Reactome | UniProt:P03508 NS

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UniProt:P03508 NS Show undefined attributes

chain	chain:1-121
checksum	ABFAC522B4F14854
comment	FUNCTION Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.SUBUNIT Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.INTERACTION Average number present in a viral particle is estimated to be 130-200 molecules.SIMILARITY Belongs to the influenza viruses NEP family.
created	[InstanceEdit:169110] Gillespie, ME, 2005-11-22 21:39:50
crossReference	[DatabaseIdentifier:11634735] RefSeq:NP_040983.1 [DatabaseIdentifier:11792814] PDB:1PD3 [DatabaseIdentifier:11835607] PRO:P03508
databaseName	UniProt
dbId	169126
description	recommendedName: fullName evidence="1"Nuclear export protein shortName evidence="1"NEP alternativeName: fullName evidence="1"Non-structural protein 2 shortName evidence="1"NS2
displayName	UniProt:P03508 NS
geneName	NS
identifier	P03508
isSequenceChanged	false
keyword	3D-structure Alternative splicing Host nucleus Host-virus interaction Reference proteome Transport Virion
modified	[InstanceEdit:11804066] Wright, Adam, 2024-03-11
name	NS
physicalEntity	[EntityWithAccessionedSequence:R-FLU-169705] NEP/NS2 [extracellular region] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-189148] NEP/NS2 [endocytic vesicle membrane] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-189176] NEP/NS2 [endosome lumen] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-192845] NEP/NS2 [cytosol] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-169474] NEP/NS2 [nucleoplasm] - Influenza A virus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11037871] KEGG Gene (Hepatitis C Virus):956532 NS [ReferenceDNASequence:11296535] NCBI Gene:956532 NS [ReferenceDNASequence:11296536] BioGPS Gene:956532 NS [ReferenceDNASequence:11296537] Monarch:956532 NS
referenceTranscript	[ReferenceRNASequence:11480269] RefSeq:NC_002020.1 NS
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NEP_I34A1 A4GXG8 Q20N33 Q67266 Q71QT4
sequenceLength	121
species	[Species:9031716] Influenza A virus
url	https://purl.uniprot.org/uniprot/P03508

Referrals

(interactor)	[UndirectedInteraction:12279713] UniProt:P03508 <-> UniProt:Q96RP9 (IntAct) [UndirectedInteraction:12279711] UniProt:P03508 <-> UniProt:Q13155 (IntAct) [UndirectedInteraction:12263689] UniProt:P03485 <-> UniProt:P03508 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-FLU-169705] NEP/NS2 [extracellular region] [EntityWithAccessionedSequence:R-FLU-189148] NEP/NS2 [endocytic vesicle membrane] [EntityWithAccessionedSequence:R-FLU-189176] NEP/NS2 [endosome lumen] [EntityWithAccessionedSequence:R-FLU-192845] NEP/NS2 [cytosol] [EntityWithAccessionedSequence:R-FLU-169474] NEP/NS2 [nucleoplasm]