UniProt:O75689 ADAP1

chain
  • chain:1-374
checksum 38547281FB09D9B9
comment
  • FUNCTION GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).SUBUNIT Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.INTERACTION Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.ALTERNATIVE PRODUCTS Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.PTM Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 222799
description
  • recommendedName: Arf-GAP with dual PH domain-containing protein 1 alternativeName: Centaurin-alpha-1 shortName: Cnt-a1 alternativeName: Putative MAPK-activating protein PM25
displayName UniProt:O75689 ADAP1
geneName
  • ADAP1
  • CENTA1
identifier O75689
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • GTPase activation
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Zinc
  • Zinc-finger
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • ADAP1
otherIdentifier
  • 11033
  • 11727926_a_at
  • 11746479_a_at
  • 11746480_x_at
  • 11751432_a_at
  • 11751433_x_at
  • 17054276
  • 219150_PM_s_at
  • 219150_s_at
  • 3034988
  • 3034989
  • 3034990
  • 3034991
  • 3034992
  • 3034993
  • 3034994
  • 3034995
  • 3034997
  • 3034998
  • 3035002
  • 3035003
  • 3035013
  • 3035015
  • 3035017
  • 3035020
  • 3035022
  • 3035023
  • 8137680
  • 90265_PM_at
  • 90265_at
  • A_23_P145865
  • A_33_P3422133
  • GE54726
  • GO:0005096
  • GO:0005515
  • GO:0005547
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0007166
  • GO:0008289
  • GO:0023052
  • GO:0043087
  • GO:0043226
  • GO:0043231
  • GO:0043533
  • GO:0043547
  • GO:0046872
  • GO:0098772
  • GO:1902936
  • ILMN_2047511
  • PH_hs_0008158
  • TC07003348.hg
  • g6806912_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ADAP1_HUMAN
  • A4D2Q2
  • B3KRZ4
  • B4DVA6
  • F6XZ68
  • H7C2Q4
sequenceLength 374
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O75689
Cite Us!