Reactome | UniProt:Q9Y3E7 CHMP3

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UniProt:Q9Y3E7 CHMP3 Show undefined attributes

chain	initiator methionine: chain:2-222
checksum	7B1ACE5EA453E8C0
comment	FUNCTION Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.SUBUNIT Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Forms a metastable monomer in solution; its core structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes into a flat lattice via two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. May interact with IGFBP7; the relevance of such interaction however remains unclear. Interacts with CHMP2A. Interacts with CHMP4A; the interaction requires the release of CHMP4A autoinhibition. Interacts with VPS4A. Interacts with STAMBP; the interaction appears to relieve the autoinhibition of CHMP3. Interacts with VTA1.INTERACTION Localizes to the midbody of dividing cells.ALTERNATIVE PRODUCTS Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.DOMAIN The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.MISCELLANEOUS Its overexpression strongly inhibits HIV-1 release.SIMILARITY Belongs to the SNF7 family.
created	[InstanceEdit:184440] D'Eustachio, P, 2006-07-27 16:05:42
crossReference	[DatabaseIdentifier:10980455] Pharos - Targets:Q9Y3E7 [DatabaseIdentifier:11076309] OpenTargets:ENSG00000115561 [DatabaseIdentifier:11613749] RefSeq:NP_001005753.1 [DatabaseIdentifier:11613758] RefSeq:NP_001180446.1 [DatabaseIdentifier:11613760] RefSeq:NP_001185883.1 [DatabaseIdentifier:11613770] RefSeq:NP_057163.1 [DatabaseIdentifier:11759408] PDB:2GD5 [DatabaseIdentifier:11759414] PDB:2XZE [DatabaseIdentifier:11759421] PDB:3FRT [DatabaseIdentifier:11759427] PDB:3FRV [DatabaseIdentifier:11759431] PDB:7ZCG [DatabaseIdentifier:11759438] PDB:7ZCH [DatabaseIdentifier:11837690] PRO:Q9Y3E7 [DatabaseIdentifier:11851684] GeneCards:Q9Y3E7 [DatabaseIdentifier:11903337] HPA:ENSG00000115561-CHMP3 [DatabaseIdentifier:12166961] Ensembl:ENSG00000115561 [DatabaseIdentifier:12166962] Ensembl:ENSP00000387045 [DatabaseIdentifier:12166963] Ensembl:ENST00000409727 [DatabaseIdentifier:12166964] Ensembl:ENST00000409225 [DatabaseIdentifier:12166965] Ensembl:ENSP00000263856 [DatabaseIdentifier:12166966] Ensembl:ENST00000263856 [DatabaseIdentifier:12166967] Ensembl:ENSP00000386590
databaseName	UniProt
dbId	184494
description	recommendedName: Charged multivesicular body protein 3 alternativeName: Chromatin-modifying protein 3 alternativeName: Neuroendocrine differentiation factor alternativeName: Vacuolar protein sorting-associated protein 24 shortName: hVps24
displayName	UniProt:Q9Y3E7 CHMP3
geneName	CHMP3 CGI149 NEDF VPS24 CGI-149
identifier	Q9Y3E7
isSequenceChanged	false
keyword	3D-structure Alternative splicing Apoptosis Cell cycle Cell division Coiled coil Cytoplasm Endosome Isopeptide bond Lipoprotein Membrane Myristate Phosphoprotein Protein transport Reference proteome Transport Ubl conjugation
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	CHMP3
otherIdentifier	11717424_x_at 11717425_a_at 11717426_a_at 217837_PM_s_at 217837_s_at 222436_PM_s_at 222436_s_at 222437_PM_s_at 222437_s_at 2562820 2562822 2562823 2562824 2562825 2562826 2562829 2562831 2562832 2562840 2562841 2562851 2562858 2562859 3652462 49383_at 51652 8053562 A_23_P79510 A_24_P240065 A_33_P3316639 GE88124 GO:0000278 GO:0000421 GO:0000776 GO:0000815 GO:0000910 GO:0001778 GO:0005515 GO:0005546 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005643 GO:0005694 GO:0005737 GO:0005764 GO:0005765 GO:0005768 GO:0005769 GO:0005770 GO:0005771 GO:0005773 GO:0005828 GO:0005829 GO:0005856 GO:0005886 GO:0006914 GO:0006915 GO:0006997 GO:0007010 GO:0007034 GO:0007040 GO:0007049 GO:0007059 GO:0007080 GO:0008289 GO:0008333 GO:0010824 GO:0012501 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0019076 GO:0030163 GO:0030496 GO:0031210 GO:0031410 GO:0031468 GO:0031902 GO:0032467 GO:0032509 GO:0032585 GO:0036258 GO:0039702 GO:0042060 GO:0042802 GO:0043162 GO:0043226 GO:0044790 GO:0045324 GO:0046761 GO:0051036 GO:0051258 GO:0051301 GO:0051469 GO:0061024 GO:0061763 GO:0061952 GO:0065003 GO:0070062 GO:0071985 GO:0090148 GO:0097352 GO:0098542 GO:0098772 GO:0140014 GO:0140678 GO:1901673 GO:1902774 GO:1904930 GO:1990381 GO:2000641 HMNXSV003034238 Hs.189658.0.S1_3p_a_at ILMN_1683827 ILMN_1743505 ILMN_2406043 PH_hs_0026770 PH_hs_0039950 TC02004385.hg TC02005035.hg g13325201_3p_a_at g7706352_3p_a_at g7706352_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-917722] CHMP3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9631191] CHMP3 [endosome membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8994711] ENSEMBL:ENSG00000115561 CHMP3 [ReferenceDNASequence:11025273] KEGG Gene (Homo sapiens):100526767 CHMP3 [ReferenceDNASequence:11025274] KEGG Gene (Homo sapiens):51652 CHMP3 [ReferenceDNASequence:11258851] NCBI Gene:100526767 CHMP3 [ReferenceDNASequence:11258852] BioGPS Gene:100526767 CHMP3 [ReferenceDNASequence:11258853] CTD Gene:100526767 CHMP3 [ReferenceDNASequence:11258854] dbSNP Gene:100526767 CHMP3 [ReferenceDNASequence:11258855] Monarch:100526767 CHMP3 [ReferenceDNASequence:11258861] NCBI Gene:51652 CHMP3 [ReferenceDNASequence:11258862] BioGPS Gene:51652 CHMP3 [ReferenceDNASequence:11258863] CTD Gene:51652 CHMP3 [ReferenceDNASequence:11258864] dbSNP Gene:51652 CHMP3 [ReferenceDNASequence:11258865] Monarch:51652 CHMP3 [ReferenceDNASequence:11350626] ENSEMBL_homo_sapiens_GENE:ENSG00000115561.16 CHMP3 [ReferenceDNASequence:11514892] UCSC:Q9Y3E7 CHMP3 [ReferenceDNASequence:11796466] OMIM:610052 CHMP3 [ReferenceDNASequence:11879030] HGNC:29865 CHMP3 [ReferenceDNASequence:12198766] COSMIC (genes):CHMP3 CHMP3
referenceTranscript	[ReferenceRNASequence:11457356] RefSeq:NM_001005753.2 CHMP3 [ReferenceRNASequence:11457362] RefSeq:NM_001193517.1 CHMP3 [ReferenceRNASequence:11457368] RefSeq:NM_001198954.1 CHMP3 [ReferenceRNASequence:11457374] RefSeq:NM_016079.3 CHMP3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CHMP3_HUMAN A8K3W0 B4DG34 B8ZZM0 B8ZZX5 Q3ZTS9 Q53S71 Q53SU5 Q9NZ51
sequenceLength	222
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q9Y3E7

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-917722] CHMP3 [cytosol] [EntityWithAccessionedSequence:R-HSA-9631191] CHMP3 [endosome membrane]
(interactor)	[UndirectedInteraction:12209675] UniProt:Q9Y3E7 <-> UniProt:Q9UQN3 (IntAct) [UndirectedInteraction:12209673] UniProt:Q9Y3E7 <-> UniProt:Q9H444 (IntAct) [UndirectedInteraction:12209671] UniProt:Q9Y3E7 <-> UniProt:O95630 (IntAct) [UndirectedInteraction:12203099] UniProt:O43633 <-> UniProt:Q9Y3E7 (IntAct)

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