Reactome | Activated FGFR3 phosphorylates PPTN11

Schema > Reaction > Entries

Activated FGFR3 phosphorylates PPTN11 Show undefined attributes

catalystActivity	[CatalystActivity:10710817] protein tyrosine kinase activity of Activated FGFR3:p-FRS:PTPN11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10710819
displayName	Activated FGFR3 phosphorylates PPTN11
eventOf	[Pathway:R-DME-5654706] FRS-mediated FGFR3 signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-DME-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 - Drosophila melanogaster [Reaction:R-DME-5654641] Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5654631] Activated FGFR3 phosphorylates PPTN11 - Homo sapiens
input	[Complex:R-DME-5654310] Activated FGFR3:p-FRS:PTPN11 [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
name	Activated FGFR3 phosphorylates PPTN11
output	[Complex:R-DME-5654312] Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5654631
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5654706] FRS-mediated FGFR3 signaling
(precedingEvent)	[Reaction:R-DME-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-DME-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 [Reaction:R-DME-5654641] Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
(inferredTo)	[Reaction:R-HSA-5654631] Activated FGFR3 phosphorylates PPTN11