Unlike FGFR2 and FGFR3, FGFR1 appears not to be a frequent t...

created [InstanceEdit:2054060] Rothfels, K, 2012-01-12
dbId 2054061
displayName Unlike FGFR2 and FGFR3, FGFR1 appears not to be a frequent t...
modified [InstanceEdit:5691486] Rothfels, Karen, 2015-05-07
schemaClass Summation
text Unlike FGFR2 and FGFR3, FGFR1 appears not to be a frequent target of activating point mutations (reviewed in Wesche, 2011; Turner and Grose, 2010). Germline point mutations at residue P252 have been identified in Pfeiffer syndrome (reviewed in Webster and Donoghue, 1997; Burke, 1998; Cunningham, 2007) while mutation of the same residue arising somatically has been identified in melanoma and lung cancer (Ruhe, 2007; Davies, 2005). Two kinase domain mutations have been characterized in glioblastoma (Rand, 2005; Network TCGA, 2008), both at positions that are also mutated in an autosomal disorder in one of the FGFR family members (Muenke, 1994; Bellus, 1995a; Bellus, 2000; Tavormina, 1995a; Tavormina, 1999).
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