WLS endocytosis is a clathrin-dependent process. In Drosop...

created [InstanceEdit:3247769] Rothfels, K, 2013-04-05
dbId 3247768
displayName WLS endocytosis is a clathrin-dependent process. In Drosop...
schemaClass Summation
text WLS endocytosis is a clathrin-dependent process. In Drosophila cells, internalization of WLS has been shown to depend on clathrin, AP-2, dynamin, Rab5 and HRS (Belenkaya et al, 2006; Port et al, 2008), while in HeLa cells, WLS colocalizes with endogenous AP-2, and depletion of AP-2 increases WLS levels at the cell surface (Yang et al, 2008). A recent study identified a conserved YEGL endocytosis motif in the third intracellular loop of WLS that is required for its clathrin- and dynamin-dependent internalization (Gasnereau et al, 2011).
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