UniProt:Q99942 RNF5

chain
  • initiator methionine:
  • chain:2-180
checksum E5AFA4DE6DE85942
comment
  • FUNCTION Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19285439, PubMed:19269966). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019). Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with PXN (PubMed:12861019). Interacts with Salmonella typhimurium sopA (PubMed:12861019). Interacts with JKAMP (PubMed:19269966). Interacts with STING1; the interaction of endogenous proteins is dependent on viral infection (PubMed:19285439).INTERACTION Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.TISSUE SPECIFICITY Widely expressed.SIMILARITY Belongs to the RNF5 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 246266
description
  • recommendedName: fullName evidence="16"E3 ubiquitin-protein ligase RNF5 ecNumber evidence="7 8 9"2.3.2.27 alternativeName: fullName evidence="14"RING finger protein 5 alternativeName: fullName evidence="13"Ram1 homolog shortName evidence="13"HsRma1
displayName UniProt:Q99942 RNF5
geneName
  • RNF5
  • G16
  • NG2
  • RMA1
identifier Q99942
isSequenceChanged false
keyword
  • Acetylation
  • Cell membrane
  • Endoplasmic reticulum
  • Membrane
  • Metal-binding
  • Mitochondrion
  • Phosphoprotein
  • Reference proteome
  • Transferase
  • Transmembrane
  • Transmembrane helix
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • RNF5
otherIdentifier
  • 11757623_s_at
  • 17007237
  • 17026393
  • 17028297
  • 17033588
  • 17035866
  • 17038580
  • 17041209
  • 209111_PM_at
  • 209111_at
  • 2903131
  • 2903132
  • 2903133
  • 2903135
  • 2903137
  • 2903139
  • 2903140
  • 2903141
  • 3132181
  • 3132182
  • 3132183
  • 3132184
  • 3132186
  • 3132187
  • 3132188
  • 3132189
  • 3132191
  • 3132192
  • 3132193
  • 3132194
  • 33347_at
  • 6048
  • 8118535
  • 8150356
  • 8178188
  • 8179472
  • A_23_P320200
  • A_23_P8095
  • A_32_P185149
  • GE62145
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005739
  • GO:0005783
  • GO:0005789
  • GO:0005886
  • GO:0006511
  • GO:0006914
  • GO:0008270
  • GO:0009617
  • GO:0010507
  • GO:0016020
  • GO:0016567
  • GO:0016740
  • GO:0030163
  • GO:0030433
  • GO:0031648
  • GO:0031966
  • GO:0036211
  • GO:0036503
  • GO:0042802
  • GO:0043226
  • GO:0044390
  • GO:0044877
  • GO:0046872
  • GO:0055085
  • GO:0061630
  • GO:0070534
  • GO:0070936
  • GO:0071712
  • GO:0140096
  • GO:2000785
  • HMNXSV003008559
  • HMNXSV003047858
  • ILMN_2044927
  • PH_hs_0030665
  • PH_hs_0039561
  • TC06000395.hg
  • TC06002724.hg
  • TC08002294.hg
  • TC6_apd_hap1000044.hg
  • TC6_cox_hap2000087.hg
  • TC6_mann_hap4000071.hg
  • TC6_mcf_hap5000073.hg
  • TC6_qbl_hap6000078.hg
  • TC6_ssto_hap7000073.hg
  • U89336_cds4_at
  • g13278761_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RNF5_HUMAN
  • A2BFI6
  • B2R4K3
  • Q0VDB7
  • Q9UMQ2
sequenceLength 180
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q99942
Cite Us!