UniProt:O75525 KHDRBS3

chain
  • chain:1-346
checksum CA37968A4DF6D573
comment
  • FUNCTION RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation.FUNCTION (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.SUBUNIT Self-associates to form homooligomers; dimerization increases RNA affinity (PubMed:26758068). Interacts with KHDRBS2/SLM-1 (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (PubMed:10332027). Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts with HNRPL (By similarity). Interacts with RBMX, RBMY1A1, p85 subunit of PI3-kinase, SERPINB5 (PubMed:10564820, PubMed:10332027, PubMed:10749975, PubMed:21725612). Interacts with SIAH1 which promotes targeting for degradation (PubMed:15163637).TISSUE SPECIFICITY Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.INDUCTION Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death.DOMAIN The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.PTM Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.SIMILARITY Belongs to the KHDRBS family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 234328
description
  • recommendedName: KH domain-containing, RNA-binding, signal transduction-associated protein 3 alternativeName: RNA-binding protein T-Star alternativeName: Sam68-like mammalian protein 2 shortName:SLM-2 alternativeName: Sam68-like phosphotyrosine protein
displayName UniProt:O75525 KHDRBS3
geneName
  • KHDRBS3
  • SALP
  • SLM2
identifier O75525
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Host-virus interaction
  • Isopeptide bond
  • mRNA processing
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • RNA-binding
  • SH3-binding
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • KHDRBS3
otherIdentifier
  • 0005550452
  • 10656
  • 11732318_a_at
  • 11744581_a_at
  • 17072979
  • 209781_s_at
  • 3117383
  • 3117385
  • 3117386
  • 3117387
  • 3117388
  • 3117399
  • 3117400
  • 3117403
  • 3117404
  • 3117406
  • 3117412
  • 3117420
  • 3117431
  • 3117432
  • 3117433
  • 3117434
  • 3117435
  • 3117436
  • 3117437
  • 31786_at
  • 8148448
  • A_14_P114504
  • A_23_P257335
  • A_33_P3332081
  • A_33_P3394727
  • GE54435
  • GO:0000381
  • GO:0003674
  • GO:0003676
  • GO:0003723
  • GO:0003729
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005634
  • GO:0005654
  • GO:0006397
  • GO:0008150
  • GO:0016032
  • GO:0017124
  • GO:0019904
  • GO:0032991
  • GO:0034641
  • GO:0042802
  • GO:0043226
  • GO:0044403
  • GO:0048024
  • HMNXSV003024155
  • HMNXSV003045031
  • Hs.13565.1.A1_3p_at
  • ILMN_1691747
  • ILMN_1727790
  • PH_hs_0001310
  • TC08000778.hg
  • g3273831_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KHDR3_HUMAN
  • Q6NUL8
  • Q9UPA8
sequenceLength 346
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/O75525

Referrals

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(referenceSequence)
(interactor)
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