UniProt:Q9Y6R1 SLC4A4

chain
  • chain:1-1079
checksum 14B981A94DD64293
comment
  • FUNCTION Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.ACTIVITY REGULATION Inhibited by stilbene derivatives and regulated by cyclic AMP.SUBUNIT Homodimer (PubMed:29500354). Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity (PubMed:12411514, PubMed:14567693, PubMed:15218065, PubMed:15563508). Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890). Interacts with AHCYL2 (By similarity).TISSUE SPECIFICITY Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.PTM Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity.PTM N-glycosylation is not necessary for the transporter basic functions.DISEASE Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17).SIMILARITY Belongs to the anion exchanger (TC 2.A.31) family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 247288
description
  • recommendedName: Electrogenic sodium bicarbonate cotransporter 1 shortName:Sodium bicarbonate cotransporter alternativeName: Na(+)/HCO3(-) cotransporter alternativeName: Solute carrier family 4 member 4 alternativeName: kNBC1
displayName UniProt:Q9Y6R1 SLC4A4
geneName
  • SLC4A4
  • NBC
  • NBC1
  • NBCE1
identifier Q9Y6R1
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Ion transport
  • Membrane
  • Phosphoprotein
  • Reference proteome
  • Retinitis pigmentosa
  • Sodium
  • Sodium transport
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • SLC4A4
otherIdentifier
  • 0001580463
  • 11717820_a_at
  • 11717821_a_at
  • 11717822_a_at
  • 11742188_a_at
  • 11763519_a_at
  • 1554027_a_at
  • 16967631
  • 203908_at
  • 210738_s_at
  • 210739_x_at
  • 211494_s_at
  • 2730739
  • 2730751
  • 2730752
  • 2730760
  • 2730768
  • 2730769
  • 2730780
  • 2730781
  • 2730782
  • 2730783
  • 2730784
  • 2730790
  • 2730792
  • 2730793
  • 2730794
  • 2730795
  • 2730796
  • 2730799
  • 2730800
  • 2730801
  • 2730802
  • 2730803
  • 2730804
  • 2730805
  • 2730806
  • 2730807
  • 2730808
  • 2730810
  • 2730811
  • 2730813
  • 2730814
  • 2730817
  • 2730818
  • 2730819
  • 2730820
  • 2730821
  • 35285_at
  • 35871_s_at
  • 8095585
  • 8671
  • 87069_at
  • A_14_P100967
  • A_14_P103730
  • A_14_P107050
  • A_14_P138558
  • A_23_P22205
  • A_32_P349145
  • A_32_P358887
  • GE54086
  • GO:0003013
  • GO:0003674
  • GO:0005452
  • GO:0005515
  • GO:0005575
  • GO:0005576
  • GO:0005615
  • GO:0005886
  • GO:0005887
  • GO:0005975
  • GO:0006091
  • GO:0006810
  • GO:0006811
  • GO:0006814
  • GO:0006820
  • GO:0008150
  • GO:0008509
  • GO:0008510
  • GO:0009056
  • GO:0009986
  • GO:0015293
  • GO:0015698
  • GO:0015701
  • GO:0016020
  • GO:0016021
  • GO:0016323
  • GO:0022857
  • GO:0034641
  • GO:0035725
  • GO:0036376
  • GO:0042391
  • GO:0042592
  • GO:0042802
  • GO:0043226
  • GO:0044214
  • GO:0044281
  • GO:0045821
  • GO:0050801
  • GO:0051453
  • GO:0055085
  • GO:0070062
  • GO:0098656
  • GO:0150104
  • HMNXSV003017848
  • Hs2.5462.2.A1_3p_a_at
  • Hs2.5462.2.A1_3p_s_at
  • ILMN_1734897
  • ILMN_2184556
  • PH_hs_0000563
  • TC04000396.hg
  • g3298567_3p_a_at
  • g4507024_3p_at
  • g8886014_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • S4A4_HUMAN
  • C4B714
  • O15153
  • Q8NEJ2
  • Q9H262
  • Q9NRZ1
  • Q9UIC0
  • Q9UIC1
  • Q9UP50
sequenceLength 1079
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q9Y6R1

Referrals

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