Reactome | UniProt:Q9UKI2 CDC42EP3

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UniProt:Q9UKI2 CDC42EP3 Show undefined attributes

chain	chain:1-254
checksum	C31CDBE151C161ED
comment	FUNCTION Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.SUBUNIT Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.INTERACTION Highly expressed in the heart and weakly in the brain.SIMILARITY Belongs to the BORG/CEP family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:10976809] Pharos - Targets:Q9UKI2 [DatabaseIdentifier:11065519] OpenTargets:ENSG00000163171 [DatabaseIdentifier:11625611] RefSeq:NP_001257365.1 [DatabaseIdentifier:11625613] RefSeq:NP_001257366.1 [DatabaseIdentifier:11625615] RefSeq:NP_001257367.1 [DatabaseIdentifier:11625617] RefSeq:NP_006440.2 [DatabaseIdentifier:11625619] RefSeq:XP_011530784.1 [DatabaseIdentifier:11826548] PRO:Q9UKI2 [DatabaseIdentifier:11846857] GeneCards:Q9UKI2 [DatabaseIdentifier:11885623] HMDB Protein:HMDBP08320 [DatabaseIdentifier:11898536] HPA:ENSG00000163171-CDC42EP3 [DatabaseIdentifier:12062331] Ensembl:ENST00000611976 [DatabaseIdentifier:12062332] Ensembl:ENSP00000295324 [DatabaseIdentifier:12062333] Ensembl:ENSP00000480549 [DatabaseIdentifier:12062334] Ensembl:ENSG00000163171 [DatabaseIdentifier:12062335] Ensembl:ENST00000295324
databaseName	UniProt
dbId	220236
description	recommendedName: Cdc42 effector protein 3 alternativeName: Binder of Rho GTPases 2 alternativeName: MSE55-related Cdc42-binding protein
displayName	UniProt:Q9UKI2 CDC42EP3
geneName	CDC42EP3 BORG2 CEP3
identifier	Q9UKI2
isSequenceChanged	false
keyword	Cell shape Cytoplasm Cytoskeleton Membrane Phosphoprotein Reference proteome
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	CDC42EP3
otherIdentifier	10602 11720498_at 11720499_at 209286_PM_at 209286_at 209287_PM_s_at 209287_s_at 209288_PM_s_at 209288_s_at 225685_PM_at 225685_at 2548624 2548625 2548626 2548627 2548628 2548631 33362_at 54063_at 8051573 A_23_P209636 A_24_P924697 A_33_P3331307 GE61803 GO:0005515 GO:0005519 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0007010 GO:0007165 GO:0007266 GO:0008092 GO:0008360 GO:0012505 GO:0015629 GO:0016020 GO:0023052 GO:0030838 GO:0031267 GO:0031274 GO:0043226 GO:0048856 GO:0065003 HMNXSV003031742 Hs.260024.0.A3_3p_at Hs.6774.0.A1_3p_at ILMN_1736327 PH_hs_0017080 TC02001746.hg g4324453_3p_a_at g6807668_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5692659] p-CDC42EP3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5692689] CDC42EP3 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8989989] ENSEMBL:ENSG00000163171 CDC42EP3 [ReferenceDNASequence:11033010] KEGG Gene (Homo sapiens):10602 CDC42EP3 [ReferenceDNASequence:11282712] NCBI Gene:10602 CDC42EP3 [ReferenceDNASequence:11282713] BioGPS Gene:10602 CDC42EP3 [ReferenceDNASequence:11282714] CTD Gene:10602 CDC42EP3 [ReferenceDNASequence:11282715] dbSNP Gene:10602 CDC42EP3 [ReferenceDNASequence:11282716] Monarch:10602 CDC42EP3 [ReferenceDNASequence:11355999] ENSEMBL_homo_sapiens_GENE:ENSG00000163171.8 CDC42EP3 [ReferenceDNASequence:11518740] UCSC:Q9UKI2 CDC42EP3 [ReferenceDNASequence:11803027] OMIM:606133 CDC42EP3 [ReferenceDNASequence:11874220] HGNC:16943 CDC42EP3 [ReferenceDNASequence:12193704] COSMIC (genes):CDC42EP3 CDC42EP3
referenceTranscript	[ReferenceRNASequence:11471883] RefSeq:NM_001270436.1 CDC42EP3 [ReferenceRNASequence:11471885] RefSeq:NM_001270437.1 CDC42EP3 [ReferenceRNASequence:11471887] RefSeq:NM_001270438.1 CDC42EP3 [ReferenceRNASequence:11471889] RefSeq:NM_006449.4 CDC42EP3 [ReferenceRNASequence:11471891] RefSeq:XM_011532482.2 CDC42EP3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BORG2_HUMAN B2R8S0 O95353 Q9UQJ0
sequenceLength	254
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q9UKI2

Referrals

(interactor)	[UndirectedInteraction:12299637] UniProt:Q5S007 <-> UniProt:Q9UKI2 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5692659] p-CDC42EP3 [cytosol] [EntityWithAccessionedSequence:R-HSA-5692689] CDC42EP3 [cytosol]
(referenceSequence)	[ModifiedResidue:5692658] phosphorylated residue at unknown position

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