UniProt:Q08AM6 VAC14

chain
  • chain:1-782
checksum B39AC1F4D619570F
comment
  • FUNCTION Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.SUBUNIT Forms pentamers (PubMed:33098764, PubMed:18950639). Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities (PubMed:17556371, PubMed:18950639, PubMed:33098764). Interacts with NOS1 (PubMed:17161399).SUBUNIT (Microbial infection) Interacts with HTLV-1 Tax.INTERACTION Mainly associated with membranes of the late endocytic pathway.ALTERNATIVE PRODUCTS Ubiquitously expressed.DOMAIN The C-terminal domain (residues 523-782) mediates pentameric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the VAC14 family.SEQUENCE CAUTION Unknown C-terminal region.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 254048
description
  • recommendedName: Protein VAC14 homolog alternativeName: Tax1-binding protein 2
displayName UniProt:Q08AM6 VAC14
geneName
  • VAC14
  • TAX1BP2
  • TRX
identifier Q08AM6
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Disease variant
  • Endoplasmic reticulum
  • Endosome
  • Host-virus interaction
  • Membrane
  • Microsome
  • Neurodegeneration
  • Phosphoprotein
  • Reference proteome
  • Repeat
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • VAC14
otherIdentifier
  • 11719751_a_at
  • 11719752_x_at
  • 11750690_a_at
  • 16827850
  • 218169_PM_at
  • 218169_at
  • 3697219
  • 3697220
  • 3697226
  • 3697227
  • 3697231
  • 3697233
  • 3697234
  • 3697235
  • 3697236
  • 3697261
  • 3697266
  • 3697275
  • 3697276
  • 3697277
  • 3697283
  • 3697284
  • 3697294
  • 3697295
  • 3697296
  • 3697297
  • 3697298
  • 3697299
  • 3697300
  • 3697301
  • 3697302
  • 3697311
  • 3697312
  • 55697
  • 64468_at
  • 8002421
  • A_23_P77590
  • GE55709
  • GE86666
  • GE86794
  • GO:0000139
  • GO:0005515
  • GO:0005768
  • GO:0005773
  • GO:0005783
  • GO:0005794
  • GO:0005829
  • GO:0006629
  • GO:0006661
  • GO:0007165
  • GO:0010008
  • GO:0016020
  • GO:0016192
  • GO:0023052
  • GO:0031410
  • GO:0031901
  • GO:0031902
  • GO:0038023
  • GO:0042802
  • GO:0043226
  • GO:0043231
  • GO:0060089
  • GO:0070772
  • GO:0098830
  • GO:0099149
  • HMNXSV003013007
  • HMNXSV003013912
  • ILMN_1750792
  • ILMN_1776092
  • ILMN_1799024
  • PH_hs_0026022
  • TC16001240.hg
  • g8922339_3p_at
  • g8922339_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VAC14_HUMAN
  • B3KPJ5
  • B3KSM8
  • Q13174
  • Q6IA12
  • Q7L4Y1
  • Q9BW96
  • Q9H6V6
sequenceLength 782
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q08AM6

Referrals

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