Reactome | Activated FGFR4:p-SHC1 binds GRB2:SOS1

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Activated FGFR4:p-SHC1 binds GRB2:SOS1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10710674
displayName	Activated FGFR4:p-SHC1 binds GRB2:SOS1
eventOf	[Pathway:R-DME-5654719] SHC-mediated cascade:FGFR4 - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Homo sapiens
input	[Complex:R-DME-5654340] Activated FGFR4:pY-SHC1 [plasma membrane] [Complex:R-DME-109797] GRB2-1:SOS1 [cytosol]
isInDisease	false
isInferred	true
name	Activated FGFR4:p-SHC1 binds GRB2:SOS1
output	[Complex:R-DME-5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-DME-5654428] Activated FGFR4 phosphorylates SHC1 - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5654423
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5654719] SHC-mediated cascade:FGFR4
(precedingEvent)	[Reaction:R-DME-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1