UniProt:Q12794 HYAL1

chain
  • signal peptide:1-21
  • chain:22-435
checksum 9C2B2D8DB361E0BB
comment
  • FUNCTION May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.TISSUE SPECIFICITY Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.SIMILARITY Belongs to the glycosyl hydrolase 56 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 232302
description
  • recommendedName: Hyaluronidase-1 shortName:Hyal-1 ecNumber3.2.1.35/ecNumber alternativeName: Hyaluronoglucosaminidase-1 alternativeName: Lung carcinoma protein 1 shortName:LuCa-1
displayName UniProt:Q12794 HYAL1
geneName
  • HYAL1
  • LUCA1
identifier Q12794
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Glycosidase
  • Hydrolase
  • Lysosome
  • Mucopolysaccharidosis
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • HYAL1
otherIdentifier
  • 0001580300
  • 0004760113
  • 0004780162
  • 11740989_a_at
  • 11740990_x_at
  • 11751860_a_at
  • 11751861_x_at
  • 11753209_a_at
  • 11753210_x_at
  • 11755620_a_at
  • 1546_at
  • 16954401
  • 210619_s_at
  • 2675141
  • 2675147
  • 2675149
  • 2675151
  • 2675152
  • 2675153
  • 2675155
  • 2675156
  • 2675157
  • 2675158
  • 2675159
  • 2675160
  • 2675161
  • 2675162
  • 2675163
  • 2675164
  • 2675165
  • 2675166
  • 3373
  • 37176_at
  • 3809823
  • 8087611
  • A_23_P69329
  • A_24_P208774
  • GE58858
  • GO:0000278
  • GO:0000302
  • GO:0003674
  • GO:0003824
  • GO:0004415
  • GO:0005575
  • GO:0005576
  • GO:0005615
  • GO:0005622
  • GO:0005737
  • GO:0005764
  • GO:0005773
  • GO:0005975
  • GO:0006790
  • GO:0006950
  • GO:0006954
  • GO:0007049
  • GO:0007155
  • GO:0008134
  • GO:0008150
  • GO:0008152
  • GO:0008283
  • GO:0009056
  • GO:0009058
  • GO:0009615
  • GO:0009790
  • GO:0010634
  • GO:0016757
  • GO:0016787
  • GO:0016798
  • GO:0022607
  • GO:0030207
  • GO:0030212
  • GO:0030213
  • GO:0030214
  • GO:0030307
  • GO:0030308
  • GO:0031410
  • GO:0036117
  • GO:0036120
  • GO:0040007
  • GO:0040011
  • GO:0043202
  • GO:0043226
  • GO:0044281
  • GO:0044344
  • GO:0044403
  • GO:0045766
  • GO:0045785
  • GO:0045927
  • GO:0046677
  • GO:0046718
  • GO:0048646
  • GO:0048856
  • GO:0048870
  • GO:0050501
  • GO:0050679
  • GO:0051216
  • GO:0060272
  • GO:0070062
  • GO:0071347
  • GO:0071356
  • GO:0071467
  • GO:0071493
  • GO:1900087
  • GO:1900106
  • HMNXSV003049316
  • ILMN_1693230
  • ILMN_1712620
  • ILMN_1739813
  • ILMN_2314417
  • PH_hs_0004350
  • TC03001427.hg
  • U03056_at
  • g5825510_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HYAL1_HUMAN
  • Q6FH23
  • Q6PIZ6
  • Q7KYU2
  • Q7LE34
  • Q8NFK5
  • Q8NFK6
  • Q8NFK7
  • Q8NFK8
  • Q8NFK9
  • Q93013
  • Q9UKD5
  • Q9UNI8
sequenceLength 435
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q12794
Cite Us!