Reactome | UniProt:P03433 PA

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UniProt:P03433 PA Show undefined attributes

chain	chain:1-716
checksum	8829F53525814394
comment	FUNCTION Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.COFACTOR Binds 2 manganese ions per subunit.SUBUNIT Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via C-terminus) with PB1 (via N-terminus).INTERACTION PB1 and PA are transported in the host nucleus as a complex.ALTERNATIVE PRODUCTS Phosphorylated on serines and threonines by host kinases, including human casein kinase II.SIMILARITY Belongs to the influenza viruses PA family.
created	[InstanceEdit:169110] Gillespie, ME, 2005-11-22 21:39:50
crossReference	[DatabaseIdentifier:11634738] RefSeq:NP_040986.1 [DatabaseIdentifier:11792848] PDB:2ZNL [DatabaseIdentifier:11792852] PDB:4YYL [DatabaseIdentifier:11792854] PDB:4ZHZ [DatabaseIdentifier:11792855] PDB:4ZI0 [DatabaseIdentifier:11792858] PDB:4ZQQ [DatabaseIdentifier:11792860] PDB:5FDD [DatabaseIdentifier:11792862] PDB:5FDG [DatabaseIdentifier:11792864] PDB:5I13 [DatabaseIdentifier:11792866] PDB:5JHT [DatabaseIdentifier:11792868] PDB:5JHV [DatabaseIdentifier:11792870] PDB:7XGC [DatabaseIdentifier:11814644] PRO:P03433 [DatabaseIdentifier:11853210] ZINC - Substances:PA_I34A1 [DatabaseIdentifier:11859656] ZINC - Investigational:PA_I34A1 [DatabaseIdentifier:11861032] ZINC - Predictions - Purchasable:PA_I34A1 [DatabaseIdentifier:11864262] ZINC target:P03433
databaseName	UniProt
dbId	169114
description	recommendedName: fullName evidence="1"Polymerase acidic protein ecNumber evidence="1"3.1.-.- alternativeName: fullName evidence="1"RNA-directed RNA polymerase subunit P2
displayName	UniProt:P03433 PA
geneName	PA
identifier	P03433
isSequenceChanged	false
keyword	3D-structure Cap snatching Endonuclease Eukaryotic host gene expression shutoff by virus Eukaryotic host transcription shutoff by virus Host cytoplasm Host gene expression shutoff by virus Host nucleus Host-virus interaction Hydrolase Inhibition of host RNA polymerase II by virus Manganese Metal-binding Nuclease Phosphoprotein Reference proteome Ribosomal frameshifting
modified	[InstanceEdit:11863377] Wright, Adam, 2024-03-11
name	PA
physicalEntity	[EntityWithAccessionedSequence:R-FLU-169243] PA [extracellular region] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-189131] PA [endosome lumen] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-195948] PA [cytosol] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-188877] PA [nucleoplasm] - Influenza A virus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11296550] NCBI Gene:956535 PA [ReferenceDNASequence:11296551] BioGPS Gene:956535 PA [ReferenceDNASequence:11296552] Monarch:956535 PA
referenceTranscript	[ReferenceRNASequence:11480275] RefSeq:NC_002022.1 PA
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PA_I34A1 A4GXH3 Q20N31 Q8JUU6
sequenceLength	716
species	[Species:9031716] Influenza A virus
url	https://purl.uniprot.org/uniprot/P03433

Referrals

(interactor)	[UndirectedInteraction:12253863] UniProt:P03433 <-> UniProt:P03428 (IntAct) [UndirectedInteraction:12253861] UniProt:P03433 <-> UniProt:P03485 (IntAct) [UndirectedInteraction:12253859] UniProt:P03433 <-> UniProt:P03431 (IntAct) [UndirectedInteraction:12234173] UniProt:P49736 <-> UniProt:P03433 (IntAct) [UndirectedInteraction:12200659] UniProt:P03466 <-> UniProt:P03433 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-FLU-169243] PA [extracellular region] [EntityWithAccessionedSequence:R-FLU-189131] PA [endosome lumen] [EntityWithAccessionedSequence:R-FLU-195948] PA [cytosol] [EntityWithAccessionedSequence:R-FLU-188877] PA [nucleoplasm]