Reactome | 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol

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17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol Show undefined attributes

catalystActivity	[CatalystActivity:10436534] 3-beta-hydroxy-delta5-steroid dehydrogenase activity of HSD2B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10436538
displayName	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol
eventOf	[Pathway:R-DRE-194002] Glucocorticoid biosynthesis - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-193961] Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone - Danio rerio
inferredFrom	[Reaction:R-HSA-196372] 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol - Homo sapiens
input	[SimpleEntity:R-ALL-193124] 17aHPREG [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
name	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol 17-hydroxypregnenolone + NAD+ => pregn-5-ene-3,20-dione-17-ol + NADH + H+
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-196366] pregn-5-ene-3,20-dione-17-ol [cytosol]
precedingEvent	[Reaction:R-DRE-193068] CYP17A1 17-hydroxylates PREG - Danio rerio
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-196372
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-194002] Glucocorticoid biosynthesis
(precedingEvent)	[Reaction:R-DRE-193961] Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
(inferredTo)	[Reaction:R-HSA-196372] 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol

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