UniProt:Q62862-2 Map2k5

chain
  • chain:1-448
checksum 1B1CC8B05789B90D
comment
  • FUNCTION Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity).CATALYTIC ACTIVITY ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]CATALYTIC ACTIVITY ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]CATALYTIC ACTIVITY ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]COFACTOR Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity).SUBCELLULAR LOCATION The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.SUBCELLULAR LOCATION The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.ALTERNATIVE PRODUCTS MEK5 beta is ubiquitously distributed with highest levels in the liver, whereas MEK5 alpha is expressed only in liver and brain.DOMAIN Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity).PTM Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
crossReference
databaseName UniProt
dbId 150500
description
  • recommendedName: Dual specificity mitogen-activated protein kinase kinase 5 shortName: MAP kinase kinase 5 shortName: MAPKK 5 ecNumber: 2.7.12.2 alternativeName: MAPK/ERK kinase 5 shortName: MEK 5
displayName UniProt:Q62862-2 Map2k5
geneName
  • Map2k5
  • Mek5
  • Mkk5
  • Prkmk5
identifier Q62862
isSequenceChanged false
isoformParent
keyword
  • Alternative splicing
  • ATP-binding
  • Cytoplasm
  • Kinase
  • Magnesium
  • Membrane
  • Metal-binding
  • Nucleotide-binding
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transferase
  • Tyrosine-protein kinase
modified [InstanceEdit:11936968] Wright, Adam, 2024-03-11
name
  • Map2k5
otherIdentifier
  • 10918118
  • 1386959_a_at
  • 17853338
  • 29568
  • 5660199
  • 5734165
  • 5777351
  • 5799791
  • 5828834
  • 5868117
  • 5927396
  • 5967753
  • 5968014
  • 5982172
  • 6050187
  • 6057029
  • 6096390
  • 6116469
  • 6121529
  • 6178775
  • 6195289
  • 6293379
  • 6438457
  • 6439965
  • 6510292
  • 6542059
  • 6588471
  • 6656624
  • 6676527
  • 6730123
  • A_42_P485589
  • GE20446
  • GE21966
  • GO:0000165
  • GO:0003824
  • GO:0004672
  • GO:0004708
  • GO:0005515
  • GO:0005524
  • GO:0005819
  • GO:0005856
  • GO:0006468
  • GO:0007507
  • GO:0016740
  • GO:0023052
  • GO:0036211
  • GO:0043226
  • GO:0048009
  • GO:0048856
  • GO:0140096
  • ILMN_1376514
  • PH_rn_0011632
  • U37462_s_at
  • U37464_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • MP2K5_RAT
  • Q62863
  • Q62864
sequenceLength 448
species [Species:48895] Rattus norvegicus
url https://purl.uniprot.org/uniprot/Q62862-2
variantIdentifier Q62862-2
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