736 (IntAct) [UndirectedInteraction:12220993] UniProt:P62805 <-> UniProt:Q9NQR1 (IntAct) [UndirectedInteraction:12220991] UniProt:P62805 <-> UniProt:P49450 (IntAct) [UndirectedInteraction:12220989] UniProt:P62805 <-> UniProt:P16104 (IntAct) [UndirectedInteraction:12220987] UniProt:P62805 <-> UniProt:P04908 (IntAct) [UndirectedInteraction:12220985] UniProt:P62805 <-> UniProt:P84243 (IntAct) [UndirectedInteraction:12220983] UniProt:P62805 <-> UniProt:Q12888 (IntAct) [UndirectedInteraction:12220981] UniProt:P62805 <-> UniProt:P68431 (IntAct) [UndirectedInteraction:12220979] UniProt:P62805 <-> UniProt:Q9Y294 (IntAct) [UndirectedInteraction:12212513] UniProt:Q14566 <-> UniProt:P62805 (IntAct) [UndirectedInteraction:12209937] UniProt:O14744 <-> UniProt:P62805 (IntAct) [UndirectedInteraction:12206509] UniProt:Q16576 <-> UniProt:P62805 (IntAct) [UndirectedInteraction:12202033] UniProt:Q9UER7 <-> UniProt:P62805 (IntAct) [UndirectedInteraction:12201755] UniProt:P62993 <-> UniProt:P62805 (IntAct) [UndirectedInteraction:12199753] UniProt:Q13185 <-> UniProt:P62805 (IntAct)

Cite Us!