Reactome | SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

Schema > Reaction > Entries

SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10444324] serotonin:sodium symporter activity of SLC6A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10444326
displayName	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol
eventOf	[Pathway:R-DRE-380615] Serotonin clearance from the synaptic cleft - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172102] serotonin uptake
inferredFrom	[Reaction:R-HSA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-114523] 5HT [extracellular region] [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
name	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol SERT mediates serotonin uptake
output	[SimpleEntity:R-ALL-209914] 5HT [cytosol] [SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-444008
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-380615] Serotonin clearance from the synaptic cleft
(inferredTo)	[Reaction:R-HSA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

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