Reactome | UniProt:P03428 PB2

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UniProt:P03428 PB2 Show undefined attributes

chain	chain:1-759
checksum	10D2D1608AE536D2
comment	FUNCTION Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.SUBUNIT Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus) (PubMed:28169297). Interacts with nucleoprotein NP (via N-terminus) (PubMed:25043584, PubMed:22570712). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response (PubMed:23246644, PubMed:20538852).INTERACTION Belongs to the influenza viruses PB2 family.
created	[InstanceEdit:169110] Gillespie, ME, 2005-11-22 21:39:50
crossReference	[DatabaseIdentifier:11634733] RefSeq:NP_040987.1 [DatabaseIdentifier:11792816] PDB:2ZTT [DatabaseIdentifier:11792820] PDB:3A1G [DatabaseIdentifier:11792821] PDB:3CW4 [DatabaseIdentifier:11792823] PDB:3WI0 [DatabaseIdentifier:11792827] PDB:3WI1 [DatabaseIdentifier:11792831] PDB:4ENF [DatabaseIdentifier:11792835] PDB:4J2R [DatabaseIdentifier:11792840] PDB:4U6O [DatabaseIdentifier:11792843] PDB:7JYW [DatabaseIdentifier:11792850] PDB:7JYX [DatabaseIdentifier:11828263] PRO:P03428 [DatabaseIdentifier:11854421] ZINC - Substances:PB2_I34A1 [DatabaseIdentifier:11862989] ZINC - Predictions - Purchasable:PB2_I34A1 [DatabaseIdentifier:11866191] ZINC target:P03428
databaseName	UniProt
dbId	169094
description	recommendedName: fullName evidence="2"Polymerase basic protein 2 alternativeName: fullName evidence="2"RNA-directed RNA polymerase subunit P3
displayName	UniProt:P03428 PB2
geneName	PB2
identifier	P03428
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cap snatching Eukaryotic host gene expression shutoff by virus Eukaryotic host transcription shutoff by virus Host gene expression shutoff by virus Host mitochondrion Host nucleus Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host MAVS by virus Inhibition of host RLR pathway by virus Inhibition of host RNA polymerase II by virus mRNA capping mRNA processing Reference proteome Viral immunoevasion Viral transcription Virion
modified	[InstanceEdit:11863377] Wright, Adam, 2024-03-11
name	PB2
physicalEntity	[EntityWithAccessionedSequence:R-FLU-169238] PB2 [extracellular region] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-189140] PB2 [endosome lumen] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-188851] PB2 [cytosol] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-195946] PB2 [cytosol] - Influenza A virus [EntityWithAccessionedSequence:R-FLU-188857] PB2 [nucleoplasm] - Influenza A virus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11037872] KEGG Gene (Hepatitis C Virus):956536 PB2 [ReferenceDNASequence:11296538] NCBI Gene:956536 PB2 [ReferenceDNASequence:11296539] BioGPS Gene:956536 PB2 [ReferenceDNASequence:11296540] Monarch:956536 PB2
referenceTranscript	[ReferenceRNASequence:11480268] RefSeq:NC_002023.1 PB2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PB2_I34A1 A4GXH0 Q20N28 Q8JUU8
sequenceLength	759
species	[Species:9031716] Influenza A virus
url	https://purl.uniprot.org/uniprot/P03428

Referrals

(interactor)	[UndirectedInteraction:12320083] UniProt:P03428 <-> UniProt:Q12800 (IntAct) [UndirectedInteraction:12302973] UniProt:P03431 <-> UniProt:P03428 (IntAct) [UndirectedInteraction:12253863] UniProt:P03433 <-> UniProt:P03428 (IntAct) [UndirectedInteraction:12200657] UniProt:P03466 <-> UniProt:P03428 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-FLU-169238] PB2 [extracellular region] [EntityWithAccessionedSequence:R-FLU-189140] PB2 [endosome lumen] [EntityWithAccessionedSequence:R-FLU-188851] PB2 [cytosol] [EntityWithAccessionedSequence:R-FLU-195946] PB2 [cytosol] [EntityWithAccessionedSequence:R-FLU-188857] PB2 [nucleoplasm]