Reactome | Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10710889] ubiquitin protein ligase activity of Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DME-5654362] Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-5654679] CBL ubiquitinates FRS2 and FGFR3 - Drosophila melanogaster
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10710886
displayName	Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
hasComponent	[Complex:R-DME-5654198] Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] [Complex:R-DME-182964] p-Y371-CBL:GRB2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5654307] Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] - Homo sapiens
name	Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2
producedByEvent	[Reaction:R-DME-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5654307
summation	[Summation:9864367] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-5654679] CBL ubiquitinates FRS2 and FGFR3
(physicalEntity)	[CatalystActivity:10710889] ubiquitin protein ligase activity of Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
(hasComponent)	[Complex:R-DME-5654362] Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
(output)	[Reaction:R-DME-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3
(inferredTo)	[Complex:R-HSA-5654307] Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]