created | [InstanceEdit:211543] Garapati, P V, 2008-02-05 13:51:16 |
dbId | 211545 |
displayName | The Tie2/Tek receptor tyrosine kinase plays a pivotal role i... |
modified | [InstanceEdit:1458608] D'Eustachio, P, 2011-07-21 |
schemaClass | Summation |
text |
The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation. These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation. |
(summation) |
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