Activating point mutations in FGFR3 are found in the extrace...

created [InstanceEdit:2064284] Rothfels, K, 2012-01-18
dbId 2064285
displayName Activating point mutations in FGFR3 are found in the extrace...
modified [InstanceEdit:2085545] Rothfels, K, 2012-02-03
schemaClass Summation
text Activating point mutations in FGFR3 are found in the extracellular ligand-binding domain, the transmembrane region and the tyrosine kinase domain and are believed to result in ligand-independent activation of the receptor (Webster and Donoghue, 1996; Wenbster, 1997). These mutations, although initially characterized in the context of autosomal skeletal disorders, are now being identified in a range of cancers including bladder, cervical, breast, prostate, head and neck, and multiple myeloma (reviewed in Wesche, 2011).
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