UniProt:Q9H295 DCSTAMP

chain
  • chain:1-470
checksum EA2B858FD2C7560C
comment
  • FUNCTION Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.SUBUNIT Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail) (By similarity). Interacts with CREB3.INTERACTION Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity).ALTERNATIVE PRODUCTS Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.DEVELOPMENTAL STAGE Constitutively expressed in dendritic cells from day 3-8 in culture.INDUCTION Expression is down-regulated by dexamethasone and up-regulated by IL4/interleukin-4 in macrophages. Down-regulated in CD40L-activated dendritic cells.DOMAIN Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).PTM Glycosylated.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 251809
description
  • recommendedName: Dendritic cell-specific transmembrane protein shortName: DC-STAMP shortName: hDC-STAMP alternativeName: Dendrocyte-expressed seven transmembrane protein alternativeName: IL-four-induced protein shortName: FIND alternativeName: Transmembrane 7 superfamily member 4
displayName UniProt:Q9H295 DCSTAMP
geneName
  • DCSTAMP
  • TM7SF4
identifier Q9H295
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Differentiation
  • Endoplasmic reticulum
  • Endosome
  • Immunity
  • Membrane
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • DCSTAMP
otherIdentifier
  • 11736524_at
  • 11753365_a_at
  • 17071722
  • 221266_PM_s_at
  • 221266_s_at
  • 3110609
  • 3110610
  • 3110611
  • 3110620
  • 3110621
  • 3110625
  • 3110626
  • 3110627
  • 8147830
  • 81501
  • A_23_P43107
  • GO:0002376
  • GO:0005515
  • GO:0005768
  • GO:0005783
  • GO:0005789
  • GO:0005886
  • GO:0009986
  • GO:0010008
  • GO:0016020
  • GO:0030154
  • GO:0030308
  • GO:0030316
  • GO:0031410
  • GO:0033116
  • GO:0034241
  • GO:0036006
  • GO:0043011
  • GO:0043226
  • GO:0045657
  • GO:0045780
  • GO:0061024
  • GO:0061025
  • GO:0071353
  • GO:0071356
  • GO:0072675
  • HMNXSV003041320
  • ILMN_1793730
  • PH_hs_0012255
  • TC08000653.hg
  • g13540564_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DCSTP_HUMAN
  • B7ZVW2
  • E7ESG0
  • Q2M2D5
sequenceLength 470
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q9H295
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