UniProt:Q8N9N5 BANP

chain
  • chain:1-519
checksum 521C53F367A3A29E
comment
  • FUNCTION Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity).SUBUNIT Interacts with TP53 (By similarity). Interacts with CUX1/CDP (By similarity). Interacts with HDAC1 (PubMed:16166625). Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2 (PubMed:16166625).TISSUE SPECIFICITY Down-regulated in breast cancer cell lines.SIMILARITY Belongs to the BANP/SMAR1 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 219883
description
  • recommendedName: Protein BANP alternativeName: BEN domain-containing protein 1 alternativeName: Btg3-associated nuclear protein alternativeName: Scaffold/matrix-associated region-1-binding protein
displayName UniProt:Q8N9N5 BANP
geneName
  • BANP
  • BEND1
  • SMAR1
identifier Q8N9N5
isSequenceChanged false
keyword
  • Acetylation
  • Alternative splicing
  • Cell cycle
  • Chromatin regulator
  • Coiled coil
  • Developmental protein
  • DNA-binding
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Tumor suppressor
  • Ubl conjugation
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • BANP
otherIdentifier
  • 0005690520
  • 11739908_a_at
  • 11740935_s_at
  • 11747303_x_at
  • 11749222_s_at
  • 11753909_x_at
  • 219966_x_at
  • 228928_x_at
  • 233186_s_at
  • 3651704
  • 3651708
  • 3651714
  • 3655240
  • 3655270
  • 3655275
  • 3655278
  • 3655279
  • 3673094
  • 3673099
  • 3673100
  • 3673101
  • 3673104
  • 3673105
  • 3673117
  • 3673120
  • 3673131
  • 3673138
  • 3673140
  • 3673144
  • 3673148
  • 3673156
  • 3673167
  • 3673175
  • 3673176
  • 3673177
  • 3673178
  • 50761_at
  • 54971
  • 73242_at
  • 7997755
  • A_14_P121000
  • A_23_P22263
  • A_23_P251765
  • A_23_P251767
  • A_33_P3236272
  • GE56815
  • GO:0003674
  • GO:0003677
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005634
  • GO:0005654
  • GO:0006325
  • GO:0007049
  • GO:0007165
  • GO:0007275
  • GO:0008150
  • GO:0009056
  • GO:0016604
  • GO:0034504
  • GO:0042177
  • GO:0042802
  • GO:0043226
  • GO:0048856
  • GO:0051276
  • GO:1901796
  • HMNXSV003018649
  • Hs.194637.2.S1_3p_a_at
  • ILMN_1663631
  • ILMN_1680685
  • ILMN_1701216
  • ILMN_2396338
  • PH_hs_0026221
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BANP_HUMAN
  • A8MU25
  • A8MX25
  • B2RCF7
  • B4DNJ9
  • F5GZM0
  • Q96GJ7
  • Q9NWY1
sequenceLength 519
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q8N9N5

Referrals

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