Erlotinib (OSI-774, Tarceva) is an EGFR-specific tyrosine ki...

created [InstanceEdit:1181196] Orlic-Milacic, Marija, 2011-01-28
dbId 1181195
displayName Erlotinib (OSI-774, Tarceva) is an EGFR-specific tyrosine ki...
literatureReference
schemaClass Summation
text Erlotinib (OSI-774, Tarceva) is an EGFR-specific tyrosine kinase inhibitor (TKI) from the anilinoquinazoline class of TKIs, developed by OSI/Genentech. Erlotinib competitively inhibits binding of ATP to kinase domain of EGFR, thereby preventing EGFR autophosphorylation and downstream signaling, which halts proliferation of EGFR-dependent tumor cells (Moyer et al. 1997 , Stamos et al. 2002).
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