Reactome | UniProt:Q5VWX1 KHDRBS2

Schema > ReferenceGeneProduct > Entries

UniProt:Q5VWX1 KHDRBS2 Show undefined attributes

chain	chain:1-349
checksum	EF16E301D8A12164
comment	FUNCTION RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.SUBUNIT Self-associates to form homooligomers (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (By similarity). Interacts with RBMX (PubMed:19282290). Interacts with SAFB, SFRS9 and YTHDC1. Interacts with FYN and PLCG1 (via SH3 domain). Interacts (phosphorylated) with FYN, GRB2, PLCG1 and RASA1 (via SH2 domain) (By similarity).INTERACTION Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.PTM Methylated.PTM Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis (By similarity).SIMILARITY Belongs to the KHDRBS family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:10972401] Pharos - Targets:Q5VWX1 [DatabaseIdentifier:11052960] OpenTargets:ENSG00000112232 [DatabaseIdentifier:11599979] RefSeq:NP_689901.2 [DatabaseIdentifier:11811729] PRO:Q5VWX1 [DatabaseIdentifier:11844260] GeneCards:Q5VWX1 [DatabaseIdentifier:11894508] HPA:ENSG00000112232-KHDRBS2 [DatabaseIdentifier:12006989] Ensembl:ENSP00000281156 [DatabaseIdentifier:12006990] Ensembl:ENST00000281156 [DatabaseIdentifier:12006991] Ensembl:ENSG00000112232
databaseName	UniProt
dbId	234324
description	recommendedName: KH domain-containing, RNA-binding, signal transduction-associated protein 2 alternativeName: Sam68-like mammalian protein 1 shortName: SLM-1 shortName: hSLM-1
displayName	UniProt:Q5VWX1 KHDRBS2
geneName	KHDRBS2 SLM1
identifier	Q5VWX1
isSequenceChanged	false
keyword	Methylation mRNA processing Nucleus Phosphoprotein Reference proteome RNA-binding SH3-binding Transcription Transcription regulation
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	KHDRBS2
otherIdentifier	11735663_at 11747846_s_at 17020499 202559 215527_PM_at 215527_at 2959052 2959053 2959054 2959055 2959059 2959069 2959086 2959087 2959091 2959097 2959104 2959110 2959111 2959112 2959120 32024_at 8127370 A_23_P366453 GO:0000381 GO:0003676 GO:0003723 GO:0003729 GO:0005515 GO:0005634 GO:0005654 GO:0006397 GO:0008143 GO:0008266 GO:0016071 GO:0017124 GO:0042169 GO:0043226 GO:0048024 Hs.226014.0.S1_3p_at PH_hs_0032115 TC06001842.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8849028] KHDRBS2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8849031] p-Y-KHDRBS2 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990793] ENSEMBL:ENSG00000112232 KHDRBS2 [ReferenceDNASequence:11022107] KEGG Gene (Homo sapiens):202559 KHDRBS2 [ReferenceDNASequence:11227048] NCBI Gene:202559 KHDRBS2 [ReferenceDNASequence:11227049] BioGPS Gene:202559 KHDRBS2 [ReferenceDNASequence:11227050] CTD Gene:202559 KHDRBS2 [ReferenceDNASequence:11227051] dbSNP Gene:202559 KHDRBS2 [ReferenceDNASequence:11227052] Monarch:202559 KHDRBS2 [ReferenceDNASequence:11343477] ENSEMBL_homo_sapiens_GENE:ENSG00000112232.10 KHDRBS2 [ReferenceDNASequence:11512924] UCSC:Q5VWX1 KHDRBS2 [ReferenceDNASequence:11793524] OMIM:610487 KHDRBS2 [ReferenceDNASequence:11871614] HGNC:18114 KHDRBS2 [ReferenceDNASequence:12193739] COSMIC (genes):KHDRBS2 KHDRBS2
referenceTranscript	[ReferenceRNASequence:11463650] RefSeq:NM_152688.3 KHDRBS2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	KHDR2_HUMAN A8K7M8 Q8N4I4 Q8TCZ4
sequenceLength	349
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q5VWX1

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8849028] KHDRBS2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8849031] p-Y-KHDRBS2 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:8849043] O4'-phospho-L-tyrosine at unknown position
(interactor)	[UndirectedInteraction:12324631] UniProt:Q5VWX1 <-> UniProt:Q92530 (IntAct) [UndirectedInteraction:12324629] UniProt:Q5VWX1 <-> UniProt:Q01844 (IntAct) [UndirectedInteraction:12324627] UniProt:Q5VWX1 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12324627] UniProt:Q5VWX1 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12324625] UniProt:Q5VWX1 <-> UniProt:Q6VB84 (IntAct) [UndirectedInteraction:12324623] UniProt:Q5VWX1 <-> UniProt:Q03014 (IntAct) [UndirectedInteraction:12324621] UniProt:Q5VWX1 <-> UniProt:P18075 (IntAct) [UndirectedInteraction:12324619] UniProt:Q5VWX1 <-> UniProt:Q9P0T4 (IntAct) [UndirectedInteraction:12324617] UniProt:Q5VWX1 <-> UniProt:Q6ZNH5 (IntAct) [UndirectedInteraction:12324615] UniProt:Q5VWX1 <-> UniProt:P98175 (IntAct) [UndirectedInteraction:12324613] UniProt:Q5VWX1 <-> IntAct:EBI-16428938 (IntAct) [UndirectedInteraction:12324611] UniProt:Q5VWX1 <-> UniProt:Q9Y3Y2-3 (IntAct) [UndirectedInteraction:12324609] UniProt:Q5VWX1 <-> UniProt:O43390 (IntAct) [UndirectedInteraction:12324607] UniProt:Q5VWX1 <-> UniProt:Q96EG3 (IntAct) [UndirectedInteraction:12324605] UniProt:Q5VWX1 <-> UniProt:Q96AH0 (IntAct) [UndirectedInteraction:12324603] UniProt:Q5VWX1 <-> UniProt:Q8WTP8 (IntAct) [UndirectedInteraction:12324601] UniProt:Q5VWX1 <-> UniProt:A0A0S2Z5X4 (IntAct) [UndirectedInteraction:12324599] UniProt:Q5VWX1 <-> IntAct:EBI-10188384 (IntAct) [UndirectedInteraction:12324597] UniProt:Q5VWX1 <-> UniProt:Q8NE01 (IntAct) [UndirectedInteraction:12324595] UniProt:Q5VWX1 <-> UniProt:Q5D0E6-2 (IntAct) [UndirectedInteraction:12324593] UniProt:Q5VWX1 <-> UniProt:Q8TBE0 (IntAct) [UndirectedInteraction:12324591] UniProt:Q5VWX1 <-> UniProt:P38340 (IntAct) [UndirectedInteraction:12324589] UniProt:Q5VWX1 <-> IntAct:EBI-10207182 (IntAct) [UndirectedInteraction:12324585] UniProt:Q5VWX1 <-> UniProt:P36084 (IntAct) [UndirectedInteraction:12324583] UniProt:Q5VWX1 <-> UniProt:Q9UQ90 (IntAct) [UndirectedInteraction:12324581] UniProt:Q5VWX1 <-> UniProt:Q8TBB1 (IntAct) [UndirectedInteraction:12324579] UniProt:Q5VWX1 <-> UniProt:Q8TAI1 (IntAct) [UndirectedInteraction:12324575] UniProt:Q5VWX1 <-> UniProt:G3V1X1 (IntAct) [UndirectedInteraction:12324573] UniProt:Q5VWX1 <-> IntAct:EBI-22318346 (IntAct) [UndirectedInteraction:12324571] UniProt:Q5VWX1 <-> UniProt:Q8IXW0 (IntAct) [UndirectedInteraction:12324569] UniProt:Q5VWX1 <-> UniProt:P40507 (IntAct) [UndirectedInteraction:12217923] UniProt:Q96PK6 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12219047] UniProt:O75525 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12219509] UniProt:O75791 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12225729] UniProt:Q9Y3Y2 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12234563] UniProt:Q13330 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12261351] UniProt:P29597 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12265859] UniProt:Q13882 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12278425] UniProt:O00560 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12293415] UniProt:P0DMM9 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12294255] UniProt:P40938 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12313209] UniProt:Q92608 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:12324549] UniProt:Q5VWX1 <-> UniProt:P38159 (IntAct) [UndirectedInteraction:12324551] UniProt:Q5VWX1 <-> UniProt:P98179 (IntAct) [UndirectedInteraction:12324553] UniProt:Q5VWX1 <-> UniProt:Q8WWY3 (IntAct) [UndirectedInteraction:12324555] UniProt:Q5VWX1 <-> UniProt:Q96MU7 (IntAct) [UndirectedInteraction:12324557] UniProt:Q5VWX1 <-> UniProt:P79522 (IntAct) [UndirectedInteraction:12324559] UniProt:Q5VWX1 <-> UniProt:Q9NQX5 (IntAct) [UndirectedInteraction:12324561] UniProt:Q5VWX1 <-> UniProt:Q8NEC5 (IntAct) [UndirectedInteraction:12324563] UniProt:Q5VWX1 <-> UniProt:P61978-2 (IntAct) [UndirectedInteraction:12324565] UniProt:Q5VWX1 <-> UniProt:Q14011 (IntAct) [UndirectedInteraction:12324567] UniProt:Q5VWX1 <-> UniProt:P02008 (IntAct)

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