The Tie2/Tek receptor tyrosine kinase plays a pivotal role i...

created [InstanceEdit:211543] Garapati, P V, 2008-02-05 13:51:16
dbId 211545
displayName The Tie2/Tek receptor tyrosine kinase plays a pivotal role i...
modified [InstanceEdit:1458608] D'Eustachio, P, 2011-07-21
schemaClass Summation
text The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.
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