Reactome | POLK incorporates dNMP opposite to damaged DNA base

Schema > Reaction > Entries

POLK incorporates dNMP opposite to damaged DNA base Show undefined attributes

catalystActivity	[CatalystActivity:10711007] DNA-directed DNA polymerase activity of POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10711009
displayName	POLK incorporates dNMP opposite to damaged DNA base
eventOf	[Pathway:R-DME-5655862] Translesion synthesis by POLK - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-DME-5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
isInDisease	false
isInferred	true
name	POLK incorporates dNMP opposite to damaged DNA base
output	[Complex:R-DME-5655912] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5655892
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5655862] Translesion synthesis by POLK
(precedingEvent)	[Reaction:R-DME-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini
(inferredTo)	[Reaction:R-HSA-5655892] POLK incorporates dNMP opposite to damaged DNA base