UniProt:Q9NVH1 DNAJC11

chain
  • initiator methionine:
  • chain:2-559
checksum B16D49B296362800
comment
  • FUNCTION Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.SUBUNIT Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both mitochondrial membranes termed the mitochondrial intermembrane space bridging (MIB) complex.INTERACTION Isoforms show differential submitochondrial localization. A 57 kDa form (potentially isoform 3) shows either mitochondrial matrix or innermembrane (IM) localization, possibly anchored to the IM facing the matrix. A 35 kDa form behaved either as an inner membrane space (IMS) or an IM protein exposed to the IMS.SUBCELLULAR LOCATION Additional isoforms seem to exist.SIMILARITY Belongs to the DNAJC11 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 227127
description
  • recommendedName: DnaJ homolog subfamily C member 11
displayName UniProt:Q9NVH1 DNAJC11
geneName
  • DNAJC11
identifier Q9NVH1
isSequenceChanged false
keyword
  • Acetylation
  • Alternative splicing
  • Chaperone
  • Coiled coil
  • Membrane
  • Mitochondrion
  • Mitochondrion outer membrane
  • Phosphoprotein
  • Reference proteome
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • DNAJC11
otherIdentifier
  • 11744749_a_at
  • 11749523_a_at
  • 11754704_a_at
  • 1555360_PM_a_at
  • 1555360_a_at
  • 16681225
  • 215792_PM_s_at
  • 215792_s_at
  • 2394842
  • 2394843
  • 2394844
  • 2394845
  • 2394846
  • 2394847
  • 2394850
  • 2394852
  • 2394855
  • 2394856
  • 2394857
  • 2394858
  • 2394859
  • 2394866
  • 2394868
  • 2394871
  • 2394874
  • 2394877
  • 2394879
  • 2394884
  • 2394885
  • 36840_at
  • 55735
  • 7912112
  • 86585_at
  • A_24_P413735
  • A_33_P3241108
  • GE62281
  • GO:0001401
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005739
  • GO:0005741
  • GO:0007005
  • GO:0007007
  • GO:0016020
  • GO:0016607
  • GO:0042407
  • GO:0043226
  • GO:0061024
  • GO:0061617
  • GO:0140275
  • HMNXSV003017006
  • Hs.261134.1.S1_3p_a_at
  • Hs2.261134.2.S1_3p_s_at
  • ILMN_1747903
  • PH_hs_0013625
  • PH_hs_0033957
  • TC01002156.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DJC11_HUMAN
  • Q4VWF5
  • Q5VZN0
  • Q6PK20
  • Q6PK70
  • Q8NDM2
  • Q96CL7
sequenceLength 559
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q9NVH1
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