Reactome | Gamma-secretase cleaves YBX1:NOTCH3

Schema > BlackBoxEvent > Entries

Gamma-secretase cleaves YBX1:NOTCH3 Show undefined attributes

catalystActivity	[CatalystActivity:10551357] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10551556
displayName	Gamma-secretase cleaves YBX1:NOTCH3
eventOf	[Pathway:R-XTR-9017802] Noncanonical activation of NOTCH3 - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:937686] Notch receptor processing, ligand-dependent
inferredFrom	[BlackBoxEvent:R-HSA-9017817] Gamma-secretase cleaves YBX1:NOTCH3 - Homo sapiens
input	[Complex:R-XTR-9017807] YBX1:NOTCH3 [plasma membrane]
isInDisease	false
isInferred	true
name	Gamma-secretase cleaves YBX1:NOTCH3
output	[EntityWithAccessionedSequence:R-XTR-157647] NICD3 [cytosol]
precedingEvent	[Reaction:R-XTR-9017797] NOTCH3 binds YBX1 - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9017817
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9017802] Noncanonical activation of NOTCH3
(inferredTo)	[BlackBoxEvent:R-HSA-9017817] Gamma-secretase cleaves YBX1:NOTCH3