UniProt:P04585 gag-pol

chain
  • initiator methionine:1
  • chain:2-1435
  • chain:2-132
  • chain:133-363
  • peptide:364-377
  • chain:378-432
  • peptide:433-440
  • chain:441-488
  • chain:489-587
  • chain:588-1147
  • chain:588-1027
  • chain:1028-1147
  • chain:1148-1435
checksum 8487B36BDEAC5FE4
comment
  • ACTIVITY REGULATION Protease: The viral protease is inhibited by many synthetic protease inhibitors (PIs), such as amprenavir, atazanavir, indinavir, loprinavir, nelfinavir, ritonavir and saquinavir. Use of protease inhibitors in tritherapy regimens permit more ambitious therapeutic strategies. Reverse transcriptase/ribonuclease H: RT can be inhibited either by nucleoside RT inhibitors (NRTIs) or by non nucleoside RT inhibitors (NNRTIs). NRTIs act as chain terminators, whereas NNRTIs inhibit DNA polymerization by binding a small hydrophobic pocket near the RT active site and inducing an allosteric change in this region. Classical NRTIs are abacavir, adefovir (PMEA), didanosine (ddI), lamivudine (3TC), stavudine (d4T), tenofovir (PMPA), zalcitabine (ddC), and zidovudine (AZT). Classical NNRTIs are atevirdine (BHAP U-87201E), delavirdine, efavirenz (DMP-266), emivirine (I-EBU), and nevirapine (BI-RG-587). The tritherapies used as a basic effective treatment of AIDS associate two NRTIs and one NNRTI.MISCELLANEOUS HIV-1 lineages are divided in three main groups, M (for Major), O (for Outlier), and N (for New, or Non-M, Non-O). The vast majority of strains found worldwide belong to the group M. Group O seems to be endemic to and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. The group N is represented by a limited number of isolates from Cameroonian persons. The group M is further subdivided in 9 clades or subtypes (A to D, F to H, J and K).MISCELLANEOUS Resistance to inhibitors associated with mutations are observed both in viral protease and in reverse transcriptase. Most of the time, single mutations confer only a modest reduction in drug susceptibility. Combination of several mutations is usually required to develop a high-level drug resistance. These mutations are predominantly found in clade B viruses and not in other genotypes. They are listed in this entry which is a representative of clade B.
created [InstanceEdit:165206] Schmidt, EE, 2005-08-03 04:18:22
crossReference
databaseName UniProt
dbId 165325
description
  • recommendedName: Gag-Pol polyprotein alternativeName: Pr160Gag-Pol component recommendedName: Matrix protein p17 shortName:MA /component component recommendedName: Capsid protein p24 shortName:CA /component component recommendedName: fullName evidence="34"Spacer peptide 1 shortName:SP1 alternativeName: p2 /component component recommendedName: Nucleocapsid protein p7 shortName:NC /component component recommendedName: Transframe peptide shortName:TF /component component recommendedName: p6-pol shortName:p6* /component component recommendedName: Protease ecNumber3.4.23.16/ecNumber alternativeName: PR alternativeName: Retropepsin /component component recommendedName: Reverse transcriptase/ribonuclease H ecNumber evidence="31"2.7.7.49/ecNumber ecNumber evidence="31"2.7.7.7/ecNumber ecNumber evidence="31"3.1.26.13/ecNumber alternativeName: Exoribonuclease H ecNumber3.1.13.2/ecNumber alternativeName: p66 RT /component component recommendedName: p51 RT /component component recommendedName: p15 /component component recommendedName: Integrase shortName:IN ecNumber evidence="83"2.7.7.-/ecNumber ecNumber evidence="83"3.1.-.-/ecNumber /component
displayName UniProt:P04585 gag-pol
geneName
  • gag-pol
identifier P04585
isSequenceChanged false
keyword
  • 3D-structure
  • Activation of host caspases by virus
  • AIDS
  • Aspartyl protease
  • Capsid protein
  • DNA integration
  • DNA recombination
  • DNA-binding
  • DNA-directed DNA polymerase
  • Endonuclease
  • Eukaryotic host gene expression shutoff by virus
  • Eukaryotic host translation shutoff by virus
  • Host cell membrane
  • Host cytoplasm
  • Host endosome
  • Host gene expression shutoff by virus
  • Host membrane
  • Host nucleus
  • Host-virus interaction
  • Hydrolase
  • Lipid-binding
  • Lipoprotein
  • Magnesium
  • Membrane
  • Metal-binding
  • Modulation of host cell apoptosis by virus
  • Multifunctional enzyme
  • Myristate
  • Nuclease
  • Nucleotidyltransferase
  • Phosphoprotein
  • Protease
  • Reference proteome
  • Repeat
  • Ribosomal frameshifting
  • RNA-binding
  • RNA-directed DNA polymerase
  • Transferase
  • Viral genome integration
  • Viral nucleoprotein
  • Viral penetration into host nucleus
  • Viral release from host cell
  • Virion
  • Virion maturation
  • Virus entry into host cell
  • Zinc
  • Zinc-finger
modified [InstanceEdit:11532522] Shorser, Solomon, 2020-11-23
name
  • gag-pol
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • POL_HV1H2
  • O09777
  • Q9WJC5
sequenceLength 1435
species [Species:164493] Human immunodeficiency virus 1
url http://purl.uniprot.org/uniprot/P04585

Referrals

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